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Use of somatotropin-releasing hormone agonist ghrh-a in the preparation of anti-aging medicine

A GHRH-A, growth-promoting hormone technology, applied in the field of biomedicine, can solve the problems of unknown mechanism, pathway, undisclosed mechanism, pathway and experimental data, etc., to reduce the positive rate of staining, improve the shape and function of mitochondria, and prolong The effect of longevity

Active Publication Date: 2021-12-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it only briefly mentioned this effect in the patent, but did not disclose the specific mechanism, pathway and experimental data
Therefore, those skilled in the art still cannot know its specific mechanism, pathway etc.

Method used

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  • Use of somatotropin-releasing hormone agonist ghrh-a in the preparation of anti-aging medicine
  • Use of somatotropin-releasing hormone agonist ghrh-a in the preparation of anti-aging medicine
  • Use of somatotropin-releasing hormone agonist ghrh-a in the preparation of anti-aging medicine

Examples

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Embodiment

[0056] The present invention will be described through specific examples below. The GHRH-A used in this example is MR409, but the protection scope of the present invention is not limited thereto. The experimental methods described in the following examples, unless otherwise specified, are conventional methods; the reagents and materials, unless otherwise specified, can be obtained from commercial sources. Among them, MR409 is provided by Professor AndrewV.Schally of the University of Miami.

[0057] The amino acid sequence of MR409 is: N-Me-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Orn-Val-Leu-Abu-Gln-Leu-Ser-Ala-Arg -Orn-Leu-Leu-Gln-Asp-Ile-Nle-Asp-Arg-NHCH 3 . (i.e. N-methyltyrosine-D-alanine-aspartic acid-alanine-isoleucine-phenylalanine-threonine-asparagine-serine-tyrosine-arginine amino acid-ornithine-valine-leucine-2-aminobutyric acid-glutamine-leucine-serine-alanine-arginine-ornithine-leucine-leucine - Glutamine - Aspartic Acid - Isoleucine - Norleucine - Aspart...

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Abstract

The invention relates to the field of biomedicine, and discloses the use of a growth-stimulating hormone-releasing hormone agonist GHRH-A in the preparation of anti-aging drugs. The present invention finds that GHRH-A can resist aging, including reducing the positive rate of aging markers (-gal staining, reducing the expression of related protein p21 in the cell cycle of aging cells, and reducing the production of ROS. And GHRH-A improves the mitochondrial morphology and function of aging cells, Increase the expression of mitochondrial protein OPA1 and the ratio of long-form to short-form L / S-OPA1; improve cardiac function, that is, improve cardiac systolic and diastolic functions; at the same time, GHRH-A can improve the proportion of immune cells and immune ability of the body; increase the number of stem cells; Improve the body's exercise ability, promote hair growth, and improve survival rate. The drug has the characteristics of good stability and high drug activity, and is suitable for preventing and treating heart failure, reducing the aging systemic phenotype, and prolonging life.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the application of GHRH-A, a somatotropin-releasing hormone agonist, in the preparation of anti-aging drugs. Background technique [0002] Aging, also known as aging, is a natural and complex biological process that is a common feature of all animals. With the growth of age, the degenerative changes of physiological structure and functional decline appear in the aging body, and corresponding changes occur in the animal body from the levels of organs, tissues, cells, and molecules. The heart is an important organ that is greatly affected by age. In recent years, the aging of the population has become an important trend, and the ensuing elderly heart becomes left ventricular hypertrophy, diastolic dysfunction, atrial fibrillation, and thickening and hardness of the intima of the blood vessels that increase with age. In addition, studies have shown that pathological hypertrophy,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/25A61P39/06
CPCA61K38/25A61P39/06
Inventor 余红项平平A·V·沙利
Owner ZHEJIANG UNIV