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Traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation and application of traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation

An anti-inflammatory effect and extract technology, applied in anti-inflammatory agents, drug combinations, medical preparations containing active ingredients, etc., can solve problems not related to the use of angelica and Chuanxiong medicine, achieve good protection and reduce oxidation stress Stimulate and reduce the effect of lipid peroxidation

Pending Publication Date: 2020-04-03
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor of the present invention [(Discussion on the anti-inflammatory mechanism of cyclooxygenase (COX-2) inhibitors to improve cardiovascular safety [J]. Chinese Journal of Traditional Chinese Medicine, 2014,39(20):4054-4059.] has discussed Cyclooxygenase (COX-2) inhibitors improve the anti-inflammatory mechanism of cardiovascular safety, mentioning that anti-inflammatory drugs can improve the antioxidant effect is beneficial to reduce cardiovascular risk, but none of them involve the use of Angelica and Chuanxiong

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  • Traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation and application of traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment one: medicine preparation method.

[0035] Take 200g of angelica medicinal material and 100g of Chuanxiong medicinal material, crush them into coarse powder, soak in distilled water 20 times the weight of the medicinal materials for 1 hour, then reflux extraction for 1 hour, filter, and then reflux the filter residue with 20 times the weight of industrial ethanol (95% ethanol) for 1 hours, the two filtrates were combined, concentrated to a paste, and dried to prepare the extracts of angelica and chuanxiong.

[0036] Take 2000g of angelica medicinal material and 1000g of Chuanxiong medicinal material, grind them into coarse powder, soak them in 50% ethanol which is 10 times the weight of the medicinal materials for 1 hour, then reflux extraction for 1 hour, filter, and filter the residue with 10 times the weight of 50% ethanol for 1 hour, The two filtrates are combined, concentrated to a paste, and dried to prepare the extracts of Angelica sinensis and Rhizoma...

Embodiment 2

[0049] Embodiment two: the preparation and application of Chinese medicine extract.

[0050] Crush Angelica and Rhizoma Chuanxiong, mix them at a weight ratio of 1:0, 1:1, 1:2, 2:1, 1:1.5, and 0:1, weigh 4.5 g of medicinal material powder, put them into a round bottom flask, and distilled water For solvent extraction. Add 150 mL of distilled water to the medicinal material powder, weigh and record, heat and reflux for 1 h, let cool, make up for the weight loss of the solvent, mix well, filter with suction, add 150 mL of distilled water to the filter residue, weigh, heat and reflux for 1 h, cool, make up for the weight loss of the solvent, and combine Two filtrates were obtained to obtain water extracts of Angelica sinensis and Rhizoma Chuanxiong in different ratios, concentrated and dried to obtain extracts of Angelica sinensis and Rhizoma Chuanxiong.

[0051] The extraction solvents were prepared with 95% ethanol, 50% ethanol, water first and then alcohol (the alcohol in thi...

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Abstract

The invention discloses a traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation. The traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation is prepared from raw materials of radix angelicae sinensis and rhizoma ligustici wallichii, wherein the weight ratio of the radix angelicae sinensisto the rhizoma ligustici wallichii is (1-10) to (1-10). The traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation is prepared by the following method including the steps of firstly, performing water extraction on the radix angelicae sinensis and the rhizoma ligustici wallichii and then performing alcohol extraction, or firstly performing alcohol extraction and then performing water extraction, or performing water-alcohol combined solvent extraction. According to the traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation disclosed by the invention, the radix angelicae sinensis and the rhizoma ligustici wallichii are in compatibility, and water-alcohol combined solvent extraction isperformed, so that synergistic dissolving out of multiple components is facilitated, and the pharmacology effects also have synergistic effects. The traditional Chinese medicine extract disclosed bythe invention has the efficacy of promoting blood circulation, promoting the circulation of qi, activating meridians to stop pain, reducing swelling and removing blood stasis, and has the effects of resisting inflammation and alleviating pain; and through reducing oxidation resisting damage, the traditional Chinese medicine extract having effects of promoting blood circulation and resisting inflammation has good protecting effects on the cardiovascular system, can prevent and treat symptoms pertinent to inflammation and pain, and can be used for preparing medicines for preventing or / and treating the symptoms pertinent to the inflammation and the pain.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract with blood-activating and anti-inflammatory effects and an application thereof, belonging to the technical field of traditional Chinese medicine extraction. Background technique [0002] Angelica sinensis is the dried root of the Umbelliferae plant Angelica sinensis. It is warm in nature, pungent and sweet in taste, and returns to the liver, heart and spleen meridian. Ligusticum chuanxiong is the dried rhizome of Ligusticumchuanxiong Hort, a plant in the family Umbelliferae. It is warm in nature and pungent in taste. Angelica and Chuanxiong herbs are often used in combination for nourishing blood and promoting blood circulation, regulating menstruation and relieving pain. They are used in traditional Chinese medicine prescriptions and Chinese medicine compound prescriptions in different proportions, such as bergamot powder, Siwu decoction, Bazhen decoction and Danggui Shaoyao powder. Amon...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61P29/00A61P9/00
CPCA61K36/232A61K36/236A61K2236/331A61K2236/333A61K2236/39A61P9/00A61P29/00A61K2300/00
Inventor 毛近隆高世杰耿炜唐迎雪王婕张欣欣管西芹
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE