Application of CD109 as Rheumatoid arthritis (RA) diagnostic marker and therapeutic target

Abstract

The invention belongs to the technical field of clinic medicine, and particularly relates to application of CD109 as a Rheumatoid arthritis (RA) diagnostic marker and a therapeutic target. The invention provides application of CD109 as the RA diagnostic marker and the therapeutic target for preparing an RA diagnostic reagent. CD109 expression and RA correlation are found and disclosed for the first time, it is verified that expression of CD109 in synovial membrane tissue of the RA patient is increased, important basis and method are supplied to clinic diagnosis RA, and it is reminded that CD109 can be adopted as the biologic marker for RA diagnosis. It is further found that a CD109 antibody can restrain RA inflammation, invasion and bone breakage, the morbidity probability and illness degree of collagen-induced arthritis (CIA) mice are remarkably increased, and it is predicted that CD109 can be adopted as a novel target for clinic treatment of RA.

Description

technical field [0001] The invention belongs to the technical field of clinical medicine, and specifically relates to the application of CD109 in the diagnosis and treatment of rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and proliferation of fibroblasts-like synoviocytes (FLS). RA FLS expresses and produces a large number of pro-inflammatory factors and matrix-degrading enzymes, leading to the destruction of joint function and structure. Therefore, identifying the key genes or proteins involved in the pathological changes of RA FLS may provide new therapeutic targets for RA. [0003] At present, the most commonly used clinical method for RA diagnosis is to detect the titer of anti-citrullinated protein antibody (ACPA) in serum by enzyme-linked immunosorbent assay (ELISA). ACPA is a highly specific autoantibody for RA, but only about 60-70% of RA patients are positive, a...

AI Technical Summary

Problems solved by technology

Whether CD109 is involved in the occurrence of other diseases, especially the pathogenesis of RA, is still lack of research

In addition, whether CD109 can be used as a diagnostic marker and therapeutic target for RA has not yet been reported.

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