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Personal care compositions comprising zinc:usnic acid complexes and methods of use

A personal care and composition technology, applied in the direction of washing composition containing organic compounds, drug combination, detergent composition, etc., can solve the problems that cannot fully solve the problems of water solubility and efficacy attributes

Active Publication Date: 2020-03-06
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Current antimicrobial products do not adequately address water solubility and efficacy attributes

Method used

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  • Personal care compositions comprising zinc:usnic acid complexes and methods of use
  • Personal care compositions comprising zinc:usnic acid complexes and methods of use
  • Personal care compositions comprising zinc:usnic acid complexes and methods of use

Examples

Experimental program
Comparison scheme
Effect test

example 4

[0089] Example 4 - Solubility Determination

[0090] Solubility determination of the Zn: lichenate complex was performed using standard techniques. The solubility of lichenic acid in deionized water at 35°C was reported to be 6.3 ppm (see Jin et al., Solubility of(+)-Usnic Acid in Water, Ethanol, Acetone, Ethyl Acetate and n-Hexane, J Solution Chem., 2013, 42:1018-1027). The Zn: lichenate complex showed a solubility of 13.5 ppm in deionized water at room temperature.

example 5

[0091] Example 5 - In Vitro Cup Scrub AB Test of Soap Bars

[0092] This assay measures residual antimicrobial efficacy. 1% of Zn: lichenate complex was added to alkaline soap flakes and processed into soap bars. Wet the strip sample and rub it against the pigskin. The pigskin is then rinsed, slightly dried and inoculated with Staphylococcus aureus. After incubation, recovered bacteria were collected using the cup scrubbing technique and counted using standard plate counting procedures. Average log counts of colony forming units (CFU) were calculated for replicate samples. As a placebo, alkaline soap flakes were processed into thin bars. As a positive control, will also have sodium palmitate, sodium oleate, sodium laureth (sodium soap), water, glycerin, talc, PEG-12, fragrance, sodium chloride, triclocarban, citric acid, A soap formulation of titanium dioxide, pentasodium pentetate, etidronate, yellow 10, orange 4 and also containing 0.4% triclocarban (TCC) was processed in...

example 6

[0095] Example 6-Minimum Inhibitory Concentration Determination

[0096] The minimum inhibitory concentration (MIC) is the lowest concentration of antimicrobial that inhibits the visible growth of microorganisms after overnight incubation. Determination of MIC values ​​of zinc: lichenate complex and lichenic acid against Staphylococcus aureus and Escherichia coli by broth microdilution method. Briefly, 0.1% stock solutions were prepared in dimethylsulfoxide (DMSO). Using a 96-well microtiter plate, the corresponding test concentrations were 500, 250, 125, 62, 31, 16, 8, 4, 2, 1, 0.5 and 0.2 ppm. The level of bacterial growth was assessed using the optical density reading at 610 nm for each well. MIC results are listed in Table 2.

[0097] Table 2: MIC determination results

[0098]

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PUM

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Abstract

Disclosed herein are personal care compositions comprising Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided. The personal care compositions may include a cleansing component and an antibacterial component, wherein the antibacterial component comprises Zn:usnate complexes having a 1:2 zinc to usnate molar ratio.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 534,420, filed July 19, 2017, which is incorporated herein by reference. technical field [0003] The present invention relates to personal care compositions comprising zinc: lichenate complexes and methods of using and making these compositions. Background technique [0004] Many human diseases arise from pathogenic microorganisms, which include bacteria, viruses and fungi. The presence of such pathogenic microorganisms can lead to sepsis, serious infections of the upper and lower respiratory tracts, serious infections of the central nervous system, meningitis, serious infections of the intra-abdominal tissues including the peritoneum, genitourinary tract, skin and soft tissues, and Various other infections such as systemic mycoses, candidiasis, including those caused by dermatophytes. Significant progress has been made over the past 100...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/27A61K8/49A61Q11/00C07D307/91A61P1/02A61P31/02A61Q17/00
CPCA61K8/27A61K8/4973A61Q15/00A61Q17/005A61Q19/00A61Q19/10C11D9/26A61K2800/58A61P31/02C11D3/48C11D17/02C11D17/08Y02A50/30A61K8/49A61P1/02A61Q11/00A61Q17/00A61K8/42A61K8/44
Inventor 斯坦尼斯拉夫·亚拉茨潘龙卡尔西克·桑班塔穆尔蒂毛军红范爱星
Owner COLGATE PALMOLIVE CO