A hydrothermal sterilization method for in-situ synthesis of antibacterial silver phosphate on the surface of hydroxyapatite coating

Abstract

The invention discloses a hydrothermal sterilization method capable of performing in situ synthesis of antibacterial silver phosphate on a hydroxyapatite coating surface. The hydrothermal sterilization method comprises the following steps of placing a basal body of which the surface is covered with a hydroxyapatite coating in a container, adding a silver acetate solution into the container, and performing sealing; performing heating sterilization on the container; and after the heating sterilization, taking out the basal body covered with the hydroxyapatite coating from the container, and performing flushing under sterile environment. Through the adoption of the hydrothermal sterilization method disclosed by the invention, the purpose of sterilizing an implant covered with the hydroxyapatite coating is realized, and silver phosphate in in-situ growth is also synthetized on the surface of the implant; the coating has long-lasting antibacterial property, pathogenic bacteria can be prevented from proliferation and formation of biomembranes on the surface of the coating, the infection possibility is reduced, and the survival possibility of the implant is increased; and operation stepsare simple, conventional sterilization equipment is used, the treatment cycle is short, and the hydrothermal sterilization method is especially suitable for clinical application.

Description

technical field [0001] The invention relates to a sterilization method for hydroxyapatite, in particular to a hydrothermal sterilization method for in-situ synthesis of antibacterial silver phosphate on the surface of a plasma sprayed hydroxyapatite coating. Background technique [0002] Hydroxyapatite (HA) has excellent osteoconductivity, and is the best choice for biological coating on the surface of intraosseous implants such as dental implants and artificial joints. There are many methods for preparing hydroxyapatite coatings, including biomimetic mineralization, sol-gel, hydrothermal synthesis, etc. Among them, the plasma spraying method can prepare coatings with larger thickness and stronger adhesion due to its high production efficiency. It is the mainstream method to prepare hydroxyapatite coating on the surface of implants at present. However, while HA provides good support for bone growth, it also provides a good environment for pathogenic bacteria, such as Staphy...

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Problems solved by technology

Although the above-mentioned approaches can also realize the doping of silver, there are certain shortcomings, such as, the ion exchange method takes a long time, the loading of silver in hydroxyapatite is limited, and the release is faster; the antibacterial properties of silver nanoparticles are not as good as those of the same amount Silver ions are more obvious; although the co-deposition method produces silver phosphate with durable antibacterial properties, it needs electric field guidance, and the bonding strength between the coating and the substrate is insufficient; silver-doped co-spraying reduces the crystallinity of HA, etc.

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