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Tibetan tea prescription for improving sleep, prescription extract and its preparation method and application

A technology for improving sleep and extracts, applied in the field of Tibetan pharmacy, can solve the problems of incompatibility, difficult to take long-term medication, no effect on direct sleep, etc., and achieve the effect of improving sleep.

Active Publication Date: 2021-11-23
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, apart from the chemical sleeping pills and sedatives that directly induce sleep, there are no ideal drugs that can improve sleep but have no effect on direct sleep.
With the clinical use, the side effects of chemical hypnotics and sedatives that directly lead to sleep are becoming more and more prominent, and it is not easy to take long-term medication, and it is not suitable as a daily sleep-improving drug application.

Method used

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  • Tibetan tea prescription for improving sleep, prescription extract and its preparation method and application
  • Tibetan tea prescription for improving sleep, prescription extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The sleep-improving Tibetan tea recipe of this example is composed of fried nettle leaves and narrow-leaved Xianbei flowers and leaves, and the mass ratio of the nettle leaves and narrow-leaved Xianbei flowers and leaves is 1:1 The frying process of the nettle leaves is as follows: pick fresh nettle leaves from May to June, fry them for 4h to 5h at a temperature of 47°C to 50°C, and then drop them to room temperature naturally after frying; The frying process of Xianbei flower leaves is as follows: collect the fresh leaves of Xianbei flowers from May to July, fry them at a temperature of 50°C-55°C for 3h-4h, and let them cool down to room temperature naturally after frying.

Embodiment 2

[0019] The sleep-improving Tibetan tea prescription extract of this embodiment is obtained by pulverizing the sleep-improving Tibetan tea prescription of Example 1, soaking in water, heating to reflux, and concentrating and drying.

[0020] The method that present embodiment prepares above-mentioned Tibetan tea prescription extract for improving sleep is:

[0021] Pulverize the sleep-improving Tibetan tea recipe in Example 1 to obtain a mixture with a particle size of ≤150 μm, then add pure water a, soak for 2 hours, and then reflux at a temperature of 130°C for 3 hours, then collect the extract a, then add pure water b to the filter residue b, heat reflux at a temperature of 130°C for 3 hours, collect the extract b, then add pure water c to the filter residue c, heat reflux at a temperature of 130°C After 3 hours, collect the extract c, combine the extract a, extract b and extract c to obtain the extract, concentrate and dry the extract, and obtain the extract of Tibetan tea ...

Embodiment 3

[0023] This example is a test of the effect of the Tibetan tea prescription extract prepared in Example 2 on improving sleep in KM mice.

[0024] (1) The effect of the test substance on the body weight of mice

[0025] After 3 days of adaptive feeding, 50 KM mice were randomly divided into 5 groups according to body weight, 10 in each group, respectively normal saline group (equal volume normal saline), diazepam group (diazepam tablet 10mg / kg, 1.25 mg / tablet, which is a commonly used drug for treating anxiety and insomnia), the low, medium and high dose groups of Tibetan tea prescription extracts (200mg / kg 体重 , 450mg / kg 体重 , 1000mg / kg 体重 ). Gastrointestinal administration of different drug solutions, 1 time / d, 0.1mL / 20g 体重 , Continuous administration for 66d. During the experiment, the daily food intake of the mice was recorded, and the body weight was weighed once every 2 days. They were allowed to eat and drink freely.

[0026] Table 1 Body weight of mice before and af...

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PUM

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Abstract

The present invention provides a sleep-improving Tibetan tea composition, which is composed of fried nettle leaves and fried narrow-leaf Xianbei flowers and leaves of equal quality; it also provides a sleep-improving Tibetan tea prescription extract, The Tibetan tea recipe that is about to improve sleep is made by crushing, soaking in water, heating to reflux, and concentrating and drying; the preparation method is also provided. After the Tibetan tea recipe is crushed, add pure water a, soak for 2 hours, and heat reflux at 130°C for 3 hours , collect the extract a, add pure water b to the filter residue b, heat reflux at 130°C for 3h, collect the extract b, add pure water c to the filter residue c, heat reflux at 130°C for 3h, collect the extract c, The combined extracts are concentrated and dried, and the application of the Tibetan tea prescription extracts is also provided, which can be used in tea or health care products for improving sleep. The invention has no direct sleep effect, can improve sleep, can promote the incidence of induced sleep, shorten sleep latency, prolong sleep time, and have no side effects after drug withdrawal.

Description

technical field [0001] The invention belongs to the technical field of Tibetan pharmacy, and in particular relates to a prescription of Tibetan tea for improving sleep, an extract of the prescription, a preparation method and application thereof. Background technique [0002] As our country enters the reality of aging and faster and faster pace of life, insomnia has become a serious factor affecting people's health and quality of life. At present, except for the chemical hypnotics and sedatives that directly cause sleep, there is no ideal drug that can improve sleep but has no effect on direct sleep. Along with clinical use, the side effects of chemical hypnotics and sedatives that directly lead to sleep are increasingly prominent, and it is not easy to take long-term medication, and it is not suitable as a daily drug application for improving sleep. Therefore, the development of food, health care products and medicines without side effects, direct sleep and sedative effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A23F3/34A61P25/20
CPCA23F3/34A61K9/0095A61K36/185A61K36/73A61K2236/10A61K2236/331A61K2236/39A61P25/20A61K2300/00
Inventor 郭肖李啟恩李先加卓玛本公保索安增太措吾坚旦增吉毛才让罗多文色
Owner QINGHAI UNIVERSITY