Unmanned isolation detection system and method for high-risk pathogenic microorganisms

Abstract

The invention belongs to the field of biosafety protection technologies and equipment, and discloses an unmanned isolation detection system and method for high-risk pathogenic microorganisms. The device comprises an isolation cabin, a transfer cabin, a pathogen nucleic acid automatic processing and detecting unit, a ventilation filtering system and a control system; the pathogen nucleic acid automatic processing and detecting unit is arranged in the isolation cabin, a waste discharge port is formed in the bottom of the isolation cabin, operation gloves are arranged in the isolation cabin, oneside is communicated with the transfer cabin, and an equipment door is arranged on the other side; one side of the transfer cabin is communicated with the isolation cabin, a first airtight door is arranged on the other side of the transfer cabin, and a second airtight door is arranged on the transfer cabin and communicated with a sample inactivation module; the ventilation filtering system comprises an isolation cabin ventilation filtering device and a transfer cabin ventilation filtering device; the isolation cabin ventilation filtering device is arranged at the top of the isolation cabin, and the transfer cabin ventilation filtering device is arranged on a window body of the transfer cabin. The device disclosed by the invention is high in automation degree and has good biological safety.

Description

technical field [0001] The invention relates to the field of biological safety protection technology and equipment, in particular to an unmanned isolation detection system and method for high-risk pathogenic microorganisms. Background technique [0002] In recent years, major infectious diseases caused by high-risk pathogenic microorganisms have come on fiercely, causing serious harm to human health. In order to reduce the risk of infection, the processing and testing of samples that may contain high-risk pathogenic microorganisms usually need to be carried out in a biosafety cabinet in a high-level biosafety laboratory, and operators must wear personal protective equipment throughout the process. Nevertheless, for the operator, there is still a relatively large exposure risk in the whole working process. [0003] my country has a vast territory, and the number of high-level biosafety laboratories is unevenly distributed, especially in remote areas, which are the natural or...

AI Technical Summary

Problems solved by technology

Although there are multi-type liquid workstations on the market that can automatically extract nucleic acids, they are generally used in experimental occasions where a single type of specimen is extracted and the amount of specimens is very large (dozens to hundreds) at a time, and the extraction process is free. Strict biosafety isolation measures are not suitable for nucleic acid extraction of high-risk pathogen samples, and nucleic acid extraction is only a step in the whole process of nucleic acid detection

However, the existing on-site detection equipment is not highly automated, and it is difficult to meet the requirements of automatic processing of the whole process from samples directly to nucleic acid detection.

It can be seen that most of the existing equipment is positioned in the laboratory application, the functions are relatively scattered, lack of high-level biological protection design, and cannot realize the whole process of automatic disposal and detection of high-risk pathogenic microorganism samples

[0005] Most domestic and microbial nucleic acid detection equipment is aimed at ordinary microbial samples, so there is no biological protection design for high-risk pathogen microbial nucleic acid detection, and it is not suitable for independent nucleic acid detection of high-risk pathogen samples at infectious disease prevention and control sites or ordinary laboratories

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