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Novel hypolipidemic compound extracted from radix acanthopanacis semticosi

A compound, the technology of Acanthopanax senticosus, applied in the field of medicine, can solve the problems of many side effects, unable to fundamentally prevent and regulate blood lipids, and achieve the effects of low biological toxicity, increasing high-density lipoprotein cholesterol, and significantly reducing blood lipids

Active Publication Date: 2019-09-27
河北省农林科学院经济作物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs used can only play a role in controlling blood lipids, and have many side effects, so they cannot fundamentally prevent and regulate blood lipids.

Method used

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  • Novel hypolipidemic compound extracted from radix acanthopanacis semticosi
  • Novel hypolipidemic compound extracted from radix acanthopanacis semticosi
  • Novel hypolipidemic compound extracted from radix acanthopanacis semticosi

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preparation example Construction

[0023] The present invention also provides a preparation method of the compound shown in the formula I, which comprises the following steps:

[0024] (1) Take the dried Acanthopanax (Eleutherococcus senticosus), crush it, add 5 to 10 times the mass of 60% to 80% ethanol, heat and reflux for 1 to 3 times, each time for 2 to 4 hours, filter and combine The extract is concentrated under reduced pressure to 1 / 5 to 1 / 10 of the initial volume of the extract to obtain the ethanol extract of Acanthopanax;

[0025] (2) After the ethanol extract of Acanthopanax senticosus is suspended by adding 2 to 4 times the volume of water, it is extracted with equal volumes of cyclohexane and ethyl acetate successively, and the solvent is recovered under reduced pressure in each extract to obtain the cyclohexane part and Ethyl acetate moiety;

[0026] (3) The ethyl acetate part is separated with a silica gel column, followed by gradient elution with different proportions of petroleum ether-methano...

Embodiment 1

[0053] Embodiment 1: the preparation of the compound shown in formula I

[0054] (1) Get 3Kg of dried Acanthopanax medicinal material, add 24Kg of 75% ethanol after crushing, heat and reflux for extraction 3 times, each time for 4h, filter, combine the extract, concentrate under reduced pressure to 1 / 1 of the initial volume of the extract 5 get the ethanol extract of Acanthopanax;

[0055] (2) After the ethanol extract of Acanthopanax senticosus was suspended by adding 3 times the volume of water, it was extracted successively with equal volumes of cyclohexane and ethyl acetate, wherein cyclohexane extracted 2 times, ethyl acetate extracted 4 times, After merging the extracts of the same solvent, the solvent was recovered under reduced pressure to obtain a cyclohexane part (10.5 g) and an ethyl acetate part (22.3 g);

[0056] (3) Separate the ethyl acetate part with a silica gel column, and sequentially use 99:1, 95:5, 90:10, 80:20, 70:30, 60:40, 50:50 (v / v) of petroleum Eth...

Embodiment 2

[0065] Embodiment 2: the hypolipidemic activity test of the compound shown in formula I

[0066] The compound shown in formula I was formulated with 5% DMSO, 2% Tween80 and 93% physiological saline to prepare a 10mg / ml suspension liquid, and ultrasonically mixed before use; each animal was given an administration volume of 200 μl / 100g, given The dosage is 20mg / kg.

[0067] Experimental method: get 36 SD rats, half male and half male, randomly divided into 3 groups, respectively normal control group, model control group, compound group shown in formula I (ie administration group), 12 in each group. The model control group and the treatment group were fed with high-fat feed, and at the same time, the treatment group was given the compound shown in formula I (20 mg / kg) by intragastric administration once a day for 4 weeks; the model control group was administered by intragastric administration, etc. volume water. The normal control group was given normal feed. 1 hour after the...

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Abstract

The invention relates to a compound extracted and separated from radix acanthopanacis semticosi. The compound involved in the invention has a very obvious hypolipidemic effect on high-fat model rats, can reduce the level of triglyceride in the blood of high-fat model animals, and also has good effects of lowering cholesterol and low-density lipoprotein cholesterol, and raising high-density lipoprotein cholesterol; meanwhile, the biotoxicity of the compound is relatively low. Therefore, the compound involved in the invention is suitable for being used as a hypolipidemic drug.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel hypolipidemic compound extracted from Acanthopanax acanthopanax and a preparation method thereof. Background technique [0002] Dyslipidemia usually refers to elevated plasma cholesterol (TC) and / or triglyceride (TG), commonly known as hyperlipidemia. Hyperlipidemia is the main risk factor for atherosclerosis, and also an important factor for inducing cardiovascular and cerebrovascular diseases. Serum TC, TG and low-density lipoprotein cholesterol (LDL-C) levels increase, and high-density lipoprotein cholesterol (HDL-C) content decreased, can lead to arterial intima damage, increased permeability, accelerated deposition of lipids in the vascular endothelium. When blood lipids rise, a large number of oxygen free radicals are produced, lipid peroxidation is enhanced, and a large amount of MDA is produced, which reduces the activity of SOD and promotes the occurrence and development...

Claims

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Application Information

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IPC IPC(8): C07D317/54A61K31/36A61P9/00A61P9/12A61P9/10A61P3/06
CPCA61P3/06A61P9/00A61P9/10A61P9/12C07D317/54
Inventor 贾东升谢晓亮魏曼温春秀崔施展王腾李茜云田伟
Owner 河北省农林科学院经济作物研究所
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