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Dynamic angiographic imaging

A technique of angiography and blood vessels, which is applied in the field of evaluating blood vessels in subjects, and can solve the problems of reduced accuracy of FFR-CT measurement

Pending Publication Date: 2021-02-26
LONDON HEALTH SCI CENT RES
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

A recent systematic review has revealed that the diagnostic accuracy of computed tomography-derived fractional flow reserve when compared with the gold standard catheter-based FFR measurement (Cook et al., (2017), Systematic Reviews, JAMA; 2(7) :803-810), the accuracy of FFR-CT measurements decreases with increasing stenosis

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Embodiment Construction

[0042] Referring to the figures, a system and method for dynamic angiographic imaging (DAI) is described. The system and method compare favorably with current CCTA technology.

[0043] figure 1An example of a computer-implemented imaging system, more specifically a DAI system 2, incorporating a computed tomography (CT) scanner 4 is shown. CT scanner 4 may be any multi-slice or multi-slice CT scanner, which generally includes a radiation source, radiation detectors, and optional controls for maintaining the subject in a desired position (e.g., a prone or prone position) during the scanning procedure. An adjustable, usually motorized, support or table. A radiation source produces radiation that, in synchronization with the administration of a contrast agent (also known as a tracer) to a subject, traverses one or more predetermined sampling sites that target a region of interest within the subject. blood vessels. A radiation detector, often configured as a panel of rotating d...

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Abstract

Described herein is a computer implemented method for dynamic angiographic imaging comprising: obtaining image data comprising a plurality of corresponding images capturing at least a portion of bothan increase phase and a decline phase of a contrast agent in a blood vessel of interest; generating at least one time-enhancement curve of the contrast agent based on the image data; determining a blood flow characteristic in the blood vessel of interest based on the time- enhancement curve. Systems for implementing the method and computer readable media incorporating the method are also described.

Description

technical field [0001] The present invention relates to dynamic imaging of blood flow, and more particularly to assessing blood vessels in a subject based on dynamic imaging of contrast medium flow through the blood vessel. Background technique [0002] The clinical gold standard for assessing the functional importance of coronary artery stenosis is the invasive Fractional Flow Reserve (FFR) technique, in which a dedicated catheter is advanced into the culprit artery with the aid of fluoroscopy to measure plaque onset during periods of maximal hyperemia. blood pressure gradient. Recently, non-invasive assessment of FFR using CT coronary angiography (CCTA) images has emerged as a promising avenue for evaluating high-risk patients requiring anatomical and functional assessment for coronary artery disease (CAD). However, at present, FFR assessment by CCTA requires extensive post-processing and calculations (often exceeding several hours), and thus, is not currently suitable fo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B6/03G01N23/046G16H30/20G06T7/00G06K9/32G06T7/20
CPCA61B6/032A61B6/504A61B6/481A61B6/5217G16H30/20G16H30/40G16H20/40G16H50/50G16H50/30A61B5/0275A61B5/0263G01R33/5635G01R33/56308
Inventor 苏兆霖李延炎
Owner LONDON HEALTH SCI CENT RES