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A special intestinal delivery carrier for astronauts and preparation method thereof

A technology of intestines and carriers, applied in the field of nanomaterials, can solve the problems of intestinal malabsorption of microgravity protective agents, and achieve the effects of improving bioavailability, mild conditions, and good adhesion

Active Publication Date: 2022-07-12
CHINA WEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of intestinal malabsorption of microgravity protective agents that occur during astronauts' space flight, the present invention provides an intestinal delivery carrier, which is a self-assembled nano Granules, the weight ratio of the polylysine and tremella polysaccharide is 1:6~1:10

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of enteral delivery vehicle of the present invention

[0031] The aqueous solution of poly-ε-L-lysine (pH8.0) and the PBS solution of anionic tremella polysaccharide (pH8.0) were prepared respectively; the poly-ε-L-lysine solution was added to an equal volume of tremella polysaccharide solution , the concentration ratio of poly-ε-L-lysine and anionic Tremella polysaccharide in the solution is 1:7. Stir (the rotation speed is 60 rpm), centrifuge after 3 hours at room temperature, and the precipitate is the intestinal delivery carrier for astronauts' stomach. The particle size distribution of the carrier was 264-327 nm, and the PDI was 0.157±0.015.

Embodiment 2

[0032] Example 2 Preparation of enteral delivery vehicle of the present invention

[0033] The aqueous solution of poly-ε-L-lysine (pH8.0) and the PBS solution of anionic tremella polysaccharide (pH8.0) were prepared respectively; the poly-ε-L-lysine solution was added to an equal volume of tremella polysaccharide solution , the concentration ratio of poly-ε-L-lysine and anionic Tremella polysaccharide in the solution is 1:8. Stir (the rotation speed is 70 rpm), centrifuge after 3 hours at room temperature, and the precipitate is the intestinal delivery carrier for astronauts' stomach. The particle size distribution of the carrier was 240-309 nm, and the PDI was 0.153±0.008.

Embodiment 3

[0034] Example 3 Preparation of enteral delivery vehicle of the present invention

[0035] The aqueous solution of poly-ε-L-lysine (pH8.0) and the PBS solution of anionic tremella polysaccharide (pH8.0) were prepared respectively; the poly-ε-L-lysine solution was added to an equal volume of tremella polysaccharide solution , the concentration ratio of poly-ε-L-lysine and anionic Tremella polysaccharide in the solution is 1:9. Stir (the rotation speed is 80 rpm), centrifuge after 3 hours at room temperature, and the precipitate is the special intestinal delivery carrier for astronauts' stomach. The particle size distribution of this carrier is 207~299nm, and the PDI is 0.167±0.01.

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Abstract

The invention provides an intestinal delivery carrier for astronauts in space missions, which is a self-assembled nanoparticle prepared from polylysine and tremella polysaccharide. The weight of the polylysine and tremella polysaccharide is The ratio is 1:6 to 1:10. The present invention also provides the preparation method and use of the intestinal delivery carrier. The invention uses natural product extracted components as raw materials to prepare self-assembled nanoparticles with rough surface structure, narrow particle size distribution, good dispersibility, good intestinal adhesion under simulated microgravity, safety and effectiveness, and is suitable for aerospace It can be used by personnel for a long time during space flight missions, and the application prospect is good.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a special intestinal delivery carrier for astronauts and a preparation method thereof. Background technique [0002] The space environment will shorten the intestinal emptying time of the human body, coupled with the poor contact between the intestinal digesta and the intestinal mucosa caused by microgravity, which will weaken the intestinal absorption effect of the astronauts taking the microgravity protective agent, and eventually lead to a decrease in the efficacy or complete disappearance of the drug. . The application of rough surface intestinal carrier has become one of the ways to solve the problem of poor absorption or reduced effect of human microgravity protective agents in a microgravity environment. [0003] However, the current intestinal delivery carrier or carrier material is not ideal. Either organic reagents appear in the preparation process of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/34A61P1/00A23L33/125A23L33/18
CPCA61K47/36A61K47/34A61P1/00A23L33/125A23L33/18A23V2002/00A23V2200/32A23V2250/51A23V2250/55Y02A50/30
Inventor 刁岩杨在君王东微
Owner CHINA WEST NORMAL UNIVERSITY
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