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A kind of thermosensitive coacervate type hyperbranched polyethylene glycol and its preparation method and application
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A technology of polyethylene glycol and polyethylene glycol diacrylate, which is applied in the field of temperature-sensitive coacervate type hyperbranched polyethylene glycol and its preparation, and can solve problems such as complex synthesis processes
Active Publication Date: 2021-11-19
XI AN JIAOTONG UNIV
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[0004] At present, the coacervate polymers are mainly of the coil-globule type, such as specific types of elastin-like polypeptides (ELPs), while the temperature-sensitive coacervate polymers are relatively rare, and only a few The temperature-sensitive coacervate-type polymerization process of polyesters is relatively complicated. It needs to carry out multi-step organic chemical reactions to synthesize monomers, and then carry out polymerization to obtain products.
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[0045] The invention discloses a method for preparing thermosensitive coacervate type hyperbranched polyethylene glycol, comprising the following steps:
[0046] 1) A certain amount of polyethylene glycol diacrylate (PEGDA575, with a molecular weight of 575Da), diethylene glycol diacrylate (DEGDA) and chain transfer agent 4-cyano-4-(thiobenzoyl)pentyl Add the acid (CPADB) into the three-necked flask containing the reaction solvent butanone and fully dissolve the monomer by magnetic stirring. The molar ratio of PEGDA575, DEGDA and CPADB is (75-90): (25-10): 1 ;
[0047] 2) Deoxygenation by nitrogen bubbling for 30 minutes;
[0048] 3) Add the initiator azobisisobutylcyanide (AIBN) quickly under the condition of blowing nitrogen, and continue blowing nitrogen for 5 minutes; wherein, the molar ratio of AIBN and CPADB is 0.5:1.
[0049] 4) Submerge the three-necked bottle into an oil bath preheated to 60-85°C to start the reaction;
[0050] 5) Monitoring polymer molecular weigh...
Embodiment 1
[0059] The reaction ratio of polyethylene glycol diacrylate (PEGDA575), diethylene glycol diacrylate (DEGDA), chain transfer agent (CPADB), and initiator (AIBN) is 75:25:1:0.5, at 70°C Under the temperature, react 8h; The product molecular weight that obtains is 20000Da, see figure 2 .
Embodiment 2
[0061] The reaction ratio of polyethylene glycol diacrylate (PEGDA575), diethylene glycol diacrylate (DEGDA), chain transfer agent (CPADB), and initiator (AIBN) is 80:20:1:0.5, at 70°C Under the temperature, react 8h; The product molecular weight that obtains is 40000Da, see image 3 . .
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Abstract
The invention discloses a temperature-sensitive coacervate type hyperbranched polyethylene glycol, a preparation method and application thereof, and belongs to the field of biomedical materials. The temperature-sensitive coacervate type hyperbranched polyethylene glycol disclosed by the invention has a relatively large range of phase transition temperature by changing its composition ratio, molecular weight and branching degree. The invention also discloses its preparation method, that is, using polyethylene glycol diacrylate, diethylene glycol diacrylate, chain transfer agent and initiator under anaerobic conditions, and preparing it through reversible addition-fragmentation chain transfer radical polymerization have to. The preparation method is simple and efficient, the raw materials used are cheap and easy to obtain, and the production cost is well reduced. At the same time, the temperature-sensitive coacervate-type hyperbranched polyethylene glycol and mercapto-gelatin are cross-linked to prepare an injectable hydrogel. Due to the good biocompatibility of thermosensitive coacervate type hyperbranched polyethylene glycol, it can be applied in the fields of drug / protein purification, delivery, single cell encapsulation, injectable tissue engineering hydrogel scaffold and so on.
Description
technical field [0001] The invention belongs to the field of biomedical materials, and relates to a temperature-sensitive coacervate type hyperbranched polyethylene glycol and a preparation method and application thereof. Background technique [0002] Because coacervate polymers are not completely dehydrated, they will not cause significant changes in molecular conformation, so they have a wide range of applications in the fields of biomaterials, for example, they can be used to wrap biological macromolecules such as proteins without damaging their biological activity. Layered polymers are used as purification reagents for proteins and nucleic acids, controllable delivery vehicles for sensitive physiologically active molecules, and injectable tissue engineering scaffolds. For example, the current purification of proteins and nucleic acids mainly relies on electrophoresis and chromatographic column methods. The process is relatively cumbersome and the efficiency is low. Howev...
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