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Calcium sulfate bone cement containing bioglass and preparation method thereof

A technology of bioglass and calcium sulfate, which is applied in the field of biomedical materials, can solve the problems that bioglass cannot realize minimally invasive injection, cannot provide mechanical support, and the degradation time is too fast, and achieve excellent biocompatibility and osteogenic performance , excellent compressive strength, and the effect of delaying the degradation rate

Inactive Publication Date: 2020-02-07
湖北联结生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, calcium sulfate bone cement also has disadvantages such as short injectable time and fast degradation time.
[0003] Bioglass has good bioactivity and biocompatibility, can provide calcium ions and phosphate ions needed for human osteogenesis, and has good osteogenesis performance; however, pure bioglass cannot achieve minimally invasive injection, and cannot Capable of self-curing, unable to provide certain mechanical support at the initial stage of implantation
[0004] Due to the defects of its own material, the artificial bone prepared from a single material is often difficult to meet various requirements.

Method used

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  • Calcium sulfate bone cement containing bioglass and preparation method thereof
  • Calcium sulfate bone cement containing bioglass and preparation method thereof
  • Calcium sulfate bone cement containing bioglass and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A calcium sulfate bone cement (injection type) containing bioglass, prepared by the following method:

[0031] Prepare a sodium citrate and 2% magnesium sulfate solution with a mass concentration of 0.1%, add calcium sulfate dihydrate to the solution with a mass percentage of 20%, stir for 4 hours, filter, put it in a filter bag, and put it in a high-temperature and high-pressure device (Materials are not in contact with the water in the device), treated at 130°C for 6 hours, after treatment, put the materials in an environment of 110°C and dried for 3 hours, crushed, ground, and sieved the obtained materials to obtain α-calcium sulfate hemihydrate .

[0032] Mix 75 parts of α-calcium sulfate hemihydrate, 22 parts of bioglass, 2 parts of hypromellose, and 1 part of calcium chloride through mechanical grinding to make the powder evenly mixed, and then add water for injection according to the solid-to-liquid ratio of 1:0.4, Stir it into a slurry, then transfer it to a sy...

Embodiment 2

[0034] A calcium sulfate bone cement (injection type) containing bioglass, prepared by the following method: 55 parts of α-calcium sulfate hemihydrate prepared in Example 1, 5 parts of calcium sulfate dihydrate, 38 parts of bioglass, carboxymethyl 1.9 parts of sodium cellulose and 0.1 part of strontium chloride, the powder is mixed uniformly by mechanical grinding, then water for injection is added according to the solid-to-liquid ratio of 1:0.4, stirred into a slurry, then transferred to a syringe, and injected into normal saline , without collapsing for three days, the injection time is 11 minutes, injected into the mold, and then placed in a constant temperature and humidity box (temperature 37°C, humidity 98%) to cure and form. After curing for 3 days, the compressive strength is 11MPa.

Embodiment 3

[0036] A calcium sulfate bone cement (injection type) containing bioglass, prepared by the following method: 70 parts of α-calcium sulfate hemihydrate prepared in Example 1, 28 parts of bioglass, 1.5 parts of chitosan, 0.5 parts of magnesium sulfate Mix the powder evenly by mechanical grinding, then add physiological saline according to the solid-liquid ratio of 1:0.4, stir it into a slurry, then transfer it to a syringe, inject it into physiological saline, it will not collapse for three days, and the injectable time is 18 minutes , injected into the mold, and then placed in a constant temperature and humidity box (temperature 37°C, humidity 98%) for curing and molding. After curing for 3 days, the compressive strength is 16MPa.

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to calcium sulfate bone cement containing bioglass and a preparation method of the calcium sulfate bone cement. Thecalcium sulfate bone cement containing the bioglass is prepared from powder and curing liquid according to a ratio of 1: 0.3-0.8. The powder comprises the following components in percentage by mass:50%-85% of calcium sulfate, 10%-45% of bioglass, 1%-5% of an organic additive and 0.1%-3% of an inorganic additive, and the powder is prepared by grinding and mixing the components. The bone cement disclosed by the invention has excellent biocompatibility; different dosage forms can be prepared through the liquid-solid ratio according to the osteogenesis performance and the compressive strength, the injection type can be used for minimally invasive surgery, the muddy products can be shaped at will, various requirements of patients can be met, and bone cement products with different degradationspeeds can be prepared according to different bone defect sizes and bone defect areas by adjusting the component proportion.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to calcium sulfate bone cement containing bioglass and a preparation method thereof. Background technique [0002] As a traditional bone repair material, calcium sulfate has good biocompatibility and osteoconductivity, and has achieved excellent clinical results. For example, Osteoset, the first-generation bone graft substitute product developed by Wright Company in the United States, has a highly consistent crystal structure and a stable absorption rate after implantation; and the subsequent development and production of injectable bone cement (MIIG), which overcomes the need for Osteoset to be preformed. , can not completely fill the bone defect cavity, and is also suitable for minimally invasive surgery, reducing the pain of patients. The preformed product Stimulan and the injectable product Genex developed by the British company Biocomposites, whose main component is also hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/02A61L27/20A61L27/50A61L27/58
CPCA61L27/025A61L27/10A61L27/20A61L27/50A61L27/58A61L2400/06A61L2430/02C08L5/04C08L5/08C08L1/284C08L1/286
Inventor 张旗张铁代春初司旭祝超胡丽叶莹
Owner 湖北联结生物材料有限公司
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