Method for simultaneously determining vitamin E and vitamin E acetate in electronic cigarette liquid
An electronic cigarette liquid and measurement method technology, which is applied in the field of tobacco chemistry, can solve the problems such as the lack of an exact limit on the additive dose and the potential safety hazards of electronic cigarette liquid products, and achieve the advantages of short retention time, reduced column loss, and good mass spectrometry vacuum degree. Effect
Active Publication Date: 2020-07-17
ZHENGZHOU TOBACCO RES INST OF CNTC
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Problems solved by technology
In 2019, the U.S. Centers for Disease Control and Prevention (CDC) reported that the inhalation of vitamin E acetate in the form of atomization in functional e-cigarette liquid products may be the main cause of "white lung disease" in e-cigarette consumers, and there is no exact dosage of it. These situations will bring safety hazards to e-cigarette liquid products
[0007] There is currently no research report on the analysis method of vitamin E acetate in e-cigarette liquid
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[0025] The present invention is further described by the following specific examples, but does not limit the present invention. The following is a further example description of the gas chromatography mass spectrometry detector selected ion monitoring mode analysis of vitamin E and vitamin E acetate in electronic cigarette liquid according to the present invention:
[0026] Content determination example:
[0027] (1) Sample pretreatment:
[0028] Accurately weigh 0.2 g of e-cigarette liquid into a conical flask, add 2 mL of deionized water and mix well, then add 5 mL of methyl tert-butyl ether extraction solution containing the internal standard substance n-heptadecane (concentration: 5 μg / mL) Ultrasonic oscillation for 10 min, then stand still for 10 min, then take the supernatant liquid into a chromatographic bottle, and analyze it by GC-MSD. The vitamin E and vitamin E acetate in the smoke liquid were detected by gas chromatography-mass spectrometry / selected ion monitorin...
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Abstract
The invention discloses a method for simultaneously determining vitamin E and vitamin E acetate in electronic cigarette liquid. The method is characterized by comprising the following steps of accurately weighing a certain amount of electronic cigarette liquid, uniformly mixing the electronic cigarette liquid with deionized water, extracting by using an organic solution containing an internal standard substance, standing for layering after the extraction is completed, putting 1mL of supernatant into a 2mL chromatographic bottle, and quantitatively detecting the contents of vitamin E and vitamin E acetate in the cigarette liquid at the same time by using gas chromatography-mass spectrometry / selection of ion monitoring mode (GC-MS / SIM). The method has the advantages that less sample amountand reagent amount are required, the operation is simple and fast, the short-time efficiency is high, the analysis sensitivity is high, the adding standard recovery rate is high, the precision is good, the method is suitable for analyzing large-batch samples, and the vitamin E and the vitamin E acetate in the electronic cigarette liquid can be simultaneously determined.
Description
technical field [0001] The invention relates to a quantitative analysis method for vitamin E and vitamin E acetate in electronic cigarette liquid, and belongs to the field of tobacco chemistry. Background technique [0002] E-cigarette is a product that atomizes e-liquid through an atomizer to deliver nicotine and / or other substances to the respiratory system. E-cigarette liquid is an important part of electronic cigarettes. It contains nicotine / tobacco extract, propylene glycol or glycerin solvent, and a small amount of flavors and fragrances. These components prepare samples with different tastes or functions to cater to consumers. needs and preferences. In recent years, the sales volume of e-cigarettes as a new type of tobacco product has increased sharply at home and abroad, and the tobacco industry in various countries has also taken e-cigarettes as one of the important development directions. health" issues are of great importance. [0003] Vitamin E, also known as ...
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IPC IPC(8): G01N30/02G01N30/60G01N30/06
CPCG01N30/02G01N30/60G01N30/06G01N2030/045G01N2030/062
Inventor 蔡君兰王冰余晶晶陈黎崔华鹏秦亚琼彭斌刘克建赵晓东潘立宁张晓兵刘绍锋
Owner ZHENGZHOU TOBACCO RES INST OF CNTC