Pharmaceutical composition for treatment of oral ulcers and preparation method of pharmaceutical composition

A technique for oral ulcers and compositions, which is applied in the field of pharmaceutical compositions for the treatment of oral ulcers and its preparation, can solve the problems of poor curative effect, inability to eliminate pain and discomfort of patients, long healing period, etc., and achieve drug resistance, Improves healing ability, fast-acting effect

Inactive Publication Date: 2019-06-21
GUANGZHOU PHGO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many medicines for the treatment of oral ulcers on the market, these medicines have a long cure period and poor curative effect, and cannot eliminate the patient's pain and improve the patient's discomfort in a short period of time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] The preparation method of this yolk immunoglobulin composition comprises:

[0023] (1) Bacteria after inactivation treatment are divided into 25-40% of Streptococcus mutans, 15-20% of Staphylococcus aureus, 10-15% of Pseudomonas aeruginosa, 10-15% of Escherichia coli, cluster A and type B hemolytic chain 10-15% of cocci and 10-15% of Candida albicans are mixed to obtain a strain mixture; after dissolving the strain mixture, a composite antigen is obtained;

[0024] Further, after dissolving the bacterial strain mixture, the step of preparing the composite antigen comprises: mixing the dissolved bacterial strain mixture with Freund's adjuvant at a mass ratio of 1:0.5-1.5 to obtain a milky whole bacterial composite antigen, and then Milky whole bacteria compound antigen is pulverized and homogenized.

[0025] Further, the proportion of each colony in the preparation of the strain mixture is: Streptococcus mutans 30-35%, Staphylococcus aureus 16-19%, Pseudomonas aeruginos...

Embodiment 1

[0047] The present embodiment provides a kind of pharmaceutical composition for treating oral ulcer, it comprises:

[0048] Yolk immunoglobulin composition 6Kg, Coptidis 9Kg, Polygonum cuspidatum 7Kg, Verbena 2Kg, Borneol 5Kg, Alum 7Kg, Acetylsalicylic acid 7Kg, Pipergrass 2Kg and Burnet 3Kg.

[0049] Its preparation method includes:

[0050] Mix Coptidis rhizome, Polygonum cuspidatum, Verbena, Flying grass and Burnet, mix with 65% ethanol according to the material-to-liquid ratio of 1:7, and extract the medicinal liquid by sonic vibration extraction method. The power of the ultrasonic vibration extraction method is 95KHz, and the time is 40min;

[0051] After the medicinal solution is mixed with alum and borneol, it is concentrated to obtain an extract;

[0052] Then the extract is mixed with egg yolk immunoglobulin composition and acetylsalicylic acid, and dried in vacuum.

[0053] Wherein, the preparation method of yolk immunoglobulin composition comprises:

[0054] Bacte...

Embodiment 2

[0057] The present embodiment provides a kind of pharmaceutical composition for treating oral ulcer, it comprises:

[0058] Yolk immunoglobulin composition 10Kg, Coptis chinensis 6Kg, Polygonum cuspidatum 3Kg, Verbena 5Kg, Borneol 8Kg, Alum 3Kg, Acetylsalicylic acid 3Kg, Pipergrass 5Kg and Burnet 6Kg.

[0059] Its preparation method includes:

[0060] Mix Coptidis Rhizoma Coptidis, Polygonum cuspidatum, Verbena, Flying grass and Burnet, mix with 70% ethanol according to the ratio of material to liquid 1:6, and extract the medicinal solution by sonic vibration extraction method, the power of ultrasonic vibration extraction method is 100KHz, and the time is 20min;

[0061] After the medicinal solution is mixed with alum and borneol, it is concentrated to obtain an extract;

[0062] Then the extract is mixed with egg yolk immunoglobulin composition and acetylsalicylic acid, and freeze-dried at low temperature to obtain the product.

[0063] Wherein, the preparation method of y...

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PUM

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Abstract

The invention provides a pharmaceutical composition for the treatment of oral ulcers and a preparation method of the pharmaceutical composition and relates to the field of drugs. The pharmaceutical composition comprises, by weight, 6-12 parts of yolk immunoglobulin composition, 5-9 parts of coptis chinensis, 2-7 parts of polygonum cuspidatum, 2-7 parts of verbena, 5-9 parts of borneol, 2-7 parts of alumen, 2-7 parts of acetylsalicylic acid, 2-7 parts of herba euphorbiae hirtae and 3-7 parts of sanguisorba officinalis. The preparation method includes: mixing the coptis chinensis, polygonum cuspidatum, verbena, herba euphorbiae hirtae and sanguisorba officinalis with 65-75% of ethyl alcohol and extracting liquid by an acoustic shock extraction method; mixing the liquid with the alumen and borneol to obtain an extract after concentration; mixing the extract with the yolk immunoglobulin composition and acetylsalicylic acid before vacuum drying. The pharmaceutical composition has the advantages of strong antibacterial and anti-inflammatory effects and a good bactericidal effect on a variety of pathogenic bacteria, and is not easy to produce drug resistance, fast in treatment of the oralulcers and good in curative effect for the treatment of the oral ulcers.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral ulcer", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks keratinization Layers or poorer keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] Although there are many medicines for the treatment of oral ulcers on the market, these medicines have a long cure period and poor curative effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K39/395A61P1/02A61K31/045A61K31/616A61K33/06A61K36/85
Inventor 农定猛符美燕蒙晓蒙永祥叶梦婕
Owner GUANGZHOU PHGO BIOTECH
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