Adriamycin corn starch grafted polymer micelle and preparation method thereof
A technology of grafted polymer and corn starch, which is applied in the field of biomedicine to achieve the effects of low manufacturing cost, good biocompatibility and stable process
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Embodiment 1
[0022] Embodiment 1: the synthesis of cornstarch graft polymer
[0023] S1. Synthesis of zwitterionic starch grafted polymer: Dissolve 1 mmol of corn starch in 3 mL of ultrapure water, add 3 mL of 40 wt % sodium hydroxide solution dropwise to it, and stir and react at 40 ° C for 0.5 h to obtain Alkalized starch suspension: Dissolve 0.2g sulfobetaine in 20mL water, add to the above-mentioned alkalized starch suspension, stir and react at 40°C for 0.5h; neutralize the reaction system to neutral with glacial acetic acid, Precipitate with methanol, obtain precipitate after centrifugation, and freeze-dry to obtain zwitterionic starch graft polymer;
[0024] S2. Synthesis of corn starch graft polymer: 1.2mmol 1-ethyl-(3-dimethylaminopropyl)-carbodiimide hydrochloride, 0.6mmol N-hydroxysuccinimide and 0.1mmol deoxygenated Cholic acid was dissolved in 5mL N,N-dimethylformamide, and activated at room temperature for 15min to obtain carboxyl-activated deoxycholic acid; 200mg of zwitter...
Embodiment 2
[0026] Embodiment 2: the synthesis of corn starch graft polymer
[0027] S1. Synthesis of zwitterionic starch grafted polymer: Dissolve 1 mmol of corn starch in 3 mL of ultrapure water, add 3 mL of 40 wt % sodium hydroxide solution dropwise to it, and stir and react at 50 ° C for 1 h to obtain alkali starch suspension; 0.4g sulfobetaine was dissolved in 3mL water, and added to the above alkalized starch suspension, stirred and reacted at 60°C for 5h; the reaction system was neutralized to neutral with glacial acetic acid, and methanol precipitated analysis, centrifugation to obtain a precipitate, and freeze-drying to obtain a zwitterionic starch grafted polymer;
[0028] S2. Synthesis of corn starch graft polymer: 1.2mmol 1-ethyl-(3-dimethylaminopropyl)-carbodiimide hydrochloride, 0.6mmol N-hydroxyl succinimide and 0.3mmol deoxygenated Cholic acid was dissolved in 5mL N,N-dimethylformamide, and activated at room temperature for 20min to obtain carboxyl-activated deoxycholic a...
Embodiment 3
[0030] Embodiment 3: the synthesis of cornstarch graft polymer
[0031] S1. Synthesis of zwitterionic starch grafted polymer: Dissolve 1 mmol of corn starch in 3 mL of ultrapure water, add 3 mL of 40 wt % sodium hydroxide solution dropwise to it, and stir and react at 70 ° C for 1.5 h to obtain Alkalized starch suspension; dissolve 1.6g sulfobetaine in 3mL water, and add it to the above-mentioned alkalized starch suspension, stir and react at 70°C for 8h; neutralize the reaction system with glacial acetic acid, then methanol Precipitation treatment, centrifugation to obtain a precipitate, freeze-drying to obtain a zwitterionic starch graft polymer;
[0032]S2. Synthesis of corn starch grafted polymer: 1.2mmol 1-ethyl-(3-dimethylaminopropyl)-carbodiimide hydrochloride, 0.6mmol N-hydroxysuccinimide and 1mmol deoxychol The acid was dissolved in 5mL N,N-dimethylformamide, and activated at room temperature for 30min to obtain carboxyl-activated deoxycholic acid; 200mg of zwitterio...
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