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Antibacterial application of beta 2 adrenergic receptor antagonist

An adrenergic, receptor technology for antibacterials, antifungals, resistance to vector-borne diseases, etc.

Active Publication Date: 2020-06-23
SHANDONG EYE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide an antibacterial application of a β2 adrenergic receptor antagonist, to solve the problem that the β2 adrenergic receptor antagonist is not used for antibacterial problem

Method used

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  • Antibacterial application of beta 2 adrenergic receptor antagonist
  • Antibacterial application of beta 2 adrenergic receptor antagonist
  • Antibacterial application of beta 2 adrenergic receptor antagonist

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Embodiment Construction

[0024] The present invention will be further described below with reference to the accompanying drawings and examples, and the embodiments of the present invention include but not limited to the following examples.

[0025] An antibacterial application of a β2 adrenergic receptor antagonist; the β2 adrenergic receptor antagonist has antibacterial activity; wherein, the antibacterial application of a β2 adrenergic receptor antagonist is ICI118551hydrochloride, and its chemical structure is as follows:

[0026]

[0027] Among them, the β2 adrenergic receptor antagonist can inhibit the activity of any one of Gram-negative bacteria, Gram-positive bacteria and fungi; the following are representative Escherichia coli, Staphylococcus aureus, Antibacterial activity of β2 adrenergic receptor antagonist ICI118551 hydrochloride against Staphylococcus epidermidis, Candida glabrata, and Fusarium solani.

[0028] The experimental process is as follows:

[0029] Experimental Materials: ...

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Abstract

The invention discloses an antibacterial application of a beta 2 adrenergic receptor antagonist, and mainly solves the problem that the beta 2 adrenergic receptor antagonist is not used for antibiosisnow. The antibacterial application of the beta 2 adrenergic receptor antagonist is characterized in that the beta 2 adrenergic receptor antagonist has the antibacterial activity. Through the above scheme, the invention achieves that the beta 2 adrenergic receptor antagonist has the antibacterial activity, reveals a new application value of the beta 2 adrenergic receptor antagonist, and has high practical value and popularization value.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to the antibacterial application of a β2 adrenergic receptor antagonist. Background technique [0002] Beta-adrenoceptor antagonists are a class of drugs that selectively bind to beta-adrenergic receptors, thereby antagonizing the agonistic effects of neurotransmitters and catecholamines on beta-receptors; adrenergic receptors are found in most sympathetic On the effector cell membrane dominated by postganglionic fibers, the receptors are divided into three types, which can be excited to cause increased heart rate and myocardial contractility, bronchiectasis, vasodilation, relaxation of visceral smooth muscle, etc., and fat decomposition. [0003] Adrenergic receptors are distributed on the effector cell membranes dominated by most sympathetic postganglionic fibers, and their receptors are divided into three types, namely β1 receptors, β2 receptors and β3 receptors; β1 receptors are ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/138A61P31/04A61P31/10
CPCA61K31/138A61P31/04A61P31/10Y02A50/30
Inventor 周庆军谢立信宋方英马修彬王群
Owner SHANDONG EYE INST