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Glucose-responsive photonic crystal sensor, its preparation method and use method

A photonic crystal and responsive technology, applied in nanotechnology for sensing, color/spectral characteristic measurement, nanotechnology, etc., can solve the problems that response time hinders the development of glucose-responsive photonic crystal colorimetric sensors and limits applications, etc. Achieve the effects of easy operation, long response time and simple preparation method

Active Publication Date: 2020-10-30
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at this stage, the long response time hinders the development of glucose-responsive photonic crystal colorimetric sensors and limits their applications.

Method used

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  • Glucose-responsive photonic crystal sensor, its preparation method and use method
  • Glucose-responsive photonic crystal sensor, its preparation method and use method
  • Glucose-responsive photonic crystal sensor, its preparation method and use method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Disperse superparamagnetic nanoparticles (consisting of ferric oxide nanocrystal cluster core and polyvinylpyrrolidone coated on its surface) into 3-acrylamidophenylboronic acid (AAPBA), N-(2- Hydroxyethyl) acrylamide (HEAA), photoinitiator 2-hydroxy-2-methyl-1-phenylacetone (HMPP), cross-linking agent methylenebisacrylamide (BIS), dimethyl sulfoxide and water Form the pre-poly solution in the solution; in the pre-poly solution: the concentration of AAPBA is 0.023mmol / mL, the concentration of HEAA is 0.20mmol / mL, the concentration of HMPP is 3% of the molar weight of AAPBA and HEAA monomer, and the concentration of BIS is The molar weight of AAPBA and HEAA monomers is 2%, the concentration of selected superparamagnetic nanoparticles is 1.0mg / mL, the particle diameter is 120nm, and the volume ratio of dimethyl sulfoxide to water is 100 / 900.

[0055] (2) Place the pre-polymerization solution under an external magnetic field of 250Gs, and after standing still for 2 min...

Embodiment 2

[0062] (1) Disperse superparamagnetic nanoparticles (consisting of iron ferric oxide nanocrystal cluster core and polyvinylpyrrolidone coated on its surface) into 3-acrylamidophenylboronic acid (AAPBA), acrylamide (AM) , photoinitiator 2-hydroxyl-2-methyl-1-phenylacetone (HMPP), crosslinking agent methylene bisacrylamide (BIS) and dimethyl sulfoxide and water to form a pre-poly solution; In the polymer solution: the concentration of AAPBA is 0.023mmol / mL, the concentration of AM is 0.20mmol / mL, the concentration of HMPP is 3% of the molar weight of AAPBA and AM monomer, and the concentration of BIS is 2% of the molar weight of AAPBA and AM monomer. %, the concentration of the selected superparamagnetic nanoparticles is 1.0 mg / mL, the particle diameter is 150 nm, and the volume ratio of dimethyl sulfoxide to water is 100 / 900.

[0063] (2) Place the pre-polymerization solution under an external magnetic field of 250Gs, and after standing still for 2 minutes, cure it with an ultr...

Embodiment 3

[0067] (1) Disperse the superparamagnetic nanoparticles (composed of ferric oxide nanocrystal cluster inner core and polyvinylpyrrolidone coated on its surface) into 3-acrylamidophenylboronic acid (AAPBA), photoinitiator 2- Hydroxy-2-methyl-1-phenylacetone (HMPP), cross-linking agent methylene bisacrylamide (BIS), dimethyl sulfoxide and water to form a prepolymer solution; in the prepolymer solution: AAPBA The concentration is 0.012mmol / mL, the concentration of HMPP is 5% of the molar weight of AAPBA monomer, the concentration of BIS is 2% of the molar weight of AAPBA monomer, and the concentration of selected superparamagnetic nanoparticles is 1.0 mg / mL. The diameter is 120nm, and the volume ratio of dimethyl sulfoxide to water is 400 / 600.

[0068] (2) Place the pre-polymerization solution under an external magnetic field of 250Gs, and after standing still for 2 minutes, cure it with an ultraviolet lamp for 5 minutes. After the reaction, wash the prepared photon nanochains wi...

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Abstract

The invention relates to the field of photonic crystal materials and glucose detection, in particular to a glucose responsive photonic crystal sensor, and a preparation method and a use method thereof. The glucose responsive photonic crystal sensor comprises a plurality of glucose responsive gel shell layers and magnetic cores wrapped by the glucose responsive gel shell layers. The glucose responsive photonic crystal sensor disclosed by the invention is used for rapidly detecting the glucose concentration. Since the thickness of the glucose responsive gel shell layer coated on the surface of the magnetic core is only dozens of nanometers, compared with a traditional film-shaped glucose responsive photonic crystal sensor whose the thickness of the gel layer is tens of microns or even hundreds of microns, the thickness of the gel layer is reduced by three orders of magnitudes, the time required for diffusion of glucose in the gel layer is remarkably shortened due to the small thickness of the gel layer, the balance state can be rapidly achieved, and the problems that in the prior art, glucose responsive photonic crystals are large in size and long in response time, and the response speed reaches the second level are solved.

Description

technical field [0001] The invention relates to the fields of photonic crystal materials and glucose detection, in particular to a glucose-responsive photonic crystal sensor, a preparation method and a use method thereof. Background technique [0002] Glucose-responsive photonic crystal colorimetric sensors can diffract beautiful structural colors under white light irradiation. They are composed of ordered lattice structures of photonic crystals and gels containing glucose-responsive functional groups. The structural colors follow the Bragg diffraction law. It mainly depends on factors such as the lattice constant and the refractive index of the lattice structure. The most important thing is that its color changes continuously and reversibly with the change of glucose concentration in the visible spectrum range, because the glucose-responsive functional groups in the gel, such as phenylboronic acid, will form reversible five-membered or Six-membered cyclic lactone, when the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/25B82Y15/00
CPCB82Y15/00G01N21/25
Inventor 罗巍蔡锦阳潘娟娟马会茹官建国
Owner WUHAN UNIV OF TECH