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Rotary reactor for uniform particle coating with thin films

A technology of reactors and granules, applied in chemical methods for reacting gases with non-granular solids, details of chemical/physical/physicochemical reactors, coatings, etc., can solve the problem of insufficient prevention of API degradation and inability to expand Problems such as mass production, to achieve the effect of reducing drug prices, consistent properties, and low manufacturing costs

Pending Publication Date: 2021-03-23
APPLIED MATERIALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, ALD reactors are suitable for inorganic coatings but not for organic polymer coatings, and existing iCVD designs cannot adequately prevent API degradation and cannot be scaled up to high-volume manufacturing

Method used

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  • Rotary reactor for uniform particle coating with thin films
  • Rotary reactor for uniform particle coating with thin films
  • Rotary reactor for uniform particle coating with thin films

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Embodiment Construction

[0045] Various methods of encapsulating API particles exist. In many cases, these methods result in relatively thick coatings. While these coatings can impart desirable properties, the high ratio of coating to API can make it difficult to produce drug products with volume fractions of API as high as desired. Additionally, the coating that encapsulates the API can be non-uniform, making it difficult to provide formulations with consistent properties. Additionally, coating techniques that can provide satisfactory consistency are not scalable for industrial manufacturing.

[0046] A solution to these problems is the use of a rotating "drum", wherein the particles are centrifuged against the inner wall of the rotating drum via rotational motion of the drum in a first direction, and wherein particles are centrifuged against the inner wall of the rotating drum in a second direction (e.g., with The paddles rotating in the same or opposite direction as the first direction agitate th...

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Abstract

A reactor for coating particles includes one or more motors, a rotary vacuum chamber configured to hold particles to be coated, wherein the rotary vacuum chamber is coupled to the motors to rotate therotary vacuum chamber in a first direction about an axial axis of a cylindrical portion of the rotary vacuum chamber, a vacuum port to exhaust gas from the rotary vacuum chamber, a paddle assembly including a rotatable drive shaft extending through the rotary vacuum chamber and coupled to the one or more motors and at least one paddle extending radially from the drive shaft, such that rotation ofthe drive shaft by the motors orbits the paddle about the drive shaft in a second direction, and a chemical delivery system including a gas outlet on the paddle configured inject process gas into theparticles.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 683,763, filed June 12, 2018, the disclosure of which is incorporated herein by reference. technical field [0003] The present disclosure relates to the coating of particles, eg, particles comprising active pharmaceutical ingredients, by thin organic and inorganic films. Background technique [0004] The development of improved formulations of active pharmaceutical ingredients (active pharmaceutical ingredients (APIs) is of great interest to the pharmaceutical industry. Formulation can affect the stability and bioavailability, among other properties, of an API. Formulation can also affect various aspects of drug product (DP) manufacturing, eg, ease and safety of the manufacturing process. [0005] Numerous techniques have been developed for encapsulating or coating APIs. Some existing techniques for coating APIs include spray coating, pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C16/455C23C16/44C23C16/448C23C16/40A61K9/50
CPCC23C16/4417C23C16/442C23C16/45555C23C16/45544C23C16/45578B01J19/0066B01J19/006B01J3/006B01J3/02B01J4/007B01J3/03B01J15/00B01J19/1887C23C16/45548C23C16/45589C23C16/4412C23C16/4488C23C16/40A61K9/5089A61K9/501A61K9/5021
Inventor 科林·C·内科克普拉文·K·纳万克尔考沙尔·冈加什卡尔维斯韦斯瓦伦·西瓦拉玛克里施南乔纳森·弗兰克尔戴维·马萨尤基·石川夸克·特伦约瑟夫·尤多夫斯基
Owner APPLIED MATERIALS INC