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Botanical ecdysone used for preventing muscle strength loss during fixation

An ecdysone, plant-based technology, applied in the field of plant-derived ecdysone and its derivatives for preventing muscle loss during fixation, can solve problems such as difficulty in large-scale introduction of procedures and intractable muscle areas to be stimulated.

Pending Publication Date: 2020-11-17
BIOPHYTIS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These programs have the disadvantage of being difficult to introduce on a large scale
Also, in some surgical patients where movement shows pain, using these methods is tricky, or even impossible
[0028] Studies of electrical myocardium stimulation have also been performed, but this method was not able to produce systemic beneficial stimulation, said method may show ineffectiveness in patients exhibiting sarcolemmal atexcitability, and in the case of prolonged immobilization, The choice of muscle area to be stimulated is tricky

Method used

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  • Botanical ecdysone used for preventing muscle strength loss during fixation
  • Botanical ecdysone used for preventing muscle strength loss during fixation
  • Botanical ecdysone used for preventing muscle strength loss during fixation

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Experimental program
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Embodiment Construction

[0088] The method for synthesizing formula (II) compound

[0089] The compounds of formula (II) cited in the remainder of the specification are as follows:

[0090]

[0091] The compound of formula (II) is obtained by semi-synthesis from 20-hydroxyecdysone and subsequent purification to pharmaceutical grade.

[0092] Processes for the preparation of compounds of formula (II) by semi-synthesis include in particular:

[0093] - a step of oxidative cleavage of the side chain of 20-hydroxyecdysone between carbons C20 and C22 in order to obtain poststerone,

[0094] - the step of introducing a bromine atom at position C21, and

[0095] - a step of reacting a bromine derivative with ethanethiol.

[0096] Biological activity of compounds of formula (II)

[0097] The immobilization model of the hind paw of genetic background C57BL / 6J mice was implemented by tube (Lang et al., 2012).

[0098] Female C57BL / 6J mice aged 13 weeks were used. Ten mice were sacrificed at J0 and ...

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Abstract

The invention concerns a composition comprising at least one phytoecdysone or at least one semi-synthetic derivative of a phytoecdysone, for use in mammals for preventing the loss of muscle strength during immobilisation. More particularly, the invention concerns a composition for use that comprises 20-hydroxyecdysone or a semi-synthetic derivative of 20-hydroxyecdysone. Moreover, the invention concerns a composition for use that comprises a compound of general formula (I).

Description

technical field [0001] The present invention relates to the use of phytoecdysone and its derivatives for preventing loss of muscle strength during immobilization. Background technique [0002] There is a high risk of complications following immobilization of limbs or prolonged maintenance of a recumbent position (décubitus) and may manifest as troubles musculaires, as well as bronchopulmonary, cardiovascular or osteoarticular problems (Bodine 2013 , Hermans & Van den Berghe 2015; De Jonghe et al. 2007; Wentworth et al. 2017; Iordens et al. 2017). [0003] Immobilization can be gradual or sudden, and in the most extreme cases can involve a limb or extend throughout the body. There are many situations that lead to pinning, such as: [0004] - Fracture or injury of an extremity which results in an external fixation device (collar or sling type non-plaster support, immobilization bandage, metal or knee brace, syndactylie in case of complete or incomplete immobilization of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P21/06
CPCA61K31/575A61P21/06A61K9/0053A61K31/57
Inventor 皮埃尔·迪尔达玛蒂尔德·拉蒂伊勒内·拉丰斯坦尼斯拉斯·韦耶
Owner BIOPHYTIS