Rapid calculation method of microcirculation resistance based on fractional blood flow reserve and blood flow resistance model

Abstract

The present invention proposes a method for quickly calculating coronary microcirculation resistance in combination with fractional flow reserve (FFR) and a blood flow resistance model, comprising: calculating parameters of a blood vessel segment blood flow resistance model of interest based on coronary CT angiography images; The arterial microcirculation resistance is simulated as a pure resistance unit and connected in series with the calculated blood flow resistance model to form a lumped parameter model; with the proximal pressure measured by FFR as the known condition and the preset coronary microcirculation resistance value, the equation is solved Obtain the distal pressure value; compare the simulated distal pressure value with the FFR measured distal pressure value, iteratively adjust the coronary microcirculation resistance value until the difference between calculation and simulation is less than the preset threshold; extract the adjusted model microcirculation resistance value The circulatory resistance value is used as the calculated value of coronary microcirculation resistance; taking the invasive FFR measurement results as the known conditions, based on the blood flow resistance model, the blood flow and microcirculation resistance matching the FFR measurement results are quickly simulated to obtain. Combined with the blood flow resistance model, the present invention improves the accuracy while avoiding synchronous measurement of blood flow; at the same time, compared with other iterative solution methods, the present invention uses the blood flow resistance model to simplify the iterative solution of fluid control equations to solve the unary two Subequation, the speed has been greatly improved.

Description

technical field [0001] The invention relates to the field of microcirculation calculation, in particular to a method for calculating microcirculation resistance combined with a fractional flow reserve (FractionalFlow Reserve, FFR) and a blood flow resistance model. Background technique [0002] The present invention is based on my patent invention with the publication number CN107411767A, entitled "A Non-invasive Method for Evaluating Blood Flow Resistance of Stenotic Lesions Based on Coronary CT Angiography". [0003] Coronary microcirculatory resistance (microcirculatory resistance, MR) is an effective index to reflect the function of coronary microcirculation, which is defined as the distal coronary artery pressure (P d ) divided by the coronary blood flow (Q max ). Existing technologies are mainly divided into two types: invasive and non-invasive: [0004] The first type of method uses a guide wire integrated with a pressure sensor and a blood flow sensor to be insert...

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Problems solved by technology

[0006] Although the above-mentioned technologies have given methods for determining MR from different angles and different calculation methods, they all have at least the following technical defect, that is, it is impossible to accurately measure (or calculate) Q in the state of maximum hyperemia max : The first type of method cannot accurately measure Q due to the measurement principle and the influence of catheter placement on blood flow. max ; the second type of method uses the estimated Q max way, the accuracy is difficult to guarantee

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