Preparation method of nitenpyram sustained-release tablets

A technology for nitenpyram and sustained-release tablets, which is applied in the field of preparation of nitenpyram sustained-release tablets, can solve the problems of special preparation equipment, high preparation equipment requirements, slow preparation process, etc., and achieves good drug stability, The effect of good color and large drug loading

Inactive Publication Date: 2021-01-01
安徽省公众检验研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the double-layer tablet prepared by this method can control the release of the drug to a certain extent, the preparation process is complicated and the requirements for the preparation equipment are relatively high.
[0006] Therefore, there is a need to provide a preparation technol

Method used

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  • Preparation method of nitenpyram sustained-release tablets
  • Preparation method of nitenpyram sustained-release tablets
  • Preparation method of nitenpyram sustained-release tablets

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033]Example 1

[0034]

[0035]The preparation method includes the following steps:

[0036](1) Preparation of tablet core: Mix nitenpyram and PVP K-90, add penetrant, sieving, dry at 50°C, add sodium lauryl sulfate, lactose, starch, and press to obtain nitenpyram Amine core

[0037](2) Preparation of coating solution: add magnesium stearate, talc, and titanium dioxide to the water in order to prepare an aqueous dispersion, and add hypromellose and polyethylene glycol 4000 to the aqueous dispersion; prepare a coating liquid;

[0038](3) Place the nitenpyram tablet core in a coating solution at 30°C for coating treatment, and then dry at 50°C to obtain the nitenpyram sustained-release tablet.

[0039]As mentioned above, the penetrant is a mixture of azone lauryl, sodium chloride and glycerin, and the mass ratio of the azone lauryl, sodium chloride and glycerol is 4:1:10.

[0040]As mentioned above, the mass ratio of hydroxypropyl cellulose to polyethylene glycol 4000 in the coating liquid is 3:1.

Example Embodiment

[0041]Example 2

[0042]

[0043]The preparation method includes the following steps:

[0044](1) Preparation of tablet core: Mix nitenpyram and PVP K-90, add penetrant, sieving, dry at 50°C, add sodium lauryl sulfate, lactose, starch, and press to obtain nitenpyram Amine core

[0045](2) Preparation of coating solution: add magnesium stearate, talc, and titanium dioxide to the water in order to prepare an aqueous dispersion, and add hypromellose and polyethylene glycol 4000 to the aqueous dispersion; prepare a coating liquid;

[0046](3) Place the nitenpyram tablet core in a coating solution at 30°C for coating treatment, and then dry at 50°C to obtain the nitenpyram sustained-release tablet.

[0047]As mentioned above, the penetrating agent is a mixture of azone lauryl, sodium chloride and glycerin, and the mass ratio of azone lauryl, sodium chloride and glycerol is 3:2:12.

[0048]As mentioned above, the mass ratio of hydroxypropylcellulose to polyethylene glycol 4000 in the coating liquid is 4:1.

Example Embodiment

[0049]Example 3

[0050]

[0051]The preparation method includes the following steps:

[0052](1) Preparation of tablet core: Mix nitenpyram and PVP K-90, add penetrant, sieving, dry at 50°C, add sodium lauryl sulfate, lactose, starch, and press to obtain nitenpyram Amine core

[0053](2) Preparation of coating solution: add magnesium stearate, talc, and titanium dioxide to the water in order to prepare an aqueous dispersion, and add hypromellose and polyethylene glycol 4000 to the aqueous dispersion; prepare a coating liquid;

[0054](3) Place the nitenpyram tablet core in a coating solution at 30°C for coating treatment, and then dry at 50°C to obtain the nitenpyram sustained-release tablet.

[0055]As mentioned above, the penetrant is a mixture of azone lauryl, sodium chloride and glycerin, and the mass ratio of the azone lauryl, sodium chloride and glycerol is 5:1:10.

[0056]As mentioned above, the mass ratio of hydroxypropyl cellulose to polyethylene glycol 4000 in the coating liquid is 5:1.

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Abstract

The invention discloses a preparation method of nitenpyram sustained-release tablets, and the nitenpyram sustained-release tablets are prepared from a tablet core and a coating, the tablet core is prepared from nitenpyram, PVP -90 and a penetrant. The nitenpyram sustained-release tablets prepared according to the invention has stable drug release speed and high drug loading capacity, which can take effect quickly and maintain effective blood concentration for a long time,can be achieved quickly, the effective blood concentration can be maintained for a long time, and the stability is good;cantake effect quickly, and can maintain effective blood drug concentration for a long time, and has good stability. The preparation method is simple and easy to popularize application.

Description

technical field [0001] The invention relates to the technical field of anti-parasitic veterinary drugs, in particular to a preparation method of nitenpyram sustained-release tablets. Background technique [0002] Nitenpyram (Nitenpyram), the chemical name is (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitroethylenediamine, CAS No. 150824-47-8, it is a nicotinimide insecticide developed by Takeda Corporation of Japan in 1989. It has the advantages of small harm to animals and safe use. , In 2000, Eli Lilly (Elanco US Inc.) launched Nitenpyram tablets (trade name Capstar) in the United States for the treatment of fleas on dogs and cats, and the tablets were registered in China in 2013. [0003] Nitenpyram can act on the flea's nervous system, interfere with the flea's nerve conduction electrical signal, and cause the flea to be in a state of excitement for a long time and eventually die. Take nitenpyram tablets orally for dogs or cats, it will start to work after 1...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/38A61K47/10A61K47/36A61K47/22A61K47/02A61K31/44A61P33/14
CPCA61K9/2009A61K9/2013A61K9/2059A61K9/2813A61K9/2853A61K9/2866A61K31/44A61P33/14
Inventor 童成亮袁东婕刘舜舜蔡学佳邓萍
Owner 安徽省公众检验研究院有限公司
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