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Method for improving detection sensitivity of ion mobility spectrometer

A technology of detection sensitivity and ion mobility spectrometer, applied in the field of ion mobility spectrometry

Inactive Publication Date: 2020-06-09
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is: when the ion gate is opened and fixed in the existing ion mobility spectrometer, the number of ions in high-concentration and high-sensitivity samples is too much to exceed the detection range, and the number of ions in low-concentration and low-sensitivity samples is too small to be below the detection range. The range of problems provides a method to change the opening time of the ion gate to adjust the number of ions, reduce the number of ions entering the migration area of ​​high-concentration and high-sensitivity samples, and increase the number of ions of low-concentration and low-sensitivity samples entering the migration area to achieve detection Ion Mobility Spectrometry for Samples with Different Sensitivity

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Experimental program
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Effect test

Embodiment 1

[0034] Samples were analyzed by ion mobility spectrometer. The operating conditions were transfer tube temperature 120°C, injector temperature 220°C, dopant temperature 35°C, radio frequency lamp as ionization source, drift gas 500ml / min, carrier gas 250ml / min. After the 1 microliter sample standard liquid drop is dried on the sampling chip, it is inserted into the sample injector to start analysis for 10 seconds, and the data of 100-300 spectra are collected.

[0035] After ion mobility spectrometry sample injection, 200 consecutive analyzes are performed, and each analysis cycle is 20 milliseconds. The opening time of each analysis cycle for the first 100 times is 200 microseconds, and the opening time of each analysis cycle for the next 100 times is 1000 microseconds.

[0036] For the first 100 analyzes of sample A (200ng TNT), the maximum value of the detection signal peak was 1.5V.

Embodiment 2

[0038] Samples were analyzed by ion mobility spectrometer. The operating conditions were transfer tube temperature 120°C, injector temperature 220°C, dopant temperature 35°C, radio frequency lamp as ionization source, drift gas 500ml / min, carrier gas 250ml / min. After the 1 microliter sample standard liquid drop is dried on the sampling chip, it is inserted into the sample injector to start analysis for 10 seconds, and the data of 100 spectra are collected.

[0039] After ion mobility spectrometry sample injection, 100 consecutive analyzes are performed, each analysis period is 20 milliseconds, and the opening time of each analysis period for the first 50 times is 10 microseconds, and the opening time of each analysis period for the last 50 times is 50 microseconds. microseconds.

[0040] For the first 50 analyzes of sample A (200ng TNT), the maximum value of the detection signal peak was 0.1V.

Embodiment 3

[0042] Samples were analyzed by ion mobility spectrometer. The operating conditions were transfer tube temperature 120°C, injector temperature 220°C, dopant temperature 35°C, radio frequency lamp as ionization source, drift gas 500ml / min, carrier gas 250ml / min. After the 1 microliter sample standard liquid drop is dried on the sampling chip, it is inserted into the sample injector to start analysis for 10 seconds, and the data of 300 spectra are collected.

[0043] After ion mobility spectrometry sample injection, 300 consecutive analyzes are performed, and each analysis period is 20 milliseconds. The opening time of each analysis period for the first 150 times is 1000 microseconds, and the opening time of each analysis period for the next 150 times is 200 microseconds. microseconds.

[0044] For the first 150 analyzes of sample A (200ng TNT), the maximum value of the detection signal peak was greater than 3V.

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Abstract

The invention discloses a method for improving the detection sensitivity of an ion mobility spectrometry. The method is characterized in that continuous analysis for 200 times is carried out after sample introduction of the ion mobility spectrometry, the analysis period of each time is 20 milliseconds, the door opening time of each analysis period of the first 100 times is 200 microseconds, and the door opening time of each analysis period of the last 100 times is 1000 microseconds, so simultaneous detection of a high-concentration sample A and a low-concentration sample B is realized, and detection sensitivity is improved.

Description

technical field [0001] The invention belongs to the field of analytical instruments and detection, and in particular relates to an ion mobility spectrometry technology for improving the detection sensitivity of different samples by changing the opening time of an ion gate. Background technique [0002] Ion mobility spectrometry is a technology that uses the difference in ion mobility (K0) exhibited by ions formed by different compounds when they migrate in a uniform weak electric field under atmospheric pressure to achieve the separation and detection of target substances. The main component of the ion mobility spectrometer is the ion mobility tube, and its structure includes an ionization reaction area, an ion gate, a migration area, and a detector. Ion mobility spectrometry has the advantages of fast detection speed (single detection cycle less than 20ms), high sensitivity (solid ng to pg level), easy miniaturization and miniaturization, etc. [0003] The ion gate is one ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62G01N27/622
CPCG01N27/622
Inventor 李京华李东明李海洋
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI