An improved nano-suspension freeze-dried preparation based on Guanxinning and its preparation method
A technology of freeze-dried preparations and nano-suspensions, applied in the field of medicine
Active Publication Date: 2022-08-05
SOUTHWEST UNIV
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Problems solved by technology
[0006] The technical problem solved by the present invention is to provide an oral preparation containing insoluble and water-soluble components of Rhizoma Chuanxiong and Salvia miltiorrhiza at the same time, which solves the technical problem of improving the dissolution of insoluble components and improving their oral bioavailability
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[0049] The following descriptions of specific embodiments of the present invention illustrate but do not limit the present invention.
[0050] In order to achieve the purpose that the nano-suspension freeze-dried preparation of the present invention contains both water-soluble active ingredients and insoluble active ingredients, and the insoluble ingredients can also be effectively released and dissolved, the inventors of the present invention found when selecting raw materials, whether Guanxinning is taken orally. The preparation or the injection preparation adopts the water extract to carry out the follow-up process treatment. The ingredients contained in the preparation mainly include danshensu, protocatechualdehyde, ligustrazine, yangchuanxiongolide I, yangchuanxiongolide H, rosmarinic acid. , salvianolic acid B, etc., but the insoluble components such as yangchuanxiong lactone A, ligustilide, tanshinone I, and tanshinone IIA with clear efficacy reports are obviously missin...
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Abstract
The invention belongs to the field of medicine, and relates to an improved nano-suspension freeze-dried preparation based on Guanxinning and a preparation method thereof. The technical problem solved by the present invention is to provide an oral preparation containing both insoluble and water-soluble components of Chuanxiong and Salvia miltiorrhiza, which solves the technical problems of improving the dissolution of the insoluble components and improving their oral bioavailability. The oral preparation of the present invention is an oral freeze-dried preparation made from the extracts of Chinese medicinal materials Chuanxiong and Salvia miltiorrhiza as raw materials: the weight ratio of Salvia miltiorrhiza extract and Chuanxiong extract is 8-12:6-10; the preparation method is as follows: A 2. Preparation of nanosuspension: the salvia miltiorrhiza extract and the chuanxiong extract are made into a nanosuspension of 100-1000 nm; B. the nanosuspension obtained in step A is freeze-dried to make a freeze-dried powder. The apparent solubility of the poorly soluble components is significantly higher than that of the extract, the release rate in simulated gastric juice and simulated intestinal fluid in vitro is accelerated, and the cumulative release rate is also significantly increased, which provides a new technical idea for clinical application of Chuanxiong and Salvia miltiorrhiza.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to an improved nano-suspension freeze-dried preparation based on Guanxinning and a preparation method thereof. Background technique [0002] Guanxinning is a preparation made from Chuanxiong and Danshen as raw materials in a 1:1 weight ratio. The existing dosage forms are tablets and injections. Guanxinning has the effect of promoting blood circulation and removing blood stasis, dredging the pulse and nourishing the heart. It is mainly used for the treatment of coronary heart disease and angina pectoris. [0003] At present, the research on the components and pharmacological effects of the single herbs of Chuanxiong and Salvia miltiorrhiza shows that the main alkaloid (Ligustrazine) of Chuanxiong can improve blood rheology and protect coronary arteries, etc. ) has many functions such as anti-platelet accumulation, scavenging oxygen free radicals, and dilating blood vessels. Pharmacological e...
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IPC IPC(8): A61K9/19A61K47/26A61K47/20A61K36/537A61P9/10
CPCA61K36/537A61K36/236A61K9/19A61K47/26A61K47/20A61P9/10A61K2300/00
Inventor 张继芬
Owner SOUTHWEST UNIV