Preparation method of 2,5-disubstituted furan derivatives

A furan derivative and disubstituted technology, applied in 2 fields, can solve problems such as unsatisfactory effect on regio and stereoselectivity, and achieve the effects of good regioselectivity, wide substrate range and high yield
CN110143935AActive Publication Date: 2019-08-20HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2019-08-20

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Abstract

The invention discloses a preparation method of 2,5-disubstituted furan derivatives. One carbon-carbon bond is cut off, at the same time, a novel carbon-carbon bond is established, cyclization reactions are carried out to obtain the 2,5-disubstituted furan derivatives, which have good regioselectivity. The method has the advantages of easily available raw materials, high yield, mild reaction conditions, short reaction time, wide substrate range, strong reaction specificity, and convenient and green post-treatment.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 2,5-disubstituted furan derivatives. Background technique

[0002] 2,5-disubstituted furan is one of the basic organic structural units, and it also widely exists in natural products, and is also an important intermediate in industrial organic synthesis, widely used in many fields such as medicine, food spices, and pesticides. For example, furazolidonum (furazolidonum), which has significant antibacterial activity, has obvious drug activity against enteritis, bacillary dysentery and colon cancer and other intestinal infection diseases. Active and environmentally friendly, it is widely used in agriculture. Therefore, the synthesis of 2,5-disubstituted furan is one of the important contents of organic chemistry, and wherein, the synthetic method of 2,5-disubstituted furan in the prior art is still not quite as effective in regio and st...

Claims

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