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Methods and compositions for prostate cancer diagnosis and treatment

A technology for prostate cancer and prostate, applied in the field of multiple compositions of a patient, can solve problems such as uselessness

Inactive Publication Date: 2019-07-16
MIR SCI LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies provide a valuable data set for comparing the complement of various ncRNAs expressed in prostate cancer and peritumoral benign tissue, but are critical for a study that would predict tumor progression prior to clinical intervention. The rational design of group ncRNA is useless
The technique is also flawed as a general screening technique because it requires rapid freezing of material

Method used

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  • Methods and compositions for prostate cancer diagnosis and treatment
  • Methods and compositions for prostate cancer diagnosis and treatment
  • Methods and compositions for prostate cancer diagnosis and treatment

Examples

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example

[0070] Several examples of various embodiments of the invention are provided in the following several examples. The various examples that follow are presented by way of illustration only and to assist one of ordinary skill in using the invention. These examples are not intended to limit the stated scope of the invention in any way.

example 1

[0071] Example 1: Prognostic platform for core needle aspiration sections of prostate cancer.

[0072] Standard operating protocol for the extraction and characterization of miRNAs and snoRNAs (collectively ncRNAs) from examination of multiple core-needle aspiration sections. Lists of informative ncRNAs have historically been used to develop such prognostic diagnoses. Waterfall plots were generated from multiple core aspiration sections using the compared ncRNA expression dataset and differentiated aggressive from lingering tumors.

example 2

[0073] Example 2: RNA Extracts from FFRE Core Needle Biopsies.

[0074] The standard processing steps describe the extraction process and processing of sections of delabeled and barcoded core aspiration sections to obtain RNA material after sending the sections to the laboratory.

[0075] The sample must comprise at least two FFPE tissue sections with a thickness of 10 microns from a plurality of material from a core needle aspiration section of the prostate.

[0076] RNA extraction:

[0077] A. Preparation

[0078] When handling or transporting multiple samples, all laboratory personnel should wear gloves and decontaminate the work environment with an appropriate detergent.

[0079] Use RNase, DNase-free multiple tubes, and multiple filter tips when handling multiple RNA materials and during all extractions. They were safely disposed of in biohazard boxes and were no longer used for any purpose.

[0080]Sample tubes, RNA extraction columns, and final elution tubes should ...

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Abstract

The present invention relates to compositions and methods for diagnosing, prognosing, monitoring, and treating a patient with prostate cancer. In particular, the invention relates to ncRNAs as diagnostic markers for determination of proper treatment administration.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application 62 / 347,600, filed June 8, 2016, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention relates to compositions and methods for diagnosing, prognosing, monitoring and treating a patient suffering from prostate cancer. In particular, the invention relates to ncRNAs and miRNAs as diagnostic markers for identifying suitable therapeutic administrations. Background technique [0004] In November 2012, the U.S. Preventive Services Task Force recommended prostate-specific antigen (PSA) screening for prostate cancer in healthy men because there was "moderate to high It does more harm than good" (Moyer, 2012). While the working group acknowledges that the test is sensitive, accurate, and has a low false positive rate, they argue that "there is little evidence that PSA screening saves lives, but instead many men s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/68C12Q2600/106C12Q2600/112C12Q2600/118C12Q2600/158C12Q1/6886A61P35/00G16H50/30G16H50/20C12Q1/6825
Inventor 马丁·添尼斯伍德王慰齡·温妮格雷戈里·迪安索塔克·康克林
Owner MIR SCI LLC