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Application of compound and pharmaceutical composition thereof in chronic diabetic complications

A compound, complication technology, applied in the field of medicine

Inactive Publication Date: 2020-05-12
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report about the application of the sesquiterpene lactone compound provided by the present invention or its pharmaceutical composition in the prevention, treatment or auxiliary treatment of chronic complications of DM

Method used

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  • Application of compound and pharmaceutical composition thereof in chronic diabetic complications
  • Application of compound and pharmaceutical composition thereof in chronic diabetic complications
  • Application of compound and pharmaceutical composition thereof in chronic diabetic complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the preparation method of formula (I) compound

[0021] 1.1 The preparation route of formula (I) compound (attachment figure 1 )

[0022] 1.2 The preparation process of the compound of formula (I) (attached figure 2 )

Embodiment 2

[0023] Embodiment 2: Anti-DM chronic complication activity test of formula (I) compound

[0024] Chronic complications of DM are the main cause of disability and death in DM. Its pathogenesis involves polyol bypass, protein kinase C, activation of hexosamine, and production of advanced glycation end products. In recent years, it has been found that hyperglycemia-induced mitochondrial response Increased production of sexual oxidation products is a possible common basis. Activation of reduced nicotinamide adenine dinucleotide oxidase is increasingly recognized as the central link in high glucose-induced oxidative stress. High glucose leads to protein uncoupling by causing Overexpression of mitochondrial peroxides causes oxidative stress and ultimately DNA damage. At the same time, from in vitro model tests and pathological examinations to epidemiological studies, many evidences have shown that inflammation is also one of the main pathogenesis of chronic complications of diabetes...

Embodiment 3

[0101] Embodiment 3: injection

[0102] After the compound prepared in Example 1 was dissolved with a small amount of DMSO, water for injection was added as usual, finely filtered, potted and sterilized to make an injection.

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PUM

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Abstract

The invention relates to application of dimethylamino-micheliolide fumarate in chronic diabetic complications, belongs to the technical field of drugs, and particularly relates to application of a compound shown as a formula (I) in prevention, treatment or adjuvant treatment of the chronic diabetic complications and application of the compound in preparation of drugs for prevention, treatment or adjuvant treatment of the chronic diabetic complications.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of a sesquiterpene lactone compound and a pharmaceutical composition thereof in the prevention, treatment or auxiliary treatment of chronic complications of diabetes mellitus (DM). Background technique [0002] With the improvement of living standards, changes in lifestyle and population aging, the prevalence of DM is increasing rapidly. According to the research data of the International DM Association in 2015, there are about 415 million DM patients in the world. It has become a developed country after cardiovascular diseases and tumors. the third leading chronic non-communicable disease. The prevalence of DM in my country has grown explosively in recent years, from 5.5% in 2000 to 10.9% in 2013. Therefore, DM is a worldwide public health problem that seriously endangers human health. [0003] Due to the discovery and wide application of insulin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P3/10A61P29/00A61P13/12
CPCA61K31/365A61P3/10A61P29/00A61P13/12
Inventor 龙海波
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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