Magnesium-phosphorus biocompatibility coating to the surface of medical zinc base material and preparation and application of magnesium-phosphorus biocompatibility coating
A biocompatible, zinc-based technology, applied in the field of magnesium-phosphorus biocompatibility coatings, preparation and application, can solve the problems of rough surface morphology, poor biocompatibility of zinc hydroxide, vascular calcification, etc. Improve biocompatibility, good clinical application prospects, and reduce the effect of initial release
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Embodiment 1
[0037] A magnesium-phosphorus biocompatible coating was prepared on the surface of an extruded Zn-3wt%Cu (Zn-Cu system) alloy material. Specific steps are as follows:
[0038] 1) First, the extruded Zn-3wt% Cu alloy was made into a Φ10×3mm sample, which was polished with 320# and 1200# water sandpaper in sequence, and then ultrasonically cleaned with absolute ethanol, acetone, and absolute ethanol, respectively. 10min, blow dry, and then process the front and back sides of the sample with a UV-ozone cleaner for 10min each.
[0039] 2) Configure phosphate reaction solution: take MgSO 4 :NaH 2 PO 4 =1:1.5 (substance ratio, 0.2mol / L, 0.3mol / L respectively), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=4.0.
[0040] 3) Put the treated Zn-3Cu alloy sample into the above-mentioned phosphate reaction solution and let it soak for 6 hours at room temperature (25° C.).
[0041] SEM (such as figure 1 Shown) shows that the surface of the coating has a ...
Embodiment 2
[0043] Preparation of magnesium-phosphorus biocompatible coating on the surface of Zn-Mg alloy porous bone tissue engineering scaffold for tissue engineering. Specific steps are as follows:
[0044] 1) First, the Zn-Mg alloy porous bone tissue engineering scaffold for tissue engineering is made into a Φ10×3mm sample, and the porous surface is polished by electrolytic polishing process in turn, and ultrasonically cleaned with absolute ethanol, acetone, and absolute ethanol for 10 minutes each , blow dry, and then treat the sample with a UV-ozone cleaner for 10 minutes.
[0045] 2) Configure phosphate reaction solution: take MgSO 4 :NaH 2 PO 4 =1:1.5 (substance ratio, 0.2mol / L, 0.3mol / L respectively), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=5.0.
[0046] 3) Put the processed Zn-Mg alloy porous bone tissue engineering scaffold sample into the above-mentioned phosphate reaction solution and let it soak for 12 hours at a constant temperature ...
Embodiment 3
[0049] Preparation of magnesium-phosphorus biocompatible coating on the surface of cardiovascular stent processed by Zn-Mn alloy. Specific steps are as follows:
[0050] 1) Firstly, the Zn-Mn alloy is made into a Φ3×15mm sample, and the surface is polished successively by electrolytic polishing, and the anhydrous ethanol, acetone, and anhydrous ethanol are respectively ultrasonically cleaned for 10 minutes, dried, and then treated with an ultraviolet ozone cleaner Sample 10min.
[0051] 2) Configure phosphate reaction solution: take MgSO 4 :NaH 2 PO 4 =1:1.5 (substance ratio, respectively 0.3mol / L, 0.45mol / L), add deionized water to dissolve, then add 1mol / L NaOH solution to adjust pH=4.0.
[0052] 3) Put the treated Zn-Mn alloy stent sample into the above-mentioned phosphate reaction solution and let it soak for 1 hour at room temperature (25° C.).
[0053] The scanning electron microscope observed that the thickness of the magnesium-phosphorus coating was ~1.5 μm, the a...
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