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Hoof nail polypeptide and preparation process thereof

A preparation process and a technology for hoof nails, which are applied in the field of hoof nail polypeptides and their preparation processes, can solve the problems of low yield of hoof nail polypeptides and the like, and achieve the effect of improving the yield.

Inactive Publication Date: 2019-09-20
SHANDONG ZHONGTAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a preparation process of hoof nail polypeptide, aiming to improve the problem of low yield in the preparation process of hoof nail polypeptide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0012] The embodiment of the present invention provides a preparation process of hoof nail polypeptide, comprising the following steps:

[0013] The hoof nails used in the embodiment of the present invention are pig hoof nails, but hoof nails of other animals can also be used to prepare the hoof hoof polypeptides.

[0014] First, the hoofnails are pretreated, which includes manual screening, soaking, drying and crushing.

[0015] Manual screening, removal of debris, and selection of hoof nails with complete structure and no mildew to ensure the quality of hoof nail peptides.

[0016] The soaking includes soaking in a sodium chloride solution with a mass percentage of 3-6% for 30-60 minutes, and then washing with clear water. Soaking in 3-6% sodium chloride solution can better remove impurities in the hoof nails through the effect of osmotic pressure, and ensure the quality of the hoof nail polypeptides obtained by extraction.

[0017] Drying includes draining the washed hoof...

Embodiment 1

[0050] Weigh 20kg of dried pig's trotters, manually remove impurities, soak and wash with 100L 5% sodium chloride solution for 60 minutes, rinse with purified water, drain, dry at 80°C for 3 hours, and then crush into 10-20 mesh coarse particles. Weigh the hoof nail coarse grain again to be 19.3kg, put it in a stainless steel bucket, add 5 times of purified water, and then add 193g of sodium hydroxide, stir well and place it in an autoclave cabinet for high-pressure treatment for 2 hours, and the control pressure is 0.1MPa . After the high-pressure treatment is completed and left to cool, use 2mol / L to 7.5, let it stand for 1 hour, sieve and filter with a 200-mesh pulp sieve to remove residue, and collect 92L of filtrate. Turn on the multi-stage membrane filtration equipment, install the polyamide reverse osmosis membrane, turn on the raw water heater, control the water temperature to 45°C, start the high-pressure pump, and control the pressure difference between the inlet and...

Embodiment 2

[0052]Weigh 20kg of dried trotter carapace, manually remove impurities, soak and wash with 100L 5% sodium chloride solution for 30 minutes, rinse with purified water, drain, dry at 100°C for 1 hour, and grind into 10-20 mesh coarse grains. Weigh the hoof nail coarse grain again to be 19.5kg, put it in a stainless steel bucket, add 10 times of purified water, and then add 900g of sodium hydroxide, stir well and place it in an autoclave cabinet for high-pressure treatment for 2 hours, and the control pressure is 0.1MPa . After the high-pressure treatment is completed and allowed to cool, adjust the pH to 8.5 with 2 mol / L hydrochloric acid, let it stand for 1 hour, filter and remove residue with a 200-mesh sieve, and collect 210 L of filtrate. Turn on the multi-stage membrane filtration equipment, install the polyamide reverse osmosis membrane, turn on the raw water heater, control the water temperature to 50°C, start the high-pressure pump, and control the pressure difference be...

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Abstract

The invention relates to the technical field of animal medicinal material polypeptide extraction and separation, in particular to a hoof nail polypeptide and a preparation process thereof. The preparation process of the hoof nail polypeptide comprises the following steps: mixing hoof nails with an alkaline substance, hydrolyzing the mixture under a high-pressure condition, and then adjusting pH by using an acidic substance. The invention aims to solve the problem of low yield in a preparation process of the hoof nail polypeptide.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of polypeptides from animal medicinal materials, in particular to a hoof nail polypeptide and a preparation process thereof. Background technique [0002] The hoof of the pig (Susscrofa domestica Brisson) is referred to as the hoof of pigs, also known as pig hoof, pig hoof and pig zygote. Pig's trotter armor is a traditional Chinese medicinal material, which is salty in taste and non-toxic. It enters the Yangming Jing and has certain medicinal value. In "Shen Nong's Materia Medica", there is a record of the use of hoofnails as medicine. In the "Compendium of Materia Medica" of Ming Dynasty, there are "hanging hoofnails", "taste is salty and non-toxic, and it is mainly used to treat five hemorrhoids. Akagi-burning and smoke, to get rid of all evil sore gas" record. [0003] Modern pharmacological studies of traditional Chinese medicine have shown that trotter nails mainly contai...

Claims

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Application Information

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IPC IPC(8): C07K1/12
CPCC07K1/12
Inventor 董惠钧李向阳李华利刘红粉
Owner SHANDONG ZHONGTAI PHARMA