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Roxithromycin micro-tablet capsule and making method thereof

A technology for roxithromycin and a manufacturing method, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as difficulty in controlling the dissolution rate of capsules, consistency, and difficulty in the dissolution profile of roxithromycin tablets. , to achieve a good effect of dissolution

Inactive Publication Date: 2019-08-23
HAINAN HAILI PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the process of studying roxithromycin capsules, it is found that the dissolution rate of the capsules is often difficult to control, and it is difficult to be consistent with the dissolution curve of the original roxithromycin tablets

Method used

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  • Roxithromycin micro-tablet capsule and making method thereof
  • Roxithromycin micro-tablet capsule and making method thereof
  • Roxithromycin micro-tablet capsule and making method thereof

Examples

Experimental program
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Effect test

Embodiment 7

[0030] The manufacture method of the roxithromycin microtablet capsule of the present embodiment, it comprises the following steps:

[0031] S1: The step of preparing an adhesive; in S1, mix Poloxamer 188, purified water, and Povidone K30, and stir evenly to obtain an adhesive, with 8.4 parts of Povidone K30 and 0.3 parts of Poloxamer 188. share;.

[0032] S2: the soft material step that contains roxithromycin, in S2, take by weighing roxithromycin, cornstarch, L-HPC, make soft material with binder, roxithromycin is 303.9 parts, cornstarch is 53.4 parts, L-HPC 39.3 parts;

[0033] S3: wet sizing step;

[0034] S4: drying step, fluidized bed drying;

[0035] S5: dry sizing step;

[0036] S6: the total mixing step, in S6, add colloidal silicon dioxide, talcum powder, magnesium stearate and mix evenly, the colloidal silicon dioxide is 3.75 parts, the talcum powder is 4.5 parts, and the magnesium stearate is 3.75 parts;

[0037] S7: tablet compression step to obtain microtabl...

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Abstract

The invention relates to a roxithromycin micro-tablet capsule and a making method thereof. The roxithromycin micro-tablet capsule comprises a capsule shell, and the capsule shell is loaded with roxithromycin micro-tablets. According to the roxithromycin micro-tablet capsule and the making method thereof, roxithromycin is made into the micro-tablets, then a capsule body is filled with the roxithromycin of the micro-tablet structure, and after testing, the preparation has a high dissolution rate and meets the requirement.

Description

technical field [0001] The present invention relates to a kind of manufacturing method of capsule medicine, particularly a kind of roxithromycin microtablet capsule and its manufacturing method. Background technique [0002] Roxithromycin, English aliases as Claramid, Rulid, western medicine, is a new generation of macrolide antibiotics, mainly acting on Gram-positive bacteria, anaerobic bacteria, chlamydia and mycoplasma. Its antibacterial effect in vitro is similar to that of erythromycin, and its antibacterial effect in vivo is 1 to 4 times stronger than that of erythromycin. [0003] Roxithromycin capsules, the traditional indications are pharyngitis and tonsillitis caused by streptococcus pyogenes, sinusitis, otitis media, acute bronchitis, acute exacerbation of chronic bronchitis, mycoplasma pneumoniae or chlamydia pneumoniae Pneumonia; urethritis and cervicitis caused by Chlamydia trachomatis; skin and soft tissue infection caused by sensitive bacteria. [0004] Dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/20A61K31/7048A61P31/04
CPCA61K9/4808A61K9/4866A61K31/7048A61P31/04
Inventor 许丹青余国新耿亮
Owner HAINAN HAILI PHARMACEUTICAL CO LTD