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High molecular composite material for antibacterial medical catheter and preparation method of material

A technology of polymer materials and composite materials, which is applied in the field of polymer composite materials for antibacterial medical catheters and its preparation, can solve the problems of large amount of nano-ZnO added, difficulty in mixing ZnO and TPU particles uniformly, and difficult cost control. Good antibacterial, low cost, and the effect of improving molding performance

Inactive Publication Date: 2019-06-28
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent (publication number: CN104139584A) discloses a nano-ZnO and TPU double-layer antibacterial composite material, the base layer is polyurethane resin, and the antibacterial layer is a nano-ZnO and TPU composite material. The performance and mechanical properties are good, but the preparation process limits the mixing of ZnO and TPU particles, and the addition of nano-ZnO is large, and the cost is difficult to control

Method used

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  • High molecular composite material for antibacterial medical catheter and preparation method of material
  • High molecular composite material for antibacterial medical catheter and preparation method of material
  • High molecular composite material for antibacterial medical catheter and preparation method of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Polymer Composite Materials for Antibacterial Medical Catheters

[0028] Measure 200ml of deionized water into the beaker, successively measure 14.87g of zinc nitrate hexahydrate, 3.5g of hexamethylenetetramine, 5.71g of ammonia water, and 0.12g of trisodium citrate into deionized water, and stir for 10min; In a water bath, preheat at 65°C for 0.5h, then heat at 85°C for 12h; take out the residue in the beaker, filter 3 times on a Buchner funnel with deionized water and ethanol, and then put it in an oven to dry at 60°C for 24h , to obtain a white powdery solid; put it into a sintering furnace and calcinate at 200°C for 12 hours to obtain a light yellow powder, that is, nano-ZnO powder; grind it at room temperature for 30 minutes to below 300 mesh, and pack it for use.

[0029] Measure 19.0ml of tetrahydrofuran into a beaker with a capacity of 25ml and place it on a magnetic stirrer, weigh 1.90g of TPU into the beaker, turn on the magnetic stirrer, set th...

Embodiment 2

[0031] Preparation and antibacterial property test of nano ZnO / TPU antibacterial composite material

[0032] The nanometer ZnO / TPU composite material that embodiment 1 prepares to obtain three kinds of different formulations is thinly cut into 1cm 2 For the sample, place the sample in an EP tube and place it in an incubator at 37°C, incubate 3ml of culture solution and 100μl of bacterial solution with the sample and the petri dish for 24 hours, take out the sample and gently rinse it with fresh PBS to remove the sample. Sample non-adherent bacteria; placed in 3ml PBS and ultrasonically treated for 5 minutes to separate the adhered bacteria, then inoculated the sample into tryptone soybean agar, incubated at 37°C for 24 hours, calculated the colony forming unit (CFU), and measured The total number of live bacteria on the surface of the sample. The results show that, referring to Table 1, the antibacterial rates of nano-ZnO / TPU composites to Escherichia coli can reach 88.84% (ZnO...

Embodiment 3

[0034] Anti-adhesion performance test of nano-ZnO / TPU antibacterial composites.

[0035] Nano ZnO / TPU composite materials of different proportions are prepared according to Example 1, and thinly cut into 1cm 2 The samples were tested with the OCA25LHT-SV contact angle measuring instrument to measure their wetting properties. The results showed that the interface wetting angle of the nano-ZnO / TPU composite material invented by this patent can be increased from 63.4° to 102.8° at the maximum compared with the pure TPU material. °, the hydrophobic performance is obviously improved, and it has good anti-adhesion performance.

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Abstract

The invention belongs to the field of medical materials and particularly relates to a high molecular composite material for an antibacterial medical catheter and a preparation method of the material.The anti-adhesion material comprises a medical high molecular material and antibacterial nano particles prepared through a sol-gel method, the antibacterial nano particles are evenly dispersed througha physical method and loaded on a high molecular substrate material, and the anti-germ-adhesion function is achieved. The method is easy to implement, and the composite material has good anti-germ performance, anti-adhesion performance and durability, good self-lubrication performance and low melting viscosity and is easily formed and processed; the material is suitable for medical catheters, wire products and instruments thereof.

Description

technical field [0001] The invention relates to a polymer composite material for an antibacterial medical catheter and a preparation method thereof, belonging to the field of medical materials. Background technique [0002] Modern medical catheters are indispensable tools in the process of clinical diagnosis and treatment, but because they are extremely susceptible to microbial infections such as bacteria and fungi, they may cause tissue and body lesions due to contact with the human body during use, thereby causing serious health problems to patients. Great harm. The route of infection of bacteria to catheters is mainly through surface adhesion. Although preoperative drug elution and antibiotics can be used to avoid bacterial infection, the former has limited antibacterial effect, while the latter is likely to cause drug resistance in the human body, etc. Negative Effects. Therefore, the development of stable antibacterial and anti-adhesion medical materials becomes a mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/14A61L29/16
Inventor 刘东雷艾凡荣辛勇李文超王学亮曹传亮周奎
Owner NANCHANG UNIV