Antibacterial peptide nano ointment, preparation method and application thereof

A kind of antimicrobial peptide and nanotechnology, which is applied in the field of ointment research, can solve the problems of antimicrobial peptide digestion and degradation, and achieve the effects of reducing irritation, increasing greasy feeling, biocompatibility and stability

Active Publication Date: 2020-08-07
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally composed of 12-50 amino acids, it has various biological functions such as antibacterial, antiviral, antiparasitic, anticancer, etc. It is conside

Method used

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  • Antibacterial peptide nano ointment, preparation method and application thereof
  • Antibacterial peptide nano ointment, preparation method and application thereof
  • Antibacterial peptide nano ointment, preparation method and application thereof

Examples

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Example Embodiment

[0039] Example 1:

[0040] An antibacterial peptide nano ointment, comprising antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and sodium lauryl sulfate; the antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and dodecane The mass ratio of sodium sulphate is 1:10:30:12:1.

[0041] The antimicrobial peptide nanocomposite is composed of phospholipid polymer nanoparticles circumscribed with antimicrobial peptides.

[0042] The phospholipid polymer nanoparticles include ICG, soybean lecithin, distearoylphosphatidylethanolamine-polyethylene glycol-NH 2 And PLGA.

[0043] The antimicrobial peptide is melittin MPX.

[0044] Further, a preparation method of antimicrobial peptide nano ointment includes the following steps:

[0045] S1: Use ICG, soybean lecithin, distearoylphosphatidylethanolamine-polyethylene glycol-NH 2 And PLGA to prepare phospholipid polymer nanoparticles;

[0046] Specifically, S11: ICG, soybean lec...

Example Embodiment

[0058] Example 2:

[0059] An antibacterial peptide nano ointment, comprising antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and sodium lauryl sulfate; the antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and dodecane The mass ratio of sodium sulphate is 1:10:30:10:3.

[0060] The antimicrobial peptide nanocomposite is composed of phospholipid polymer nanoparticles circumscribed with antimicrobial peptides.

[0061] The phospholipid polymer nanoparticles include ICG, soybean lecithin, distearoylphosphatidylethanolamine-polyethylene glycol-NH 2 And PLGA.

[0062] The antimicrobial peptide is melittin MPX.

[0063] In the preparation method of Example 2 antimicrobial peptide nano ointment, except that the mass ratio of antimicrobial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and sodium lauryl sulfate is different from that of Example 1, other operations are the same.

Example Embodiment

[0064] Example 3:

[0065] An antibacterial peptide nano ointment, comprising antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and sodium lauryl sulfate; the antibacterial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and dodecane The mass ratio of sodium sulphate is 1:20:20:12:1.

[0066] The antimicrobial peptide nanocomposite is composed of phospholipid polymer nanoparticles circumscribed with antimicrobial peptides.

[0067] The phospholipid polymer nanoparticles include ICG, soybean lecithin, distearoylphosphatidylethanolamine-polyethylene glycol-NH 2 And PLGA.

[0068] The antimicrobial peptide is melittin MPX.

[0069] In the preparation method of Example 3 antimicrobial peptide nano ointment, except that the mass ratio of antimicrobial peptide nanocomposite, stearyl alcohol, white petrolatum, propylene glycol and sodium lauryl sulfate is different from that of Example 1, other operations are the same.

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Abstract

The invention discloses an antibacterial peptide nano ointment, a preparation method and application thereof. The ointment is prepared from the following main components: an antibacterial peptide nanocompound, stearyl alcohol, albolene, propylene glycol and lauryl sodium sulfate, and is prepared by: externally connecting antibacterial peptide to phospholipid polymer nanoparticles and then mixingthe obtained product with stearyl alcohol, albolene, propylene glycol and lauryl sodium sulfate. After the phospholipid polymer nanoparticles are connected to the antibacterial peptide, part of antibacterial activity of the antibacterial peptide can be reserved, and some gram-positive bacteria and gram-negative bacteria can be inhibited and killed. The ointment disclosed by the invention can be used for treating skin diseases caused by staphylococcus aureus, pseudomonas aeruginosa and escherichia coli infection; the nano drug-loaded emulsifiable paste has good biocompatibility and stability, has long residence time after local administration, has slow-release and controlled-release effects on drug release, provides a new research field for researching novel antibacterial drugs, and has important theoretical and practical significance for improving the safety of human and animal products.

Description

technical field [0001] The invention relates to the technical field of ointment research, in particular to an antimicrobial peptide nano ointment and its preparation method and application. Background technique [0002] Long-term irrational use of antibiotics leads to adverse results such as bacterial resistance and antibiotic residues, which seriously endangers human health and the healthy development of animal husbandry. Therefore, there is an urgent need to find new alternatives to antibiotics. [0003] Antimicrobial peptides are a class of small molecule active polypeptides encoded by host genes, which can resist the invasion of pathogenic microorganisms and are an important part of the innate immune system. Generally composed of 12-50 amino acids, it has various biological functions such as anti-bacteria, anti-virus, anti-parasite, anti-cancer, etc. It is considered to be one of the best substitutes for antibiotics, but a single antibacterial peptide is easily absorbed...

Claims

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Application Information

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IPC IPC(8): A61K38/10A61K9/06A61K47/06A61K47/10A61K47/59A61K47/69A61P17/00A61P31/04
CPCA61K38/10A61K9/06A61K9/0014A61K47/06A61K47/10A61K47/59A61K47/6935A61P17/00A61P31/04Y02A50/30
Inventor 王磊刘善芹赵雪芹夏小静张守平赵娅娅徐彦召孙亚伟杭柏林王彦华白跃宇胡建和
Owner HENAN INST OF SCI & TECH
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