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Application of a kind of traditional Chinese medicine composition in preparation of medicine for treating psoriasis

A composition and technology for psoriasis, applied in the directions of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of many adverse reactions, short remission period, high treatment cost, and achieve the effect of good therapeutic effect

Active Publication Date: 2022-01-11
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical practice has proved that the above-mentioned drugs and therapies have a short remission period, many adverse reactions, and high treatment costs.

Method used

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  • Application of a kind of traditional Chinese medicine composition in preparation of medicine for treating psoriasis
  • Application of a kind of traditional Chinese medicine composition in preparation of medicine for treating psoriasis
  • Application of a kind of traditional Chinese medicine composition in preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 Chinese medicine composition ointment

[0028] The Chinese medicine composition of the present embodiment is made from following crude drug:

[0029] Vinegar Corydalis 107.5g, Chuanxiong 86g, Clematis 86g, Fangfeng 107.5g, Zanthoxylum bungeanum 107.5g, Achyranthes bidentata 86g, Shenjincao 107.5g, Northeast Sperantophyllum 107.5g, Passepartout 86g, Pittosporum bark 107.5g, mint Brain 3.6g, borneol 7.2g, triethanolamine 16g, glycerol 100g.

[0030] Pepper, Chuanxiong, and Fangfeng steam distillation to extract volatile oil for 8 hours, collect volatile oil; add 10 times the amount of water to extract the medicinal residue for 1 hour, filter the extract, and use the filtrate for later use; , Pittosporum, Achyranthes bidentata, and Clematis add 10 times the amount of 70% ethanol, heat and reflux for extraction twice (1 hour / time), combine the extracts, filter, recover ethanol, merge with the above-mentioned water extraction part filtrate, a...

Embodiment 2

[0032] The preparation of embodiment 2 Chinese medicine composition gel

[0033] The traditional Chinese medicine composition of this example is made from the following raw materials: vinegar Corydalis 107.5g, Rhizoma Chuanxiong 86g, Clematis 86g, Fangfeng 107.5g, Zanthoxylum bungeanum 107.5g, Achyranthes bidentata 86g, Shenjincao 107.5g, Northeast Speranium 107.5g .

[0034] Extract volatile oil from Zanthoxylum bungeanum, Chuanxiong, and Fangfeng by steam distillation for 6 hours, collect the volatile oil; add 12 times the amount of water to extract the medicinal residue for 2 hours, filter the extract, and use the filtrate for later use; , Pittosporum, Achyranthes bidentata, and Clematis add 12 times the amount of 60% ethanol, heat and reflux for extraction twice (1.5 hours / time), combine the extracts, filter, recover ethanol, merge with the above-mentioned water extraction part filtrate, and concentrate It is an extract with a relative density of 1.20-1.25 (50°C);

[003...

Embodiment 3

[0036] The preparation of embodiment 3 Chinese medicine composition gel

[0037] The traditional Chinese medicine composition of this example is made from the following raw materials: vinegar Corydalis 107.5g, Rhizoma Chuanxiong 86g, Clematis 86g, Fangfeng 107.5g, Zanthoxylum bungeanum 107.5g, Achyranthes bidentata 86g, Shenjincao 107.5g, Northeast Speranium 107.5g .

[0038]Pepper, Chuanxiong, and Fangfeng steam distillation to extract volatile oil for 8 hours, collect volatile oil; add 15 times the amount of water to extract the medicinal residue for 1.5 hours, filter the extract, and reserve the filtrate; , Pittosporum, Achyranthes bidentata, and Clematis add 12 times the amount of 70% ethanol, heat and reflux for extraction twice (2 hours / time), combine the extracts, filter, recover ethanol, merge with the above-mentioned water extraction part filtrate, and concentrate It is an extract with a relative density of 1.20-1.30 (50°C);

[0039] Dissolve carbomer in an appropri...

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Abstract

The invention provides an application of a traditional Chinese medicine composition in the preparation of medicines for treating psoriasis, characterized in that the traditional Chinese medicine composition comprises raw materials in the following proportions by weight: 20-200 parts of vinegar Corydalis, 10-160 parts of Rhizoma Chuanxiong 10‑160 parts of Clematis, 20‑200 parts of Fangfeng, 20‑200 parts of Zanthoxylum bungeanum, 10‑160 parts of Achyranthes bidentata, 20‑200 parts of Shenjincao, 20‑200 parts of Northeast Sperantophyllum, 10 parts of Passepartout ‑160 parts, 20‑200 parts of pituitary bark, 1‑10 parts of menthol, 2‑15 parts of borneol. The invention uses propranolol to cause guinea pig psoriasis model, and studies the influence of traditional Chinese medicine composition on guinea pig psoriasis. Experimental results show that the traditional Chinese medicine composition proposed by the invention has a good protective effect on guinea pig experimental psoriasis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis is a common and recurrent chronic inflammatory skin disease with clinical manifestations of erythema, papules, and scales. The domestic prevalence rate is about 0.47%, and the worldwide prevalence rate is 0.09%-11.43%, and it has an increasing trend year by year. Psoriasis is prone to occur or aggravate in spring and winter, and it is more relieved in summer and autumn. It has a long course of disease and is prone to relapse, and most patients often suffer from it for the rest of their lives, which causes great misery to the patients. The etiology of psoriasis is still not very clear, and it is believed that it is mainly related to factors such as heredity, infection, immune abnormality, endocrine, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61K9/06A61P17/06A61K31/045
CPCA61K36/66A61K36/236A61K36/716A61K36/238A61K36/758A61K36/21A61K36/12A61K36/47A61K36/185A61K36/48A61K31/045A61K9/06A61K47/18A61K9/0014A61P17/06A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 肖伟周恩丽孙晓萍王永香王星星王振中
Owner JIANGSU KANION PHARMA CO LTD