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External pharmaceutical composition for clearing damp toxin and stasis and preparation method

A technology for external use of medicines and compositions, applied in the field of skin disease treatment, can solve the problems of aggravated itching, many contraindications, dependence and the like

Inactive Publication Date: 2020-12-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have many contraindications and can easily cause side effects such as drowsiness and fatigue. Long-term use of hormone ointments can easily lead to dependence, and may also cause aggravated itching after drug withdrawal

Method used

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  • External pharmaceutical composition for clearing damp toxin and stasis and preparation method
  • External pharmaceutical composition for clearing damp toxin and stasis and preparation method
  • External pharmaceutical composition for clearing damp toxin and stasis and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 emulsion type ointment

[0018] 1. Accurately weigh 80 parts of road snake, 60 parts of bitter plum root, 30 parts of rhubarb, 30 parts of coptis, 30 parts of Phellodendron phellodendri, 40 parts of Angelica dahurica, 40 parts of Burnet, 20 parts of methyl salicylate, and menthol according to the prescription quantity 40 parts, borneol 20 parts, camellia oil 200 parts, spare;

[0019] 2. Soak road snake, bitter plum root, rhubarb, coptis, Phellodendron, Angelica dahurica, and Burnet with 70% ethanol that is 10 times the weight of medicinal materials, filter, and depressurize the filtrate to recover ethanol until it has no alcohol smell, add 100 parts of propylene glycol, three 30 parts of ethanolamine, stir evenly, keep warm at 80°C to obtain liquid A, set aside;

[0020] 3. Heat camellia oil, 100 parts of stearic acid, 100 parts of paraffin, 50 parts of vaseline, and 40 parts of glyceryl monostearate to melt at 80°C, stir evenly to obtain liquid B, and se...

Embodiment 2

[0022] Embodiment 2 greasy ointment

[0023] 1. Accurately weigh 80 parts of road snake, 60 parts of bitter plum root, 30 parts of rhubarb, 30 parts of coptis, 30 parts of Phellodendron phellodendri, 40 parts of Angelica dahurica, 40 parts of Burnet, 20 parts of methyl salicylate, and menthol according to the prescription quantity 40 parts, borneol 20 parts, camellia oil 200 parts, spare;

[0024] 2. Soak road snake, bitter plum root, rhubarb, coptis, Phellodendron, Angelica dahurica, and Burnet with 70% ethanol overnight, filter, and depressurize the filtrate to recover ethanol until it has no alcohol smell. Add camellia oil and vaseline at 80°C to keep warm 100 parts, 100 parts of paraffin, stir evenly, take out and cool to 40°C, add methyl salicylate, menthol, borneol, stir evenly, let cool to room temperature, pack separately, and obtain.

Embodiment 3

[0025] Embodiment 3 water-soluble ointment

[0026] 1. Accurately weigh 80 parts of road snake, 60 parts of bitter plum root, 30 parts of rhubarb, 30 parts of coptis, 30 parts of Phellodendron phellodendri, 40 parts of Angelica dahurica, 40 parts of Burnet, 20 parts of methyl salicylate, and menthol according to the prescription quantity 40 parts, 20 parts borneol, spare;

[0027] 2. Soak road snake, bitter plum root, rhubarb, coptis, Phellodendron phellodendron, Angelica dahurica, and Burnet with 70% ethanol overnight, filter, decompress and recover ethanol from the filtrate until it has no alcohol smell, and obtain liquid A for later use;

[0028] 3. Take 50 parts of sodium carboxymethyl cellulose, add 100 parts of glycerin and 5 parts of sodium benzoate, and grind evenly. After the sodium carboxymethyl cellulose is fully expanded, add liquid A, stir evenly, and make up to 1000 parts with purified water. Portion, sub-package, that is to say.

[0029] Pharmacological effica...

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Abstract

The invention discloses an external pharmaceutical composition for clearing damp toxin and stasis. The external pharmaceutical composition consists of the following raw medicinal materials: herba polygoni perfoliati, radix rhamni crenatae, radix et rhizoma rhei, rhizoma coptidis, cortex phellodendri, radix angelicae and radix sanguisorbae. The composition is supplemented with herba menthae, camellia oil and the like to prepare an external ointment. Researches show that the external ointment disclosed by the invention has the effects of killing bacteria, relieving itching, resisting inflammation and easing pain, can be used for treating various skin itches to achieve the purpose of inhibiting itches, and has no irritation and no toxic and side effects. In addition, the external pharmaceutical composition is convenient to use, simple in process and exact in curative effect, and opens up a new way for developing traditional ethnic medicine.

Description

technical field [0001] The invention belongs to the technical field of skin disease treatment, and in particular relates to an external pharmaceutical composition for removing dampness, toxin and blood stasis and a preparation method thereof. Background technique [0002] Pruritus is a common and multiple disease in dermatology. When the patient has itchy skin, he will show inattention, upset, and restlessness, which seriously affects the daily work and life of the patient. Patients often scratch with their hands and develop secondary skin lesions. Scratch marks and blood stasis may occur due to excessive scratching, and symptoms such as eczema, lichenification, and pigmentation may also appear over time. At present, the cause of skin itching is still unclear, and it is mostly believed to be related to certain diseases, such as diabetes, hepatitis, kidney disease, etc.; at the same time, it is also related to some external stimuli, such as dry cold, damp heat, chemical fib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61K47/44A61P17/00
CPCA61K9/0014A61K9/06A61K36/232A61K36/28A61K36/708A61K36/718A61K36/72A61K36/739A61K36/756A61K47/44A61P17/00A61K2300/00
Inventor 冯秋瑜黄慧学梁秋云覃文慧
Owner GUANGXI UNIV OF CHINESE MEDICINE