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Selenium-containing chalcone derivative compound 1, its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs

A selenium-chalcone, non-alcoholic technology, which is applied in the field of preparation of new compounds and medicines, can solve problems such as undiscovered patent publications, and achieve the effect of simple purification methods, simple synthesis and purification methods

Active Publication Date: 2021-06-04
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Selenium-containing chalcone derivative compound 1, its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs
  • Selenium-containing chalcone derivative compound 1, its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs
  • Selenium-containing chalcone derivative compound 1, its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs

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Embodiment Construction

[0039] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0040] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0041] A selenium-containing chalcone derivative Compound 1, the structural formula of the selenium-containing chalcone derivative Compound 1 is as follows:

[0042]

[0043] Preferably, the activity of the selenium-containing chalcone derivative Compound 1 on nonalcoholic steatohepatitis is evaluated at the cellular level, and the results show that the compound has anti-nonalcoholic steatohepatitis activity in vitro, and at the same time, the compound has anti-nonalcoholic steatohepatitis activity in vivo. The lev...

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Abstract

The present invention relates to a selenium-containing chalcone derivative Compound 1. The structural formula of the selenium-containing chalcone derivative Compound 1 is as follows: the selenium-containing chalcone derivative Compound 1 has the drug activity of non-alcoholic steatohepatitis, The synthesis and purification method is simple, has nonalcoholic steatohepatitis activity, can be used for anti-nonalcoholic steatohepatitis treatment, and can be applied to the preparation of nonalcoholic steatohepatitis medicine.

Description

technical field [0001] The invention belongs to the technical field of preparation of new compounds and medicines, in particular a selenium-containing chalcone derivative Compound 1 and its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs. Background technique [0002] The biopharmaceutical activity of chalcone compounds is more obvious and effective and has a good plastic structure, which can be combined with different drug intermediates and receptors in organisms to exhibit its unique biological activities. For example: anti-gastric ulcer, anti-malarial, anti-bacterial, anti-allergic, anti-HIV, anti-cancer, anti-hair loss and trigger hair growth, scavenging free radicals to achieve anti-oxidation, lowering blood fat, lowering blood pressure, anti-nonalcoholic steatohepatitis, etc. [0003] Selenium is a multifunctional life nutrient. It is often used for more than 40 diseases such as tumor, cancer, Keshan disease, Kaschin-Beck disease, cardio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C391/02A61P1/16
CPCA61P1/16C07C391/02
Inventor 滕玉鸥郁彭赵连波赵玙璠苗爱郝磊傅玉鹏丁颖向岑芦逵
Owner TIANJIN UNIV OF SCI & TECH
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