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Multifunctional iron-hybridized mesoporous silica nano-carrier and preparation method thereof

A technology of mesoporous silica and nano-carriers, which is applied in the direction of silica, silicon oxide, and pharmaceutical formulations, and can solve the problems that the penetration depth of light hinders the application of photodynamic therapy.

Inactive Publication Date: 2020-05-12
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the insufficient penetration depth of light seriously hinders the application of photodynamic therapy, so the development of a nanocarrier that can directly catalyze and mediate the generation of hydroxyl radicals without using any externally applied stimuli has attracted attention.

Method used

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  • Multifunctional iron-hybridized mesoporous silica nano-carrier and preparation method thereof
  • Multifunctional iron-hybridized mesoporous silica nano-carrier and preparation method thereof
  • Multifunctional iron-hybridized mesoporous silica nano-carrier and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] Step 1) The preparation method steps of iron hybrid silica nanoparticles are as follows:

[0028] 1) 10 milliliters of solutions of cetyltrimethylammonium bromide with a final concentration of 1% are prepared in the single-necked bottle;

[0029] 2) Add 5 ml of absolute ethanol and 100 microliters of ethylene glycol amine, heat at 50° C., and stir for 30 minutes under magnetic conditions of 400 rpm;

[0030] 3) Add 0.1 ml of tetraethyl orthosilicate to the one-mouth bottle, heat at 60°C, stir and react for 10 minutes under 600 rpm magnetic condition, then add ferric nitrate (approximately 20:1 Si / Fe ratio ) into the reaction solution and then stirred and reacted for 30 to 40 minutes at 400 to 500 rpm;

[0031] 4) Immediately after the reaction, centrifuge at 12,000 rpm for 20 minutes, and wash the precipitate with absolute ethanol 3 times to obtain iron hybrid silica nanoparticles.

[0032] Step 2) The preparation method of iron hybrid mesoporous silica nano-carrier i...

Embodiment 2

[0037] Step 1) The preparation method steps of iron hybrid silica nanoparticles are as follows:

[0038] 1) 10 milliliters of solutions of cetyltrimethylammonium bromide with a final concentration of 1% are prepared in the single-necked bottle;

[0039] 2) Add 7 ml of absolute ethanol and 100 microliters of ethylene glycol amine, heat at 50°C, and stir for 30 minutes under magnetic conditions of 400 rpm;

[0040] 3) Add 0.1 ml of tetraethyl orthosilicate to the one-mouth bottle, heat at 60°C, stir and react for 10 minutes under 600 rpm magnetic condition, then add ferric nitrate (approximately 20:1 Si / Fe ratio ) into the reaction solution and then stirred and reacted for 30 minutes at 400 rpm;

[0041] 4) Immediately after the reaction, centrifuge at 12,000 rpm for 20 minutes, and wash the precipitate with absolute ethanol 3 times to obtain iron hybrid silica nanoparticles.

[0042] Step 2) The preparation method of iron hybrid mesoporous silica nano-carrier is as follows: ...

Embodiment 3

[0047] Step 1) The preparation method steps of iron hybrid silica nanoparticles are as follows:

[0048] 1) 15 milliliters of solutions of cetyltrimethylammonium bromide with a final concentration of 1.5% are prepared in the single-necked bottle;

[0049] 2) Add 7 ml of absolute ethanol and 150 microliters of ethylene glycol amine, heat at 50°C, and stir for 20 minutes under magnetic conditions of 400 rpm;

[0050]3) Add 0.15 ml of tetraethyl orthosilicate to the single-mouth bottle, heat at 60°C, and stir for 20 minutes under magnetic conditions of 700 rpm ) into the reaction solution and then stirred and reacted for 30 minutes at 400 rpm;

[0051] 4) Immediately after the reaction, centrifuge at 12,000 rpm for 25 minutes, and wash the precipitate 3 times with absolute ethanol to obtain iron hybrid silica nanoparticles.

[0052] Step 2) The preparation method of iron hybrid mesoporous silica nano-carrier is as follows:

[0053] 1) Take 15 mg of the prepared iron-hybrid sil...

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Abstract

The invention relates to a multifunctional iron-hybridized mesoporous silica nano-carrier and a preparation method thereof. According to the method, based on mesoporous silica particles, a ferric nitrate metal salt is doped in the synthesis process to successfully construct the iron-hybridized mesoporous silica nano-carrier with a particle size in a range of 120 + / - 20 nanometers; the carrier cangenerate a large number of hydroxyl radicals with cytotoxicity through a Fenton reaction in a tumor environment, and released iron ions are enriched in tumor cells to induce an iron death and necrosispathway of the tumor cells, so effective killing of the tumor cells is realized. The synthesis process is simple, convenient, non-toxic, quick and high in yield. In an in-vitro cytotoxicity test, a cell survival rate is 91.69%-99.79%, and the multifunctional iron-hybridized mesoporous silica nano-carrier has good biological safety.

Description

technical field [0001] The invention relates to a multifunctional iron hybrid mesoporous silicon dioxide nano carrier and a preparation method thereof. Background technique [0002] Currently, photodynamic therapy (PDT) is widely used in the development of cancer treatment strategies. The method is based on the generation of cytotoxic reactive oxygen species (ROS) by light, and the singlet oxygen can oxidize with nearby biomacromolecules, thereby achieving the killing of tumor cells. However, the insufficient penetration depth of light seriously hinders the application of photodynamic therapy, so the development of a nanocarrier that can directly catalyze and mediate the generation of hydroxyl radicals without using any externally applied stimuli has attracted attention. Hydrogen peroxide (H 2 o 2 ) and the mixed solution of ferrous ions have strong oxidizing properties, and after the reaction, hydroxyl radicals can be generated, which is called Fenton reaction. The Fent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18A61K41/00A61K47/04A61P35/00
CPCC01B33/18A61K41/0057A61K47/02A61P35/00C01P2004/62
Inventor 常津杨涵武晓丽张越魏道河段玥高俊潇
Owner TIANJIN UNIV
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