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Compounds with antitumor activity and their preparation methods and applications

A technology of anti-tumor activity and anti-tumor drugs, which is applied in the field of medicine to achieve the effect of reasonable process design, high purity and strong anti-tumor activity

Active Publication Date: 2021-08-24
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, modern research has not completely clarified the material basis of anti-tumor effects before and after the treatment

Method used

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  • Compounds with antitumor activity and their preparation methods and applications
  • Compounds with antitumor activity and their preparation methods and applications
  • Compounds with antitumor activity and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. A method of preparing a compound of the present invention:

[0041] (1) Granules of bran: Wheat bran and branger with weight ratio of 1: 4, will preheat the gun special pot, put the wheat bran into the pot, and put the gantry film and stir fry until the Atractylodes Yellow yellow, overflow aroma; the fried temperature is 200 ° C, the time is 26 min.

[0042] (2) Number of bran (1) bran (1) bran, crushing after 40 mesh sieve, take at the atractylodes of 2.0kg, extract 2 times with 10L, 8L methanol, 2 hours each time, combine extract, minus The solvent was pressed, and the extract was 208.7 g after drying.

[0043] (3) After adding 2 L of the extract from the extract obtained by step (2), 2 L of n-hexane is added 2 times, combined with the extract, and the solvent is removed, and the n-hexane extract component is 40.37 g.

[0044] (4) Silica gel column chromatography in step (3): Silica 820g, Catalog # 40930-25, L26INCH * D3.5 inch, mixed solvent using n-hexane-chloroform ...

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Abstract

The invention discloses a compound with anti-tumor activity. Through systematic and in-depth research on the chemical components of Bran-fried Atractylodes Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, analysis of spectrum and mass spectrometry data shows that the compound with anti-tumor activity is isolated from Bran-fried Atractylodes Rhizoma Rhizome. Anti-tumor activity studies in vivo and in vitro show that the compound with anti-tumor activity provided by the present invention has strong inhibitory activity on various tumor cells such as lung adenocarcinoma, human brain glioma, human colon cancer or human liver cancer.

Description

Technical field [0001] The present invention relates to a compound having anti-tumor activity, and more particularly to an attestant ketone polymerized compound having anti-tumor activity from the atractylodia, which is a medical technology. Background technique [0002] Chinese medicine has thousands of years of application history, and Chinese medicine cannon is one of the characteristics of traditional Chinese medicine. Chinese medicine artillery technology will have a large change in drug material base itself, and the simultaneous changes of substance bases will also generate corresponding biological effects to the human body, resulting in clinically different therapeutic effects. The chemical composition with unique structural and active effect is found from the Chinese medicine guns, which is a method and idea of ​​a half-time. [0003] Atractylodes are the dry roots at Lech. The dry roots are one of the famous Chinese medicine "Zhejia", with the efforts of spleen, dry and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/92A61K31/343A61P35/00
CPCA61P35/00C07D307/92
Inventor 翟春梅韩路拓邸金霖刘一畅孟永海
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE