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A kind of etomidate nano preparation and preparation method thereof

A technology of etomidate and nanoliposomes, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of unusable and unfavorable preservation of nutrients, and achieve easy storage, non-irritating allergies, and biocompatibility good sex effect

Active Publication Date: 2022-02-08
SOUTHWEST MEDICAL UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported that propylene glycol can cause side effects such as acidosis, coma, seizures, hyperosmolarity, and arrhythmia; etomidate fat emulsion cannot be used in patients who are allergic to soybeans, and caution should also be used in obese or hyperlipidemia patients. And due to the presence of nutrients, it is not conducive to preservation
[0004] Therefore, develop a kind of novel etomidate preparation, the side effect that promotes drug minimizes and avoids the problem of existing preparation, still is a big challenge to etomidate clinical application

Method used

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  • A kind of etomidate nano preparation and preparation method thereof
  • A kind of etomidate nano preparation and preparation method thereof
  • A kind of etomidate nano preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1 etomidate nano-preparation of the present invention

[0033] (1) Weigh 100mg of lecithin and 10mg of etomidate and put them in two 3ml test tubes, numbered a and b.

[0034] (2) Add 1ml of chloroform to the test tubes a and b respectively, shake well, and shake well until there are no solid particles left on the tube wall.

[0035] (3) Pour all the solutions in 2 test tubes a and b into a rotary evaporator at 25° C., keep a constant speed of 60 r / min, remove volatile solvents, and make the liposomes form a lipid dry film on the wall of the spherical device.

[0036] (4) After the thin film is formed, continue to flow nitrogen gas for 10 minutes to remove the residual volatile organic solvent.

[0037] (5) Add 5ml of phosphate buffer solution (PBS) with a pH value of 7.35, shake and shake well until there are no residual solid particles on the tube wall. After being completely dissolved, a phosphate buffer solution with a concentration of 2 mg etomidate pe...

Embodiment 2

[0039] Embodiment 2 etomidate nano-preparation of the present invention

[0040] (1) Weigh 90mg of lecithin, 10mg of pluronic P123, and 10mg of etomidate, and place them in three 3ml test tubes, numbered a, b, and c.

[0041] (2) Add 1ml of chloroform to the test tubes a, b, and c respectively, shake well, and shake well until there are no solid particles left on the tube wall.

[0042] (3) Pour all the solutions in the 3 test tubes a, b, and c into a rotary evaporator, keep a constant speed of 60r / min at 25°C, remove the volatile solvent, and make the liposomes form a lipid dry film on the wall of the spherical device.

[0043] (4) After the thin film is formed, continue to flow nitrogen gas for 10 minutes to remove the residual volatile organic solvent.

[0044] (5) Add 5ml of phosphate buffer solution (PBS) with a pH value of 7.35, shake and shake well until there are no solid particles remaining on the tube wall. After it is completely dissolved, a phosphate buffer solut...

Embodiment 3

[0046] Embodiment 3 etomidate nano-preparation of the present invention

[0047] (1) Weigh 80mg of lecithin, 20mg of Pluronic P123, and 10mg of etomidate in three 3ml test tubes, numbered a, b, c

[0048] (2) Add 1ml of chloroform to the test tubes a, b, and c respectively, shake well, and shake well until there are no solid particles left on the tube wall.

[0049] (3) Pour all the solutions in the 3 test tubes a, b, and c into a rotary evaporator, keep a constant speed of 60r / min at 25°C, remove the volatile solvent, and make the liposomes form a lipid dry film on the wall of the spherical device.

[0050] (4) After the thin film is formed, continue to flow nitrogen gas for 10 minutes to remove the residual volatile organic solvent.

[0051] (5) Add 5ml of phosphate buffer solution (PBS) with a pH value of 7.35, shake and shake well until there are no residual solid particles on the tube wall. After it is completely dissolved, a phosphate buffer solution with a concentrati...

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Abstract

The invention provides an etomidate nano preparation, which is prepared from the following raw materials in parts by weight: 10 parts of etomidate, 0-30 parts of pluronic and 70-100 parts of lecithin. The nano-preparation of the present invention has multiple advantages of high safety, low toxicity, non-irritating allergy, good biocompatibility, good bioavailability and high stability, and has the value of practical application and popularization.

Description

technical field [0001] The invention relates to an etomidate nano preparation and a preparation method thereof. Background technique [0002] Liposome, also known as liposome, is a new type of drug carrier with targeted drug delivery function, which has a phospholipid bilayer structure similar to the cell membrane of organisms (including human body). In recent decades, it has been mainly used to develop new drugs, especially targeted chemotherapy drugs. Preparations such as liposomes and polymer micelles based on hydrophilic nanocarriers have been actively researched to improve the water solubility of hydrophobic drugs, achieve selective drug biodistribution and control drug release, thereby improving efficacy and reducing drug side effects , but there is no liposome as a carrier for the preparation of etomidate. [0003] Etomidate is a non-barbiturate intravenous anesthetic. It is a white crystal or crystalline powder. It mainly acts on the sensory center of the high spin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/24A61K47/10A61K31/4174A61P23/00B82Y5/00
CPCA61K9/127A61K47/24A61K47/10A61K31/4174A61P23/00B82Y5/00
Inventor 刘浩张羽寒王斯娇袁行陈晶晶石心雨
Owner SOUTHWEST MEDICAL UNIVERISTY