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A kind of high specific surface area calcium phosphate ceramic porous support and preparation method thereof

A technology of calcium phosphate ceramics with high specific surface area, which is applied in the fields of medical science and prostheses, which can solve the problems of irregular hole shape, low porosity of porous scaffold, and uneven pore size, so as to achieve good bonding effect and benefit Cell and blood vessel growth, practical effect

Inactive Publication Date: 2020-10-16
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a high specific surface area calcium phosphate ceramic porous support and its preparation method to solve the problems of the existing porous support with low porosity, irregular hole shape, non-uniform pore size and low cost

Method used

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  • A kind of high specific surface area calcium phosphate ceramic porous support and preparation method thereof
  • A kind of high specific surface area calcium phosphate ceramic porous support and preparation method thereof
  • A kind of high specific surface area calcium phosphate ceramic porous support and preparation method thereof

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Embodiment 1

[0024] The preparation method of the high specific surface area calcium phosphate ceramic porous support of the present embodiment comprises:

[0025] Dissolve the binder in water to obtain a binder solution with a concentration of 10wt%, mix the binder solution and β-tricalcium phosphate powder evenly in a mass ratio of 1:1, and then mix the hydrogen peroxide solution with β-phosphoric acid The mass ratio of the tricalcium powder is 0.25:1, and the hydrogen peroxide solution with a concentration of 25wt% is added and mixed evenly, and then treated with a microwave with a power of 750W for 5s, and the obtained mixed slurry is poured into a mold, and then heated at 40 It was dried at 1000°C for 18 hours and sintered at 1000°C for 5 hours to prepare a calcium phosphate ceramic porous scaffold.

[0026] The above-mentioned binder solution includes: 3wt% of gelatin, 2wt% of polyvinylpyrrolidone, 2wt% of polyvinyl alcohol and 3wt% of methylcellulose, and the balance is distilled wa...

Embodiment 2

[0028] The preparation method of the high specific surface area calcium phosphate ceramic porous support of the present embodiment comprises:

[0029] Dissolve the binder in water to obtain a binder solution with a concentration of 20wt%, mix the binder solution and β-tricalcium phosphate powder evenly in a mass ratio of 4:1, and then mix the hydrogen peroxide solution with β-phosphoric acid The mass ratio of tricalcium powder is 0.2:1, adding hydrogen peroxide solution with a concentration of 30wt% and mixing evenly, then using a microwave with a power of 650W for 25s, pouring the obtained mixed slurry into a mold, and then It was dried at ℃ for 24 hours, and sintered at 1050℃ for 3 hours to prepare a calcium phosphate ceramic porous scaffold.

[0030] The above-mentioned binder solution comprises: 5wt% of gelatin, 5wt% of polyvinylpyrrolidone, 5wt% of polyvinyl alcohol and 5wt% of methylcellulose, and the balance is distilled water.

Embodiment 3

[0032] The preparation method of the high specific surface area calcium phosphate ceramic porous support of the present embodiment comprises:

[0033] Dissolve the binder in water to obtain a binder solution with a concentration of 15wt%, mix the binder solution and β-tricalcium phosphate powder evenly in a mass ratio of 3:1, and then mix the hydrogen peroxide solution with β-phosphoric acid The mass ratio of tricalcium powder is 0.3:1, adding hydrogen peroxide solution with a concentration of 20wt% and mixing evenly, then using a microwave with a power of 700W for 15s, pouring the obtained mixed slurry into a mold, and then It was dried at ℃ for 18 hours, and sintered at 1020℃ for 4 hours to prepare a calcium phosphate ceramic porous scaffold.

[0034] The above-mentioned binder solution includes: 4wt% gelatin, 3.5wt% polyvinylpyrrolidone, 3.5wt% polyvinyl alcohol and 4wt% methylcellulose, and the balance is distilled water.

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Abstract

The invention discloses a calcium phosphate ceramic porous support with a high specific surface area and a preparation method thereof, belonging to the field of biological materials. In the present invention, the binder solution and β-tricalcium phosphate powder are uniformly mixed, and then a foaming agent is added to mix uniformly, and then microwave treatment is performed, and the obtained mixed slurry is poured into a mold, and then dried and sintered to obtain phosphoric acid Calcium Ceramic Porous Scaffold. The preparation process of the present invention is simplified, the preparation period is greatly shortened, the preparation process is simple, the dependence on equipment is reduced, the support is easy to form, and the shape can be customized according to needs, and the support has uniform aperture and through-hole channels.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a calcium phosphate ceramic porous support with a high specific surface area and a preparation method thereof. Background technique [0002] Bone defect is a common clinical disease. According to statistics, there are more than 1 million patients with bone defect caused by disease, trauma, tumor, etc. every year in my country. Although bone has the ability to self-regenerate and repair, it is often difficult to heal the defect only by self-repair, and the repair of large bone defects is still a difficult point in orthopedic treatment. Compared with traditional bone repair solutions (autologous bone, allogeneic bone and xenogeneic bone materials), artificial bone repair materials have the advantages of no immune rejection, no risk of animal origin, low cost, wide range of sources, and exempt patients from secondary surgery. It is considered to be one of the most promising bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/12A61L27/22A61L27/16A61L27/20
Inventor 汪建新陈太军王莹莹魏冉徐啟真劳成文吴佳杭冯波翁杰
Owner SOUTHWEST JIAOTONG UNIV