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Mass spectrometry with increased duty cycle

A technology of mass spectrometry analysis and mass-to-charge ratio, which is applied in the field of mass spectrometer and can solve problems such as low duty cycle

Active Publication Date: 2022-07-22
MICROMASS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, in these techniques only a relatively small fraction of the entire mass-to-charge ratio range is transmitted by the mass filter (or ejected from the ion trap) at any time, so the duty cycle of this technique is very low

Method used

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  • Mass spectrometry with increased duty cycle
  • Mass spectrometry with increased duty cycle
  • Mass spectrometry with increased duty cycle

Examples

Experimental program
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Embodiment Construction

[0131] figure 1 A block diagram of a known instrument is shown, including an ion source 12 , a quadrupole mass filter 14 , a fragmentation or reaction cell 16 , and an orthogonal acceleration time-of-flight mass analyzer 18 .

[0132] In operation, ions are generated by ion source 12 and delivered to quadrupole mass filter 14 . A voltage is applied to the quadrupole mass filter 14 so that it can only transmit ions within a certain mass-to-charge ratio transmission window. Ions with mass-to-charge ratios outside this window are filtered out and not transmitted by mass filter 14 . Thus, the mass-to-charge ratio of the precursor ions transmitted by the mass filter is known. These ions then enter the fragmentation or reaction cell 16 and are fragmented or reacted with other ions or molecules therein to produce product ions. These product ions are forwarded to the time-of-flight mass analyzer 18, where they are mass-analyzed. Thus, the product ions detected by the time-of-fligh...

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Abstract

A method of mass spectrometry is disclosed, comprising: applying a voltage to a mass filter or ion trap so that it can transmit or eject ions having a mass-to-charge ratio in a separate first mass-to-charge ratio window and a second mass-to-charge ratio window. within a charge ratio window; varying the voltage over time such that the first window and the second window simultaneously move through different mass-to-charge ratio ranges; detecting ions transmitted or ejected in the windows or ions derived therefrom; and deconvolving the resulting ion signal, wherein the deconvolution includes: a) modeling the ion signal expected to be detected at the detector; b) correlating the model signal with the ion signal from the detector making a comparison; and c) determining whether the model signal matches the ion signal from the detector.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to and the benefit of UK Patent Application No. 1706011.2 filed on 13 April 2017. The entire contents of this application are incorporated herein by reference. technical field [0003] The present invention relates generally to mass spectrometers, and more particularly, to spectrometers in which ions are selectively transported or ejected downstream through a mass filter or ion trap. Background technique [0004] It is known that by scanning the range of mass-to-charge ratios transmitted by the quadrupole mass filter (or scanning the range of mass-to-charge ratios ejected from the analytical ion trap) in mass-to-charge ratio analytical mode, segmenting the ions and recording mass-to-flight data during the scan time to perform data-independent parallel MSMS experiments. For example, US 2015 / 0136969 discloses such a method. Such methods generate a two-dimensional data set that can be in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/42
CPCH01J49/427H01J49/0027
Inventor 马丁·雷蒙德·格林詹森·李·维尔德古斯基思·理查森
Owner MICROMASS UK LTD