Hydrogel nanoparticles for measuring ionizing radiation dose and method of preparation thereof

An ionizing radiation and nanoparticle technology, which is used in measurement devices, radiation measurement, chemical instruments and methods, etc., can solve the problems of large measurement deviation, easy diffusion of ions, and time-consuming reading, achieving good stability and solving low sensitivity. , the effect of low error rate

Active Publication Date: 2021-05-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the above ionizing radiation dose measurement methods have some disadvantages, for example, when using silicon diodes, external circuits are often required
The material has disadvantages such as high dependence on ray angle, energy and dose rate, temperature and use time have a great influence on its measurement sensitivity, poor tissue equivalence (the measured dose needs to be converted by a correction factor), and the measurement deviation of different batches is large
Thermoluminescent dose tablets have poor mechanical strength and are fragile, and need to be fixed on the skin with an external medium, which increases the risk of inflammation. The environment (light, heat) has a great impact on the accuracy of dose measurement, and the dose reading is complicated
Field response tubes are expensive to use and need to be applied with high pressure, which is not suitable for in-situ dose measurement
The preparation of the above dosimeters often requires complex and advanced processes, which also limits their application
[0006] In addition, the 3D water tank is large in size, low in position resolution, and time-consuming to read
Fe in ferrous sulfate gel dosimeter 3+ Ions are easy to diffuse, poor position resolution
Polymer gel dosimeters have a large influence on the measurement of oxygen and temperature, and the method is not sensitive to low doses
Professor Rege and The metal-doped gel dosimeter reported by the professor's research group has poor linear response in the low-dose region, and the introduction of heavy metal ions reduces the tissue equivalence of the material, thereby affecting the accuracy of dose measurement

Method used

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  • Hydrogel nanoparticles for measuring ionizing radiation dose and method of preparation thereof
  • Hydrogel nanoparticles for measuring ionizing radiation dose and method of preparation thereof
  • Hydrogel nanoparticles for measuring ionizing radiation dose and method of preparation thereof

Examples

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Embodiment 1

[0057] The preparation of embodiment 1 hydrogel nanoparticles

[0058] The present embodiment provides a kind of hydrogel nanoparticle and preparation method thereof based on colorimetric fluorescence method for measuring ionizing radiation dose, comprising the following steps:

[0059] 1. Dissolve 0.5 mg APMA and 1 mg TAMRA-SE in 250 μL of sodium borate buffer (pH=9.5), stir at room temperature in the dark for 24 hours to obtain APMA-modified TAMRA (hereinafter referred to as TAMRA-APMA), and store at 4°C for later use. Its reaction schematic diagram is as follows figure 1 shown.

[0060] 2. Dissolve 300mg of AAm, 180mg of BIS and 300mg of APMA in 2mL of deionized water, then add to 250μL of TAMRA-APMA prepared in step 1, and filter the mixture with a 0.2μm filter to obtain a reaction mixture.

[0061] 3. Add 3.2mL of surfactant Brij 30 and 1.59g of AOT into 43mL of n-hexane and stir to dissolve. At the same time, add 2mL of the reaction mixture prepared in step 1, N 2 Sti...

Embodiment 2

[0066] The preparation of embodiment 2 hydrogel nanoparticles

[0067] The present embodiment provides a kind of hydrogel nanoparticle and preparation method thereof based on colorimetric fluorescence method for measuring ionizing radiation dose, comprising the following steps:

[0068] 1. Dissolve 1.25 mg of rhodamine b-glucan (RITC-Dextran), 300 mg of AAm, 180 mg of BIS and 300 mg of APMA in 2 mL of deionized water, and then filter with a 0.2 μm filter to obtain a reaction mixture. Rhodamine b-glucan in this step can also be replaced by Texas Red-glucan or rhodamine b-isothiocyanate.

[0069] 2. Add 3.2mL of surfactant Brij 30 and 1.59g of AOT into 43mL of n-hexane, stir and dissolve, and add 2mL of the reaction mixture prepared in step 1 at the same time, N 2 Stir at high speed under the atmosphere for 20min, then add 80μL of 10% APS and 60μL of tetramethylethylenediamine, N 2 The reaction was carried out for 2 h under the atmosphere to obtain PAA-based hydrogel nanoparti...

Embodiment 3

[0073] The preparation of embodiment 3 hydrogel nanoparticles

[0074] Hydrogel nanoparticles for measuring ionizing radiation dose based on colorimetric fluorescence method were prepared according to the method of Example 1, except that AAm in step 2 could be replaced by hydroxyethyl methacrylate of equimolar mass.

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Abstract

The invention relates to the technical field of biomedical polymer materials and ionizing radiation measurement, in particular to a hydrogel nanoparticle for measuring ionizing radiation dose and a preparation method thereof. The preparation method includes the following steps: mixing a fluorescent substance insensitive to ionizing radiation, a hydrophilic monomer, a cross-linking agent and a functional monomer in water to obtain a mixed solution; adding the mixed solution to the surfactant and n-hexane In the alkane system, in the presence of an initiator and a catalyst, an inverse emulsion polymerization reaction occurs in an inert atmosphere, and hydrogel nanoparticles are obtained after the reaction is complete; at pH 5.5, an activator is used to activate the ionizing radiation-sensitive The fluorescent substance is fully activated and then reacted with the hydrogel nanoparticle at a pH of 7.4 at 4-30° C. After the reaction is complete, the hydrogel nanoparticle for measuring the ionizing radiation dose is obtained.

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials and ionizing radiation measurement, in particular to a hydrogel nanoparticle for measuring ionizing radiation dose and a preparation method thereof. Background technique [0002] Tumors seriously endanger human health and survival. Radiation therapy uses ionizing radiation to treat tumors. At present, the rapid development of radiotherapy technology has entered the stage of precise positioning, precise planning and precise treatment. However, due to the relatively backward development of radiotherapy dose measurement, the inaccurate dose delivery has brought serious irreversible consequences to patients and seriously affected the implementation of precise radiotherapy technology. [0003] Usually, ionizing radiation dose measurement uses silicon diodes, thermoluminescent dose tablets, field effect tubes, etc. Among them, by measuring the number of electron-hole pairs generat...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C08J3/075C08F220/56C08F220/60C08F222/38C08F8/10C08F251/00C08F220/20C08F226/02C08F222/14C08L33/26C08L33/24C08L51/02G01T1/161C09K11/02C09K11/06
Inventor胡亮李文翔赵睿
OwnerSUZHOU UNIV