Polyethylene glycol polymer containing thioester and aldehyde group, preparation method of polyethylene glycol polymer, chemical cross-linked hydrogel containing polyethylene glycol polymer and application of chemical cross-linked hydrogel
A polyethylene glycol and polymer technology, applied in application, medical science, pharmaceutical formulation, etc., can solve problems such as inapplicability to body surface wounds, avoid falling and oxidation, and improve stability.
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Embodiment 1
[0067] A kind of preparation method that contains the polyethylene glycol polymer of thioester and aldehyde group, comprises the following steps:
[0068] I. Under an argon atmosphere, first add linear polyethylene glycol PEG2000 and succinic anhydride SA with a molar ratio of 1:3 into a 250mL eggplant-shaped bottle, then add 40mL of anhydrous dichloromethane, and stir until completely dissolved; then Weigh the catalyst 4-dimethylaminopyridine DMAP, wherein the molar ratio of DMAP to PEG2000 is 2:1, dissolve it in 10 mL of anhydrous dichloromethane, slowly inject it into the above reaction system through a micro-injection pump, and react in an ice-water bath for 4 hours , and then the ice-water bath was removed, and the reaction was continued for 24 h at room temperature. After the reaction was completed, most of the dichloromethane was removed by rotary evaporation, and 150 mL of deionized water was added, stirred evenly, and the pH was adjusted to about 3 with hydrochloric a...
Embodiment 2
[0072] A kind of preparation method that contains the polyethylene glycol polymer of thioester and aldehyde group, comprises the following steps:
[0073] I. Under argon atmosphere, first add four-arm polyethylene glycol PEG4000 and succinic anhydride SA with a molar ratio of 1:6 into a 250mL eggplant-shaped bottle, add 40mL of anhydrous dichloromethane, and stir until completely dissolved; Then the catalyst 4-dimethylaminopyridine DMAP was weighed, wherein the molar ratio of DMAP to PEG4000 was 4:1, dissolved in 10 mL of anhydrous dichloromethane, slowly injected into the above reaction system through a micro-injection pump, and placed in an ice-water bath After 4 hours of reaction, the ice-water bath was removed, and the reaction was continued for 24 hours at room temperature. After the reaction was completed, most of the dichloromethane was removed by rotary evaporation, and 150 mL of deionized water was added, stirred evenly, and the pH was adjusted to about 3 with hydroch...
Embodiment 3
[0077] A kind of preparation method that contains the polyethylene glycol polymer of thioester and aldehyde group, comprises the following steps:
[0078] I. Under argon atmosphere, first add six-arm polyethylene glycol PEG5500 and succinic anhydride SA with a molar ratio of 1:9 into a 250mL eggplant-shaped bottle, add 40mL of anhydrous dichloromethane, and stir until completely dissolved; Then the catalyst 4-dimethylaminopyridine DMAP was weighed, wherein the molar ratio of DMAP to PEG5500 was 6:1, dissolved in 10 mL of anhydrous dichloromethane, and slowly injected into the above reaction system through a micro-injection pump. After 4 hours of reaction, the ice-water bath was removed, and the reaction was continued for 24 hours at room temperature. After the reaction was completed, most of the dichloromethane was removed by rotary evaporation, and 150 mL of deionized water was added, stirred evenly, and the pH was adjusted to about 3 with hydrochloric acid; a large amount of...
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