Anti-chemotherapy brown algae complex tablet for assisting leukocyte growth

A composite sheet and white blood cell technology, which is applied in the direction of non-active ingredients of polymer compounds, antineoplastic drugs, drug combinations, etc., can solve the problem of no relevant research on white blood cells, achieve the effect of improving the effect of white blood cells and reducing the side effects of chemotherapy

Inactive Publication Date: 2019-10-22
QINGDAO KUNBU BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Brown algae extract contains fucoidan sulfate, fucoidan and other active substances, which have extensive research and reports on

Method used

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  • Anti-chemotherapy brown algae complex tablet for assisting leukocyte growth
  • Anti-chemotherapy brown algae complex tablet for assisting leukocyte growth
  • Anti-chemotherapy brown algae complex tablet for assisting leukocyte growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] This embodiment provides an anti-chemotherapy brown algae composite sheet that assists in increasing white blood cells, which is characterized in that it includes the following ingredients in weight percentage: brown algae extract 20%-70%, its sulfate group content 10%-30%, molecular weight 70,000-300,000 Dalton; the remaining materials are auxiliary materials, including shiitake mushroom powder, Agaricus blazei, wolfberry extract, fish collagen oligopeptide.

[0024] The proportion of Lycium barbarum polysaccharide in Lycium barbarum extract is greater than 30%, the content of oligopeptide protein in fish collagen oligopeptide is greater than 65%, and is rich in more than 14 kinds of amino acids.

[0025] The method for preparing brown algae composite sheet comprises the following steps:

[0026] (1) Preparation of edible brown algae extract: The edible brown algae has a wet weight of 1000kg, no need to crush or cut into pieces, put it into a large steamer with seawate...

Embodiment 2

[0028] Embodiment 2 animal experiments

[0029] The applicant studied the treatment and prevention of leukopenia caused by the administration of anticancer drugs with natural plant ingredients without side effects. Using physiological saline, adenine and brown algae compound tablets, the efficacy of anticancer drugs in the prevention and treatment of leukopenia in rabbits was studied. In the experiment, the rabbits were given anticancer drugs (5-FU) to cause advanced leukopenia, and were divided into four groups, which were injected with normal saline, adenine, and brown algae compound tablets to observe the number of peripheral white blood cells and peripheral blood in rabbits. As a result, the following experimental results were obtained.

[0030] 1. Experimental materials and methods

[0031] 1. Experimental Animals

[0032] Mature, white male healthy rabbits weighing approximately 2.5 kg were used. The animals were fed 7 days before the start of the experiment and kept...

Embodiment 3

[0057] Embodiment 3 clinical experiment:

[0058] In order to further verify the effectiveness of the aforementioned formula "Brown Algae Composite Tablet", the applicant entrusted the Hospital of Traditional Chinese Medicine Affiliated to Japan Institute of Oriental Medicine to conduct relevant human experiments. The target of the experiment was 24 people who were taking the anticancer chemotherapy drug 5-FU, and were randomly divided into two groups, with 12 people in each group, see Table 1 for details. The observation group took brown algae compound tablets at the same time, 10 tablets per day. Take two tablets each in the morning, noon and night, and take 4 tablets before going to bed for 14 consecutive days. Two weeks later, the data in Table 2 were obtained through blood collection and counting of white blood cells.

[0059] Experimental equipment and products:

[0060] (1) White blood cell counting equipment MYTHIC220T (J), produced by the French company LUPUS ELECT...

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Abstract

The invention discloses an anti-chemotherapy brown algae complex tablet for assisting leukocyte growth. The anti-chemotherapy brown algae complex tablet is characterized by comprising the following components (by weight): 20-70% of a brown algae extract, the sulfate content of which is 10-30% and molecular weight of which is 70,000-300,000 Daltons; accessories are mushroom powder, Agaricus blazei,a lycium chinese mill extract and fish collagen oligopeptide, which are no more than 1%-20%. The product is synthesized from pure natural food, has no side effect, and has obvious effects of reducingside effects of chemotherapy and improving the leukocyte function of patients after chemotherapy.

Description

technical field [0001] The invention relates to an anti-chemotherapy brown algae compound sheet which assists in increasing white blood cells, and belongs to the field of biotechnology preparation. Background technique [0002] With the deteriorating environment of our country, the incidence of nausea and tumors is also increasing, and has developed into one of the diseases with the highest mortality among urban population. Combination chemotherapy is often used in the treatment of tumors. Combination chemotherapy plays a very important role in inhibiting the spread of tumors. However, due to the slow metabolism and poor selectivity of chemotherapy drugs, it often occurs that although cancer cells are killed while normal cells It has also been damaged, especially for white blood cells. Leukopenia, as the main side effect of combined chemotherapy, has become an important problem that plagues chemotherapy patients. When the leukocytes in the blood continue to be lower than 4....

Claims

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Application Information

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IPC IPC(8): A61K36/03A61K9/20A61K47/46A61K47/42A61P35/00A23L33/105A23L33/18A23L31/00A23P10/28
CPCA23V2002/00A61K9/2063A61K9/2068A61K36/03A23L31/00A23L33/105A23L33/18A23P10/28A61P35/00A23V2200/30A23V2250/21
Inventor 赵英伟赵基恩徐祖洪
Owner QINGDAO KUNBU BIOLOGICAL ENG
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