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Layer lubricating catheter and preparation method thereof

A lubricating catheter and layered technology, applied in the field of layered lubricating catheter and its preparation, can solve the problems of high cost, unfavorable human body, cumbersome technology, etc., and achieve the effects of low cost, easy large-scale production, and simple operation

Active Publication Date: 2020-02-28
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the technique of preparing water-lubricated catheters by modifying the body catheters with traditional hydrophilic lubricating coatings is cumbersome.
First of all, it is necessary to prepare the body catheter, and then apply a hydrophilic lubricating coating on its surface by photocuring or thermal curing, which is costly; moreover, the bonding force between the coating and the substrate needs to be considered; in addition, in the chemical industry Most of the coatings used contain various additives, which are harmful to the human body

Method used

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  • Layer lubricating catheter and preparation method thereof
  • Layer lubricating catheter and preparation method thereof
  • Layer lubricating catheter and preparation method thereof

Examples

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preparation example Construction

[0026] The invention provides a method for preparing a layered lubricating catheter, comprising the following steps:

[0027] (1) Provide a hollow hydrogel tube;

[0028] (2) immersing the hollow hydrogel tube in a swelling solution for swelling treatment, and then immersing the swollen hollow hydrogel tube in water for stabilization treatment to obtain a layered lubricating catheter.

[0029] The present invention firstly provides hollow hydrogel tubes. In the present invention, the preparation method of the hollow hydrogel tube preferably includes the following steps:

[0030] (a) iron wire is immersed in the hydrochloric acid solution and carries out surface activation;

[0031] (b) immersing the surface-activated iron wire in the monomer reaction solution for polymerization reaction, and growing a hydrogel layer on the surface of the iron wire;

[0032] (c) Submerging the iron wire with the hydrogel layer grown in the ferric ion aqueous solution for immersion, and then ...

Embodiment 1

[0042] (1) Immerse the iron wire in 0.1mol / L HCl aqueous solution for 60s to activate the surface; weigh 0.32g of acrylic acid, 5.41g of acrylamide, 0.03g of potassium persulfate and 0.01g of N,N'-methylenebis Add acrylamide to 50mL water to prepare a monomer reaction solution; immerse the activated iron wire in the above monomer reaction solution and react at 20°C for 10 minutes, and a hydrogel layer grows on the surface of the iron wire; The iron wire is immersed in 0.1mol / L ferric ion aqueous solution for 48 hours, and then the iron wire is removed to obtain a high-strength hollow hydrogel tube.

[0043] (2) Submerge the hollow hydrogel tube prepared in step (1) into a 0.5 mol / L aqueous solution of citric acid for 180 seconds to perform dynamic dissociation of the surface gel network, and then take it out and put it into deionized water for 24 hours. A hydrogel lubricated catheter with lubricated inner and outer surfaces can be obtained.

[0044] The cross-sectional microg...

Embodiment 2

[0049] Other conditions are the same as in Example 1, only the aqueous solution of citric acid is replaced by sodium hydroxide solution.

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Abstract

The invention relates to the technical field of biomedical materials, and provides a layer lubricating catheter and a preparation method thereof. A hollow hydrogel tube is soaked in a swelling liquidfor swelling treatment, and then the hollow hydrogel tube is soaked in water for stabilization treatment after swelling treatment to obtain a layered lubricating catheter. The layer lubricating catheter is entirely composed of a hydrogel material, namely, both a lubricating layer and a supporting layer both are made of the hydrogel material, the lubricating layer and the supporting layer are bonded together by covalent bonds, so that the stability is strong, and the catheter belongs to a novel water lubricating catheter material. The prepared catheter can be lubricated on inner surface, outersurface or both inner and outer surface, and has an important application prospect in the field of biomedical instruments.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a layered lubricating catheter and a preparation method thereof. Background technique [0002] Lubricity is one of the important performance indicators of interventional catheters. For example, endowing the surface of the urinary catheter or sputum suction tube with excellent hydrophilic lubricating properties can reduce the friction between the soft tissue and the surface of the device, greatly reducing the patient's treatment pain; endowing the surface of the intravascular interventional catheter with excellent water lubricating properties can reduce Catheter damage to the vessel wall, to avoid the occurrence of coagulation reaction. Therefore, the development of new water-lubricated medical catheters has important application value. [0003] At present, interventional catheters used clinically include polyurethane, polyethylene, polyvinyl chloride, rubber and si...

Claims

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Application Information

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IPC IPC(8): A61M25/00A61L29/14A61L29/08
CPCA61L29/08A61L29/145A61L2400/18A61L2420/02A61L2420/08A61M25/0045A61M2025/0047
Inventor 周峰麻拴红马正峰
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI