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Cirsium setosum flavone effervescent tablet as well as preparation method and application thereof

A technology of thistle flavonoids and effervescent tablets is applied in the field of Xiaoji flavonoid effervescent tablets and preparation thereof, and achieves the effects of simple preparation method, good effervescent effect and remarkable discharge of lochia

Inactive Publication Date: 2020-07-24
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the use of flavonoids from thistle extract in effervescent preparations

Method used

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  • Cirsium setosum flavone effervescent tablet as well as preparation method and application thereof
  • Cirsium setosum flavone effervescent tablet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] This example is used to illustrate a kind of effervescent tablet of thistle flavonoids of the present invention and its preparation method, comprising the following steps:

[0033] Step 1: Extraction and concentration of the flavonoids of thistle: Weigh the coarse powder of thistle, add 70% ethanol to make the coarse powder fully wet and even, add ethanol for 15-30 minutes, then ultrasonically extract once, 20 minutes each time, combine The filtrate was allowed to stand still to obtain the extract of thistle. The extract was heated and concentrated, then dried in an oven at 90°C for 2 hours, and the product obtained was the extract powder.

[0034] Step 2: Weighing of raw materials: Weigh 5% of the flavonoid extract powder prepared in step 1, 1.0% of steviol glycoside, 20% of citric acid, 10% of sodium bicarbonate, 2% of PEG6000, and 30% of lactose according to the parts by weight %.

[0035] Step 3: According to the ratio described in step 2, pass the first part of this...

Embodiment 2

[0040] This example is used to illustrate a kind of effervescent tablet of thistle flavonoids of the present invention and its preparation method, comprising the following steps:

[0041] Step 1: Extraction and concentration of flavonoids from thistle: Weigh the coarse powder of thistle, add 80% ethanol to make the coarse powder fully wet and uniform, then soak in ethanol for 20 minutes, then ultrasonically extract twice, 30 minutes each time, combine the filtrates, Stand still to obtain the extract of thistle, heat and concentrate the extract and put it in an oven for 3 hours at 105°C to dry, and the product obtained is the extract powder.

[0042] Step 2: Weighing of raw materials: Weigh respectively 11% of the flavonoid extract powder prepared in step 1, 1.5% of steviol glycoside, 29% of citric acid, 16% of sodium bicarbonate, 4% of PEG 6000, and lactose according to the parts by weight 38.5%.

[0043] Step 3: According to the ratio described in step 2, pass the first part...

Embodiment 3

[0048] This example is used to illustrate a kind of effervescent tablet of thistle flavonoids of the present invention and its preparation method, comprising the following steps:

[0049] Step 1: Extraction and concentration of flavonoids from thistle: Weigh the coarse powder of thistle, add 90% ethanol to make the powder fully wet and even, add ethanol for 30 minutes, then ultrasonically extract 3 times, 40 minutes each time, combine the filtrates, Stand still to obtain the extract of thistle, heat and concentrate the extract, then put it into an oven for 4 hours to dry at 120°C, and the obtained product is the extract powder.

[0050] Step 2: Weighing of raw materials: Weigh 15% of the flavonoid extract powder prepared in step 1, 2.5% of steviol glycoside, 40% of citric acid, 20% of sodium bicarbonate, 6% of PEG6000 and 40% of lactose according to the parts by weight %.

[0051] Step 3: According to the ratio described in step 2, pass the first part of thistle flavonoid ext...

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Abstract

The invention belongs to the field of effervescent drink preparations, and relates to a Cirsium setosum flavone effervescent tablet as well as a preparation method and application thereof. The Cirsiumsetosum flavone effervescent tablet comprises the following raw materials: 5-15% of Cirsium setosum flavone extract powder, 1.0-2.5% of stevioside, 20-40% of citric acid, 10-20% of sodium bicarbonate, 2-6% of PEG 6000 and 30-40% of lactose. The Cirsium setosum flavone effervescent tablet has significant effects on postpartum hemorrhage (PPH), lochia discharge and uterine contraction of women.

Description

technical field [0001] The invention belongs to the field of effervescent beverage preparations, and more specifically relates to a small thistle flavonoid effervescent tablet and a preparation method and application thereof. Background technique [0002] Worldwide, more than 500,000 women die each year from complications related to pregnancy and childbirth. Recent studies have found that postpartum hemorrhage is still the leading cause of maternal morbidity and mortality, accounting for 25%-30% of maternal deaths. [0003] Postpartum hemorrhage (PPH) refers to the amount of vaginal bleeding exceeding 500 mL within 24 hours after delivery of the fetus, or the amount of vaginal bleeding exceeding 1000 mL within 24 hours after cesarean delivery. Postpartum hemorrhage is a serious and common complication in obstetrics, accounting for 18% of the total number of deliveries. Postpartum hemorrhage is closely related to severe obstetric complications such as hemorrhagic shock, dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K36/28A61K47/02A61K47/12A61K47/26A61K47/10A61P7/04A61P15/00
CPCA61K9/0007A61K9/2009A61K9/2013A61K9/2018A61K9/2031A61K9/2095A61K36/28A61K2236/333A61K2236/39A61P7/04A61P15/00
Inventor 刘志伟李明杨海琦李合李豫强王晓梦
Owner WUHAN POLYTECHNIC UNIVERSITY