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Compositions for the treatment of skin conditions

A composition, skin technology, applied in products or kits for skin disorders, in the field of sponges of the phylum Porophyta, which can solve problems such as exacerbation, difficulty in local treatment, and reduction in the ability of toxins to diffuse through the skin epithelium.

Pending Publication Date: 2021-03-30
DERMATA THERAPEUTICS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Two-thirds of affected individuals do not seek medical treatment because conventional treatments are often ineffective and social embarrassment is considerable
However, the difficulty of using products containing one or more botulinum toxins for the topical treatment of skin disorders in subjects is well known
One difficulty with topical use of botulinum toxin-containing products is the recognition of the endogenous non-toxin proteins in the botulinum toxin complex obtained from Clostridium botulinum (i.e., non-toxic hemagglutinin and non-toxic hemagglutinin protein) reduces the ability of toxins to diffuse through the skin epithelium
These effects are further exacerbated when exogenous stabilizers such as albumin are combined with botulinum toxin during routine production

Method used

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  • Compositions for the treatment of skin conditions
  • Compositions for the treatment of skin conditions
  • Compositions for the treatment of skin conditions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Example 1 :plan 1

[0192] Week 1: Subject's skin was washed and dried with a non-comedogenic cleanser. Will contain botulinum toxin (botulinum toxin type A, botulinum toxin type B, botulinum toxin type C1, botulinum toxin type C2, botulinum toxin type D, botulinum toxin type E, F botulinum toxin type G and botulinum toxin type G, onabotulinumtoxinA, abobotulinumtoxinA, incobotulinumtoxinA, prabotulinumtoxinA, daxibotulinumtoxinA, rimabotulinumtoxinB, EB-001A, or EB-001T) were reconstituted with 10 mL of 0.9% sterile saline and the reconstituted Set aside the solution. Three percent (3%) hydrogen peroxide USP 9 (6 mL) was added to 3 grams (dry weight) of the spongy spongy powder, and the resulting mixture was stirred until well mixed. The spongy spongy mixture was applied to the affected area of ​​the subject's skin, taking care to avoid mucous membranes (eg, eyes, mouth, and nostrils). Additional spongy material may be applied to areas of the subject's skin where ...

Embodiment 2

[0196] Week 1: Subject's skin was washed and dried with a non-comedogenic cleanser. Will contain botulinum toxin (botulinum toxin type A, botulinum toxin type B, botulinum toxin type C1, botulinum toxin type C2, botulinum toxin type D, botulinum toxin type E, F botulinum toxin type G and botulinum toxin type G, onabotulinumtoxinA, abobotulinumtoxinA, incobotulinumtoxinA, prabotulinumtoxinA, daxibotulinumtoxinA, rimabotulinumtoxinB, EB-001A, or EB-001T) were reconstituted with 10 mL of 0.9% sterile saline and the reconstituted Set aside the solution. Three percent (3%) hydrogen peroxide USP (6 mL) was added to 3 grams (dry weight) of the spongy spongy powder, and the resulting mixture was stirred to mix well. The reconstituted botulinum toxin composition is then applied to the affected area of ​​the subject's skin and the area where the spongy spongiosa composition was applied, taking care to avoid mucous membranes (eg, eyes, mouth, and nostrils). The spongy spongy mixture wa...

Embodiment 3

[0200] Week 1: Subject's skin was washed and dried with a non-comedogenic cleanser. Will contain botulinum toxin (botulinum toxin type A, botulinum toxin type B, botulinum toxin type C1, botulinum toxin type C2, botulinum toxin type D, botulinum toxin type E, F botulinum toxin type G and botulinum toxin type G, onabotulinumtoxinA, abobotulinumtoxinA, incobotulinumtoxinA, prabotulinumtoxinA, daxibotulinumtoxinA, rimabotulinumtoxinB, EB-001A, or EB-001T) were reconstituted with 10 mL of 0.9% sterile saline and the reconstituted Set aside the solution. Three percent (3%) hydrogen peroxide USP (6 mL) was added to 3 grams (dry weight) of the spongy spongy powder, and the resulting mixture was stirred to mix well. A portion of the reconstituted botulinum toxin composition is added to the spongy spongy mixture, and the resulting mixture is applied to the affected area of ​​the subject's skin, taking care to avoid mucous membranes (eg, eyes, mouth, and nostrils). The compositions ar...

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Abstract

The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to hyperhidrosis, comprising applying to the skin of the subject a first composition derivedfrom one or more sponges, and a second composition comprising one or more botulinum toxins. Also provided are compositions for use in the treatment of a skin condition in a subject, including but notlimited to hyperhidrosis, comprising a first composition and a second composition, wherein (a) the first composition comprises Spongilla; and (b) the second composition comprises one or more botulinum toxins. Also provided are kits, including kits for the treatment of a skin condition in a subject including but not limited to hyperhidrosis, comprising a first composition and a second composition,wherein the first composition comprises Spongilla, and the second composition comprises one or more botulinum toxins.

Description

[0001] cross reference [0002] This application claims U.S. Provisional Application No. 62 / 684,699, filed June 13, 2018, U.S. Provisional Application No. 62 / 788,628, filed January 4, 2019, and U.S. Provisional Application No. 62, filed April 25, 2019 / 838,801, all of these provisional applications are hereby incorporated by reference in their entirety. technical field [0003] The present disclosure relates to treating a skin disorder in a subject, including but not limited to hyperhidrosis, the treatment comprising applying to the skin of the subject a first composition derived from one or more sponges and A second composition comprising one or more botulinum toxins. In one aspect, the composition is derived from one or more sponges. In another aspect, the one or more sponges can be marine sponges or freshwater sponges. In another aspect, the one or more sponges are marine sponges. In another aspect, the sponge is a freshwater sponge. In another aspect, the composition ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K35/655A61K33/40A61K9/06A61K47/36A61K47/38A61K47/26A61P43/00
CPCA61K35/614A61K38/4893C12Y304/24069A61P17/00A61K2300/00A61K47/02A61P5/00A61P43/00A61K35/655
Inventor G·T·普罗尔C·J·纳尔多
Owner DERMATA THERAPEUTICS LLC