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A synergistic bactericidal and antibacterial ethylhexylglycerin composition

A technology of ethylhexylglycerin and synergistic effect, which is applied in the field of daily chemical industry to achieve the effect of synergistic antiseptic performance and improved efficacy

Active Publication Date: 2022-04-29
NANJING HUASHI NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, because the mechanism of action is to interfere with the external environment on which microorganisms depend, it is also extremely unlikely to produce drug resistance.

Method used

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  • A synergistic bactericidal and antibacterial ethylhexylglycerin composition
  • A synergistic bactericidal and antibacterial ethylhexylglycerin composition
  • A synergistic bactericidal and antibacterial ethylhexylglycerin composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: Escherichia coli ATCC8739

[0046] 1. In a 96-well plate, the two components are added at different concentrations, and the antibacterial results against Escherichia coli are shown as follows: Figure 2A . The gray scale circle in the figure indicates that it is still a turbid liquid after adding components, indicating that there is no antibacterial ability. The blank circles in the figure indicate that after adding components, the additives have effectively inhibited the growth of bacteria, and the bacterial suspension changed from turbid to clear.

[0047] 2. Partial inhibition index FICI calculation and calculation of the ratio of the two components added.

[0048] A component = Evermild TM EHG (MIC A ) Concentration calculation unit ppm (ug / ml),

[0049] B component = Evermild TM GLDA-30 (MIC B ) Concentration is calculated in ppm (ug / ml).

[0050] Calculated on the basis of 100% active matter, the calculation results are shown in Table 2 below...

Embodiment 2

[0061] Example 2: Pseudomonas aeruginosa ATCC 9027

[0062] In a 96-well plate, the two components were added at different concentrations, and the antibacterial results against Pseudomonas aeruginosa showed as follows Figure 3A . The gray scale circle in the figure indicates that it is still a turbid liquid after adding components, indicating that there is no antibacterial ability. The blank circles in the figure indicate that after adding components, the additives have effectively inhibited the growth of bacteria, and the bacterial suspension changed from turbid to clear.

[0063] 1. Calculation of partial inhibition index FICI and calculation of the ratio of the two components added.

[0064] A component = Evermild TM EHG (MIC A ) Concentration calculation unit ppm (ug / ml),

[0065] B component = Evermild TM GLDA-30 (MIC B ) Concentration is calculated in ppm (ug / ml). Calculated on the basis of 100% active matter, the calculation results are shown in Table 3 below. ...

Embodiment 3

[0076] Example 3: Staphylococcus aureus ATCC 6538

[0077] 1. In a 96-well plate, the two components are added at different concentrations, and the antibacterial results against Staphylococcus aureus are shown as follows: Figure 4A . The gray scale circle in the figure indicates that it is still a turbid liquid after adding components, indicating that there is no antibacterial ability. The blank circles in the figure indicate that after adding components, the additives have effectively inhibited the growth of bacteria, and the bacterial suspension changed from turbid to clear.

[0078] 2. Partial inhibition index FICI calculation and calculation of the ratio of the two components added.

[0079] A component = Evermild TM EHG (MIC A ) Concentration calculation unit ppm (ug / ml),

[0080] B component = Evermild TM GLDA-30 (MIC B ) Concentration is calculated in ppm (ug / ml).

[0081] Calculated on the basis of 100% active matter, the calculation results are shown in Table...

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Abstract

The invention discloses a synergistic bactericidal and antibacterial ethylhexylglycerin composition, which is characterized in that the composition contains ethylhexylglycerin and an amino acid chelating agent, and the ratio is 1:64 based on mass concentration to 1:0.25; the amino acid chelating agent has the following structure, wherein, R is CH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 2 CH 2 CH 2 CH 2 , CH 2 CH 2 CH 2 CH 2 CH 2 , CH 2 OCH 2 or CH 2 CH 2 OCH 2 CH 2 ; 1 , R 2 for CH 2 CH 2 or CH 2 CH 2 CH 2 . The composition can greatly improve the efficacy of the compositions, and exert synergistic bactericidal and antibacterial properties.

Description

technical field [0001] The invention belongs to the technical field of daily chemical industry, and relates to an antibacterial composition, in particular to a synergistic bactericidal and antibacterial ethylhexylglycerin composition, which contains ethylhexylglycerin and an amino acid chelating agent, and exhibits a synergistic effect Bactericidal and antibacterial effect. Background technique [0002] One trend affecting the global cosmetics industry is the increasing demand for natural and sustainable products and ingredients. The same is true for safe, effective and green anti-corrosion systems. Meeting the demand for mild green preservatives while ensuring the efficacy and broad-spectrum antibacterial properties of preservatives is a severe challenge for preservatives. [0003] At present, traditional preservatives are mainly chemical synthesis. Much debated for its safety and stimulant properties with long-term use. The most commonly used traditional preservatives ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/44A61K8/34A61Q19/00
CPCA61K8/44A61K8/345A61Q19/00A61K2800/592A61K2800/524A61K2800/10
Inventor 任传鹏公平苏桂珍
Owner NANJING HUASHI NEW MATERIAL CO LTD