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A kind of non-oxidative ti with the function of selectively killing cancer cells 3 c 2 Quantum dots and their preparation methods and applications

A technology of quantum dots and cancer cells, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, titanium carbide, etc., can solve the problems that have not been reported in the preparation, and achieve the purpose of inhibiting and killing cancer cells. Water dispersion characteristics, the effect of simple and convenient preparation method

Active Publication Date: 2022-08-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ti involved in the above patent documents 3 C 2 Quantum dots will inevitably cause Ti 3 C 2 Oxidation of quantum dots
[0005] Currently, completely oxide-free Ti 3 C 2 The preparation of quantum dots has never been reported, and the prepared oxide-free Ti 3 C 2 Quantum dots have the property of selectively inhibiting and killing cancer cells

Method used

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  • A kind of non-oxidative ti with the function of selectively killing cancer cells  <sub>3</sub> c  <sub>2</sub> Quantum dots and their preparation methods and applications
  • A kind of non-oxidative ti with the function of selectively killing cancer cells  <sub>3</sub> c  <sub>2</sub> Quantum dots and their preparation methods and applications
  • A kind of non-oxidative ti with the function of selectively killing cancer cells  <sub>3</sub> c  <sub>2</sub> Quantum dots and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, raw material Ti 3 C 2 Preparation of (MXene)

[0048] First, add Ti to a teflon beaker 3 AlC 2 (MAX phase) 10 parts, and then slowly add 90 parts of hydrofluoric acid in small amounts and several times. After adding, keep stirring for 3 days at an ambient temperature of 30° C. until the complete reaction is complete. Then, centrifugation and multiple water washes were performed until the pH value was close to 7. Then vacuum-drying to obtain black Ti 3 C 2 Base powder.

[0049] Test the Ti obtained in this example 3 C 2 SEM images of substrates, such as figure 2 shown. Depend on figure 2 It can be seen that Ti 3 C 2 The substrate size is in the micrometer scale.

Embodiment 2

[0050] Embodiment 2, "micro-explosive" method prepares Ti 3 C 2 quantum dots

[0051] Put 10 parts of two-dimensional material Ti 3 C 2 Place in a Teflon beaker, pour 50 parts of liquid nitrogen into the beaker and keep at room temperature for 3 minutes. During this process, liquid nitrogen will intercalate the Ti 3 C 2 and with constant evaporation. When the remaining amount of liquid nitrogen in the beaker is very small, quickly add 50 parts of deionized water at 100°C. Since the boiling point of liquid nitrogen is -196°C, extreme temperature differences occur, resulting in 3 C 2 The liquid nitrogen in the interlayer will be rapidly vaporized, and a large amount of deionized water will form a water seal effect, making the Ti 3 C 2 The microscopic accordion-like structure formed a closed space, which in turn caused a "micro-explosion" to obtain an aqueous suspension. The entire process above only takes a few minutes. (Note: If the residual amount of liquid nitroge...

Embodiment 3

[0057] Embodiment 3, "micro-explosive" method prepares Ti 3 C 2 quantum dots

[0058] 20 copies of two-dimensional material Ti 3 C 2 Place in a Teflon beaker, pour 50 parts of liquid nitrogen into the beaker and keep at room temperature for 2 minutes. During this process, liquid nitrogen will intercalate the Ti 3 C 2 and with constant evaporation. When the remaining amount of liquid nitrogen in the beaker is small, quickly add 50 parts of deionized water at 90°C. Since the boiling point of liquid nitrogen is -196°C, extreme temperature differences occur, resulting in 3 C 2 The liquid nitrogen in the interlayer will be rapidly vaporized, and a large amount of deionized water will form a water seal effect, making the Ti 3 C 2 The microscopic accordion-like structure formed a closed space, which in turn caused a "micro-explosion" to obtain an aqueous suspension. The entire process above only takes a few minutes. (Note: If the residual amount of liquid nitrogen is 0, n...

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Abstract

The present invention relates to a kind of non-oxidized Ti with the function of selectively killing cancer cells 3 C 2 Quantum dots, preparation method and application thereof, the average size of the quantum dots is only about 7nm, completely free of oxidation, and without any toxic elements such as heavy metals, the quantum dots have broad-spectrum inhibition and killing effects on cancer cells, and It exhibits excellent biocompatibility and extremely low cytotoxicity to human normal stem cells. The non-oxidized Ti of the present invention 3 C 2 Quantum dots have great application potential on the road to fight and defeat cancer in the future. At the same time, the quantum dots have fast and spontaneous water dispersion properties. When preparing its aqueous dispersion, it does not need any ultrasonic and stirring treatment, which is very beneficial to the direct application in biology or medicine.

Description

technical field [0001] The present invention relates to a kind of Ti which is obtained by a new "micro-explosion" method without toxic elements and without oxidation 3 C 2 Quantum dots have the functions of inhibiting and killing cancer cells on the basis of showing good biocompatibility to normal human stem cells, and belong to the field of nanotechnology. Background technique [0002] Cancer is a stubborn disease that has not yet been conquered by human beings, and its incidence is getting higher and higher, becoming a potential threat to people's life safety. As we all know, among the four major therapies of tumor surgery, radiotherapy, chemotherapy and biological therapy, chemotherapy is still the main treatment method, but the existing chemotherapeutic drugs have limited anti-tumor activity, show extremely serious side effects, and are expensive. Therefore, it is of great significance to explore drugs with no toxic side effects and good anti-tumor effect, which has al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B32/921B82Y40/00A61K41/00A61P35/00
CPCC01B32/921B82Y40/00A61K41/0057A61P35/00C01P2004/64C01P2004/24
Inventor 陶绪堂李雪松
Owner SHANDONG UNIV