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Hot flash ameliorant

A technology for hot flashes and improving agents, which can be used in drug combinations, plant/algae/fungus/moss components, sexual diseases, etc., and can solve problems such as increased risk of cancer

Inactive Publication Date: 2020-05-15
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hormone therapy has concerns about side effects such as an increase in the risk of cancer, so it is desired to improve various symptoms of menopause more safely

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0155] Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited thereto.

reference example 1

[0157] (1) Determination of chlorogenic acids

[0158] [analytical equipment]

[0159] Use HPLC.

[0160] Device: Waters ACQUITY UPLC-H Class PDA

[0161] Separation column: ACQITY UPLC HSS C18 2.1×100mm, 1.8μm

[0162] Detector (ultraviolet-visible absorbance photometer): L-2420

[0163] [Analysis conditions]

[0164] Sample injection volume: 10μL,

[0165] Flow: 1.0mL / min,

[0166] Ultraviolet Absorption Photometer Detection Wavelength: 325nm

[0167] Eluent A: 5% (v / v) acetonitrile containing 0.05mol / L acetic acid, 0.01mol / L sodium acetate and 0.1mmol / L HEDPO (1-hydroxyethane-1,1-diphosphonic acid),

[0168] Eluent B: Acetonitrile

[0169] [Concentration gradient conditions]

[0170]

[0171] [Retention time of chlorogenic acids]

[0172] 3-caffeoylquinic acid (3-CQA): 5.2min

[0173] 5-caffeoylquinic acid (5-CQA): 8.7min

[0174] 4-caffeoylquinic acid (4-CQA): 11.2min

[0175] 3-Feruloylquinic acid (3-FQA): 12.6min

[0176] 5-feruloylquinic acid (5-FQA): 19....

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Abstract

Provided is a material that improves menopausal symptoms such as hot flashes. An oral hot-flash ameliorant having a chlorogenic acid as an active ingredient. An oral hot-flash ameliorant having, as anactive ingredient, a coffee bean extract that contains a chlorogenic acid and has a mass ratio of caffeine / chlorogenic acid of 0.015 or less.

Description

technical field [0001] The present invention relates to an agent for improving hot flushes, one of menopausal symptoms. Background technique [0002] Menopausal symptoms and menopausal disorders are poor physical conditions caused by drastic changes or decreases in the secretion of sex hormones that accompany aging. During menopause, symptoms such as heart palpitations, sweating, hot flashes (fever or dizziness), chills, stiff shoulders or low back pain, headaches, insomnia, and anxiety appear. Among them, hot flashes are one of the representative symptoms of menopause. Hormone replacement therapy, which supplements hormones such as estrogen, has been performed for menopausal disorders with severe symptoms. However, hormone therapy has concerns about side effects such as an increase in the risk of cancer, and therefore, it is desired to improve various symptoms of menopause more safely. [0003] Chlorogenic acids are one of the polyphenols found in green coffee beans. As...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A23L33/105A61K9/08A61K36/74A61P15/12A61K131/00
CPCA23L33/105A61K9/08A61K31/216A61K36/74A61P15/12A61K31/522A61K2300/00A61K9/0053A61K31/235
Inventor 铃木淳
Owner KAO CORP