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Preparation method of a multifunctional coating for anticoagulant and antiinfection and multifunctional material for anticoagulant and antiinfection

A multi-functional coating and anti-infection technology, which is applied in the field of medical materials, can solve the problem of surface albumin immobilization with limited effect, and achieve the effect of simple and easy preparation method and controllable thickness

Active Publication Date: 2021-05-07
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of using albumin to modify the surface of materials generally uses covalent grafting to immobilize albumin, and its effect is limited by the amount of albumin immobilized on the surface.

Method used

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  • Preparation method of a multifunctional coating for anticoagulant and antiinfection and multifunctional material for anticoagulant and antiinfection
  • Preparation method of a multifunctional coating for anticoagulant and antiinfection and multifunctional material for anticoagulant and antiinfection

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preparation example Construction

[0019] A method for preparing an anticoagulant and anti-infection multifunctional coating provided by an embodiment of the present invention comprises the following steps:

[0020] S1, preparation of coating raw material solution

[0021] The albumin, solvent, modifying agent and antibiotic are blended to form a coating raw material solution, wherein the modifying agent is a strong reducing agent or a strong oxidizing agent. In the embodiment of the present invention, a strong reducing agent or a strong oxidizing agent is used to transform the albumin from an α-helical structure to a β-sheet structure, so that the β-sheet structure can be used to endow the albumin with spontaneous assembly properties, and albumin and antibiotics can interact through static electricity or hydrogen bonds. Achieving co-assembly.

[0022] Specifically, in the coating material solution, the concentration of albumin is 0.001-100 mg / mL, and the concentration of antibiotics is 0.001-50 mg / mL. Prefer...

Embodiment 1

[0037] This embodiment provides a method for preparing an anticoagulant and anti-infection multifunctional coating, which includes the following steps:

[0038] After mixing bovine serum albumin aqueous solution with concentrated sulfuric acid, adjust the pH to be about 2, then add vancomycin aqueous solution, add water to adjust the concentration of bovine serum albumin in the mixed solution to 0.001mg / L, and the concentration of vancomycin is 0.001mg / L, the mass fraction of concentrated sulfuric acid is 0.01%.

[0039] Place the cardiac venous catheter in the mixed solution and soak for about 1 second at a temperature of 0°C. The samples were then washed and dried once.

Embodiment 2

[0041] This embodiment provides a method for preparing an anticoagulant and anti-infection multifunctional coating, which includes the following steps:

[0042] After mixing human serum albumin aqueous solution with nitric acid, adjust the pH to about 14, then add daptomycin aqueous solution, add water to adjust the concentration of human serum albumin in the mixed solution to 100mg / L, and the concentration of daptomycin is 50mg / L, the mass fraction of nitric acid is 50%.

[0043] Place the nickel-titanium alloy inferior vena cava filter in the mixed solution and soak it at 100°C for 2 days. The samples were then washed and dried once.

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Abstract

The invention discloses a preparation method of an anti-coagulation and anti-infection multifunctional coating and an anti-coagulation and anti-infection multifunctional material, and relates to the technical field of medical materials. The preparation method of the anticoagulant and anti-infection multifunctional coating comprises: blending albumin, a solvent, a modifier and an antibiotic to form a coating raw material solution; soaking the base material in the coating raw material solution; wherein the modifier is Strong reducing agent or strong oxidizing agent. The anticoagulant and anti-infection multifunctional material includes a base material and a functional coating formed on the base material. The functional coating contains albumin and antibiotics, and the albumin has a β-sheet structure. The coating of the multifunctional material has a good bonding force with the base material, and has good anticoagulation and anti-infection properties.

Description

technical field [0001] The invention relates to the technical field of medical materials, and in particular to a preparation method of an anticoagulant and anti-infection multifunctional coating and an anticoagulant and anti-infection multifunctional material. Background technique [0002] The application of implanted / interventional devices in contact with blood (such as artificial hearts, ventricular assist devices, pacemakers, central venous catheters) and extracorporeal medical devices (including external circuits and indwelling catheters) has saved millions of lives. However, its clinical application is still accompanied by two major complications of thrombosis and infection, resulting in increased morbidity, mortality and medical costs. Clinically, the common means to prevent thrombosis and infection is to use anticoagulant drugs such as heparin, antibiotics, etc. for drug treatment. Unfortunately, this systemic administration increases the risk of bleeding and heparin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/16A61L33/12
Inventor 王娟杨作霞程龙飞
Owner SHAANXI NORMAL UNIV