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A kind of map2 mutant gene affecting pig hair follicle development and its application

A technology for mutating genes and hair follicles, which is applied in the field of MAP2 mutation genes that affect the development of pig hair follicles, to achieve accurate results and reduce false positives

Active Publication Date: 2021-09-21
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is necessary to study the related proteins and corresponding mutant genes that affect the development of pig hair follicles, and there is no relevant research report so far

Method used

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  • A kind of map2 mutant gene affecting pig hair follicle development and its application
  • A kind of map2 mutant gene affecting pig hair follicle development and its application
  • A kind of map2 mutant gene affecting pig hair follicle development and its application

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Experimental program
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Embodiment Construction

[0024] Step 1: A small number of hairless pigs were expanded according to the breeding theory, and 12 boar families containing hairless individuals were established. A total of 120 Large White pigs from the same field were collected, including 60 hairless individuals and 60 normal individuals; in preparation for later phenotypic verification and screening of candidate genes for hairless traits.

[0025] Step 2: Taking 19-day-old piglets as the research object (the comparison between hair shaft and follicle of hairless and normal pigs is the most obvious), measure the unit area (cm 2 ) hair shaft number. Detect the number of hair shafts on the same part of the back, and judge the pigs with the number of hair shafts less than or equal to 3 (mean + standard deviation) per square centimeter as hairless pigs, and those with more than or equal to 6 hair shafts (mean - standard deviation) as hairless pigs normal pig. At the same time, the back tissue was cut transversely and longit...

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Abstract

The invention provides a MAP2 mutant gene that affects the development of pig hair follicles. The mutant gene has 10 mutation sites, and its physical location is between 112155861 and 112424202 of pig chromosome 15. Its nucleotide sequence is as shown in SEQ ID NO : Shown in 1~4. The present invention has found the key gene of pig hairless traits, and the MAP2 mutant gene that affects the development of pig hair follicles can be applied to genotyping, screening, identification and assisted breeding of pigs, and the MAP2 mutated gene of the present invention is used for assisted breeding of pigs , can effectively select sows that can stably inherit hairless traits, and then can realize short-term, low-cost, and high-accuracy breeding of excellent disease model pigs, and secondly, it can also be used as an identification of hereditary alopecia The generated molecular markers can be further applied to the study of mammalian hair development.

Description

technical field [0001] The invention relates to the field of molecular biology and medicine, in particular to a MAP2 mutant gene affecting pig hair follicle development and its application. Background technique [0002] Humans are very concerned about hereditary hair loss and hair thinning, and the stability of hair follicle morphology and function is the key to a normal hair cycle. The morphological structure and function of hair follicles are congenital. People have done a lot of research on the genetic mechanism of hair follicles, hoping to solve the problem of hair loss from the source. Pigs are of great significance in medicine. The genetic homology between pigs and humans is very high. Their genomes are similar to those of humans, and their complexity and chromosomal composition are also relatively consistent. The conservation of syntenic regions between humans and pigs is similar to that between humans and mice. 3 times. Therefore, pigs are now used as ideal model a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6888C12N15/11
CPCC12Q1/6888C12Q2600/124C12Q2600/156
Inventor 丁向东蒋尧梅孟然
Owner CHINA AGRI UNIV